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Part 1: The Profession of Medicine
1 The Practice of MedicineThe Editors
2 Promoting Good HealthDonald
3 Decision-Making in Clinical Medicine
4 Screening and Prevention of Disease
5 Health Care Systems in Developed Countries
6 The Safety and Quality of Health
7 Racial and Ethnic Disparities in Health
8 Ethical Issues in Clinical Medicine
9 Palliative and End-of-Life
Part 2: Cardinal Manifestations and Presentation of Diseases
• Section 1: Pain 10 Pain: Pathophysiology and Management
11 Chest Discomfort
12 Abdominal Pain
13 Headache
14 Back and Neck Pain
• Section 2: Alterations in Body Temperature
15 Fever
16 Fever and Rash
17 Fever of Unknown Origin
• Section 3: Nervous System Dysfunction
18 Syncope
19 Dizziness and Vertigo
20 FatigueJeffrey
21 Neurologic Causes of Weakness and Paralysis
22 Numbness, Tingling, and Sensory Loss
23 Gait Disorders, Imbalance and Falls
24 Confusion and Delirium
25 DementiaWilliam
26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral Disorders
27 Sleep DisordersThomas
• Section 4: Disorders of Eyes, Ears, Nose, and Throat
28 Disorders of the Eye
29 Disorders of Smell and Taste
30 Disorders of Hearing
31 Sore Throat, Earache, and Upper Respiratory Symptoms
32 Oral Manifestations of Disease
• Section 5: Alterations in Circulatory and Respiratory Functions
33 Dyspnea
34 Cough Christopher
35 Hemoptysis
36 Hypoxia and Cyanosis
37 Edema
38 Approach to the Patient with a Heart
39 Palpitations
• Section 6: Alterations in Gastrointestinal Function
40 Dysphagia
41 Nausea, Vomiting, and Indigestion
42 Diarrhea and Constipation
43 Unintentional
44 Gastrointestinal Bleeding
45 Jaundice
46 Abdominal Swelling and Ascites
• Section 7: Alterations in Renal and Urinary Tract Function
47 Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain Syndrome
48 Azotemia and Urinary Abnormalities
49 Fluid and Electrolyte Disturbances
50 Hypercalcemia and Hypocalcemia
51 Acidosis and Alkalosis
• Section 8: Alterations in the Skin
52 Approach to the Patient with a Skin Disorder
53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
54 Skin Manifestations of Internal Disease
55 Immunologically Mediated Skin Diseases
56 Cutaneous Drug Reactions
57 Photosensitivity and Other Reactions to Light
• Section 9: Hematologic Alterations
58 Interpreting Peripheral Blood Smears
59 Anemia and Polycythemia
60 Disorders of Granulocytes and Monocytes
61 Bleeding and Thrombosis
62 Enlargement of Lymph Nodes and Spleen
Part 3: Pharmacology
63 Principles of Clinical Pharmacology
64 Pharmacogenomics
Part 4: Oncology and Hematology
• Section 1: Neoplastic Disorders
65 Approach to the Patient with Cancer
66 Prevention and Early Detection of Cancer
67 Cancer Genetics
68 Cancer Cell Biology
69 Principles of Cancer Treatment
70 Infections in Patients with Cancer
71 Oncologic Emergencies
72 Cancer of the Skin
73 Head and Neck Cancer
74 Neoplasms of the Lung
75 Breast Cancer
76 Upper Gastrointestinal Tract Cancers
77 Lower Gastrointestinal Cancers
78 Tumors of the Liver and Biliary Tree
79 Pancreatic Cancer
80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas
81 Renal Cell Carcinoma
82 Cancer of the Bladder and Urinary Tract
83 Benign and Malignant Diseases of the Prostate
84 Testicular Cancer
85 Gynecologic Malignancies
86 Primary and Metastatic Tumors of the Nervous System
87 Soft Tissue and Bone Sarcomas and Bone Metastases
88 Carcinoma of Unknown Primary
89 Paraneoplastic Syndromes: Endocrinologic/Hematologic
90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
91 Late Consequences of Cancer and Its Treatment
• Section 2: Hematopoietic Disorders
92 Hematopoietic Stem Cells
93 Iron Deficiency and Other Hypoproliferative Anemias
94 Disorders of Hemoglobin
95 Megaloblastic Anemias
96 Hemolytic Anemias
97 Anemia Due to Acute Blood Loss
98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
99 Polycythemia Vera and Other Myeloproliferative
100 Acute Myeloid Leukemia
101 Chronic Myeloid Leukemia
102 Acute Lymphoid Leukemia
103 Chronic Lymphocytic Leukemia
