NELSON TEXTBOOK OF PEDIATRICS, 2-VOLUME SET, 21ST EDITION

ChapTitle
Overview of Pediatrics
Child Health Disparities
Racism
Global Health
Quality and Value in Healthcare for Children
Safety in Healthcare for Children
Ethics in Pediatric Care
Pediatric Palliative Care
Domestic and International Adoption
Foster and Kinship Care
Medical Evaluation of the Foreign-Born Child
Cultural Issues in Pediatric Care
Maximizing Children’s Health: Screening, Anticipatory Guidance, and Counseling
Injury Control
Impact of Violence on Children
Bullying, Cyberbullying, and School Violence
Media Violence
Effects of War on Children
Child Trafficking
Abused and Neglected Children
Sexual Abuse
Medical Child Abuse (Factitious Disorder by Proxy, Munchausen Syndrome by Proxy)
Strategies for Health Behavior Change
Developmental and Behavioral Theories
Positive Parenting and Support
Assessment of Fetal Growth and Development
The Newborn
The First Year
Infant Crying and Colic
The Second Year
The Preschool Years
Middle Childhood
Adolescence
Assessment of Growth
Developmental and Behavioral Screening and Surveillance
Childcare
Loss, Separation, and Bereavement
Sleep Medicine
Psychosocial Assessment and Interviewing
Psychopharmacology
Psychotherapy and Psychiatric Hospitalization
Somatic Symptom and Related Disorders
Rumination and Pica
Rumination Disorder
Pica
Motor Disorders and Habits
Tic Disorders
Stereotypic Movement Disorders
Anxiety Disorders
Mood Disorders
Major and Other Depressive Disorders
Bipolar and Related Disorders
Suicide and Attempted Suicide
Eating Disorders
Disruptive, Impulse-Control, and Conduct Disorders
Tantrums and Breath-holding spells
Lying, Stealing and Truancy
Aggression
Self-injurious behavior
Childhood Psychoses
Schizophrenia Spectrum and Other Psychotic Disorders
Psychosis Associated with Epilepsy
Catatonia in Children and Adolescents
Acute Phobic Hallucinations of Childhood
Neurodevelopmental and Executive Function and Dysfunction
Attention-Deficit/Hyperactivity Disorder
Dyslexia
Math and Writing Disabilities
Math Disabilities
Writing Disabilities
Language Development and Communication Disorders
Child-Onset Fluency Disorder
Developmental Delay and Intellectual Disability
Intellectual Disability with Regression
Autism Spectrum Disorder
Nutritional Requirements
Feeding Healthy Infants, Children, and Adolescents
Nutrition, Food Security, and Health
Refeeding Syndrome
Failure to Thrive
Overweight and Obesity
Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic Dysregulation (ROHHAD)
Vitamin A Deficiencies and Excess
Vitamin B Complex Deficiencies and Excess
Thiamine (Vitamin B1)
Riboflavin (Vitamin B2)
Niacin (Vitamin B3)
Vitamin B6 (Pyridoxine)
Biotin
Folate
Vitamin B12 (Cobalamin)
Vitamin C (Ascorbic Acid)
Vitamin D Deficiency (Rickets) and Excess
Vitamin E Deficiency
Vitamin K Deficiency
Micronutrient Mineral Deficiencies
Electrolyte and Acid-Base Disorders
Composition of Body Fluids
Regulation of Osmolality and Volume
Sodium
Potassium
Magnesium
Phosphorus
Acid-Base Balance
Maintenance and Replacement Therapy
Deficit Therapy
Fluid and Electrolyte Treatment of Specific Disorders
Pediatric Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics
Principles of Drug Therapy
Anesthesia and Perioperative Care
Anesthetic Neurotoxicity
Sedation and Procedural Pain
Pediatric Pain Management
Poisoning
Complementary Therapies, and Integrative Medicine
Emergency Medical Services for Children
Interfacility Transport of the Seriously Ill or Injured Pediatric Patient
Outcomes and Risk-Adjustment
Principles Applicable to the Developing World
Triage of the Acutely Ill Child
Resuscitation
Acute Care of the Victim of Multiple Trauma
Spinal Cord Injuries in Children
Care of Abrasions and Minor Lacerations
Neurologic Emergencies and Stabilization
Brain Death
Syncope
POTS
Shock
Respiratory Distress and Failure
Mechanical Ventilation
Long-term Mechanical Ventilation
Altitude-associated Illness in Children (Acute Mountain Sickness)
Drowning and Submersion Injury
Burn injuries
Cold Injuries
Integration of Genetics into Pediatric Practice
Genetic Counseling
Management and Treatment of Genetic Disorders
The Genetic Approach in Pediatric Medicine
The Human Genome
Patterns of Genetic Transmission
Cytogenetics
Methods of Chromosome Analysis
Down Syndrome and Other Abnormalities of Chromosome Number
Abnormalities of Chromosome Structure
Sex Chromosome Aneuploidy
Fragile Chromosome Sites
Mosaicism
Chromosome Instability Syndromes
Uniparental Disomy and Imprinting
Genetics of Common Disorders
Major Genetic Approaches to the Study of Common Pediatric Disorders
Epigenome-Wide Association Studies and Disease
Genetic Approaches to Rare and Undiagnosed Diseases
An Approach to Inborn Errors of Metabolism
Defects in Metabolism of Amino Acids
Phenylalanine
Tyrosine
Methionine
Cysteine/Cystine
Tryptophan
Valine, Leucine, Isoleucine, and Related Organic Acidemias
Glycine
Serine
Proline
Glutamic Acid
Genetic Disorders of Neurotransmitters
Urea Cycle and Hyperammonemia (Arginine, Citrulline, Ornithine)
Histidine
Lysine
N-Acetylaspartic Acid (Canavan Disease)
Defects in Metabolism of Lipids
Disorders of Mitochondrial Fatty Acid ß-Oxidation
Disorders of Very Long Chain Fatty Acids
Disorders of Lipoprotein Metabolism and Transport
Lipidoses (Lysosomal Storage Disorders)
Mucolipidoses
Defects in Metabolism of Carbohydrates
Glycogen Storage Diseases
Defects in Galactose Metabolism
Defects in Fructose Metabolism
Defects in Intermediary Carbohydrate Metabolism Associated with