104 Non-Hodgkin’s Lymphoma
105 Hodgkin's Lymphoma
106 Less Common Hematologic Malignancies
107 Plasma Cell Disorders
108 Amyloidosis
109 Transfusion Biology and Therapy
110 Hematopoietic Cell Transplantation
• Section 3: Disorders of Hemostasis
111 Disorders of Platelets and Vessel Wall
112 Coagulation DisordersValder
113 Arterial and Venous Thrombosis
114 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Part 5: Infectious Diseases
• Section 1: Basic Considerations in Infectious Diseases
115 Approach to the Patient with an Infectious Disease
116 Molecular Mechanisms of Microbial Pathogenesis
117 Approach to the Acutely Ill Infected Febrile Patient
118 Immunization Principles and Vaccine Use
119 Health Recommendations for International Travel
120 Climate Change and Infectious Disease
• Section 2: Clinical Syndromes: Community-Acquired Infections
121 Pneumonia
122 Lung Abscess
123 Infective Endocarditis
124 Infections of the Skin, Muscles, and Soft Tissues
125 Infectious Arthritis
126 Osteomyelitis
127 Intraabdominal Infections and Abscesses
128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
129 Clostridium difficile Infection, Including Pseudomembranous Colitis
130 Urinary Tract Infections, Pyelonephritis, and Prostatitis
131 Sexually Transmitted Infections: Overview and Clinical Approach
132 Encephalitis
133 Acute Meningitis
134 Chronic and Recurrent Meningitis
135 Brain Abscess and Empyema
136 Infectious Complications of Bites
• Section 3: Clinical Syndromes: Health Care-Associated Infections
137 Infections Acquired in Health Care Facilities
138 Infections in Transplant Recipients
• Section 4: Therapy for Bacterial Diseases
139 Treatment and Prophylaxis of Bacterial Infections
140 Bacterial Resistance to Antimicrobial Agents
• Section 5: Diseases Caused by Gram-Positive Bacteria
141 Pneumococcal Infections
142 Staphylococcal Infections
143 Streptococcal Infections
144 Enterococcal Infections
145 Diphtheria and Other Corynebacterial Infections
146 Listeria monocytogenes Infections
147 Tetanus
148 Botulism
149 Gas Gangrene and Other Clostridial Infections
• Section 6: Diseases Caused by Gram-Negative Bacteria
150 Meningococcal Infections
151 Gonococcal Infections
152 Haemophilus and Moraxella Infections
153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
154 Legionella Infections
155 Pertussis and Other Bordetella Infections
156 Diseases Caused by Gram-Negative Enteric Bacilli
157 Acinetobacter Infections
158 Helicobacter pylori Infections
159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species
160 Salmonellosis
161 Shigellosis
162 Infections Due to Campylobacter and Related Organisms
163 Cholera and Other Vibrioses
164 Brucellosis
165 Tularemia
166 Plague and Other Yersinia Infections
167 Bartonella Infections, Including Cat-Scratch Disease
168 Donovanosis
• Section 7: Miscellaneous Bacterial Infections
169 Nocardiosis
170 Actinomycosis
171 Whipple’s Disease
172 Infections Due to Mixed Anaerobic Organisms
• Section 8: Mycobacterial Diseases
173 Tuberculosis
174 Leprosy
175 Nontuberculous Mycobacterial Infections
176 Antimycobacterial Agents
• Section 9: Spirochetal Diseases
177 Syphilis
178 Endemic Treponematoses
179 Leptospirosis
180 Relapsing Fever
181 Lyme Borreliosis
• Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
182 Rickettsial Diseases
183 Infections Due to Mycoplasmas
184 Chlamydial Infections
• Section 11: Viral Diseases: General Considerations
185 Medical Virology
186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs
• Section 12: Infections Due to DNA Viruses
187 Herpes Simplex Virus Infections
188 Varicella-Zoster Virus Infections
189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis
190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections
192 Parvovirus Infections
193 Human Papillomavirus Infections
• Section 13: Infections Due to DNA and RNA Respiratory Viruses
194 Common Viral Respiratory Infections
195 Influenza
• Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
196 The Human Retroviruses
197 Human Immunodeficiency Virus Disease: AIDS and Related Disorders
• Section 15: Infections Due to RNA Viruses
198 Viral Gastroenteritis
199 Enterovirus, Parechovirus, and Reovirus Infections
200 Measles (Rubeola)
201 Rubella (German Measles)
202 Mumps
203 Rabies and Other Rhabdovirus Infections
204 Arthropod-Borne and Rodent-Borne Virus Infections
205 Ebolavirus and Marburgvirus Infections
• Section 16: Fungal Infections
206 Diagnosis and Treatment of Fungal Infections
207 Histoplasmosis
208 Coccidioidomycosis
209 Blastomycosis
210 Cryptococcosis
211 Candidiasis
212 Aspergillosis
213 Mucormycosis
214 Superficial Mycoses and Less Common Systemic Mycoses
215 Pneumocystis Infections
• Section 17: Protozoal and Helminthic Infections: General Considerations
216 Introduction to Parasitic Infections
217 Agents Used to Treat Parasitic Infections
• Section 18: Protozoal Infections
218 Amebiasis and Infection with Free-Living Amebae
219 Malaria
220 Babesiosis
221 Leishmaniasis
222 Chagas Disease and African Trypanosomiasis
223 Toxoplasma Infections
224 Protozoal Intestinal Infections and Trichomoniasis
• Section 19: Helminthic Infections
225 Introduction to Helminthic Infections
226 Trichinellosis and Other Tissue Nematode Infections
227 Intestinal Nematode Infections
228 Filarial and Related Infections
229 Schistosomiasis and Other Trematode Infections
230 Cestode Infections
Part 6: Disorders of the Cardiovascular System
• Section 1: Introduction to Cardiovascular Disorders
231 Approach to the Patient with Possible Cardiovascular Disease
232 Basic Biology of the Cardiovascular System
233 Epidemiology of Cardiovascular Disease
• Section 2: Diagnosis of Cardiovascular Disorders
234 Physical Examination of the Cardiovascular System
235 Electrocardiography
236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging
237 Diagnostic Cardiac Catheterization and Coronary Angiography
• Section 3: Disorders of Rhythm
238 Principles of Electrophysiology
239 The Bradyarrhythmias: Disorders of the Sinoatrial Node
240 The Bradyarrhythmias: Disorders of the Atrioventricular Node
241 Approach to Supraventricular Tachyarrhythmias
242 Physiologic and Non-physiologic Sinus Tachycardia
243 Focal Atrial Tachycardia
244 Paroxysmal Supraventricular Tachycardias
245 Common Atrial Flutter, Macroreentrant and Multifocal Atrial Tachycardias
246 Atrial Fibrillation
247 Approach to Ventricular Arrhythmias
248 Premature Ventricular Beats, Non-sustained Ventricular Tachycardia, and Idioventricular Rhythm
249 Sustained Ventricular Tachycardia
250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation
251 Electrical Storm and Incessant VT
• Section 4: Disorders of the Heart
252 Heart Failure: Pathophysiology and Diagnosis
253 Heart Failure: Management
254 Cardiomyopathy and Myocarditis
255 Cardiac Transplantation and Prolonged Assisted Circulation
256 Aortic Valve Disease
257 Aortic Regurgitation
258 Mitral Stenosis
259 Mitral Regurgitation
260 Mitral Valve Prolapse
261 Tricuspid Valve Disease
262 Pulmonic Valve Disease
263 Multiple and Mixed Valvular Heart Disease
264 Congenital Heart Disease in the Adult
265 Pericardial Disease
266 Atrial Myxoma and Other Cardiac Tumors
• Section 5: Coronary and Peripheral Vascular Disease
267 Ischemic Heart Disease
268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)
269 ST-Segment Elevation Myocardial Infarction
270 Percutaneous Coronary Interventions and Other Interventional Procedures
271 Hypertensive Vascular Disease
272 Renovascular Disease
273 Deep Venous Thrombosis and Pulmonary Thromboembolism
274 Diseases of the Aorta
275 Arterial Diseases of the Extremities
276 Chronic Venous Disease and Lymphedema
277 Pulmonary Hypertension
Part 7: Disorders of the Respiratory System
• Section 1: Diagnosis of Respiratory Disorders
278 Approach to the Patient with Disease of the Respiratory System
279 Disturbances of Respiratory Function
280 Diagnostic Procedures in Respiratory Disease
• Section 2: Diseases of the Respiratory System
281 AsthmaPeter
282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia

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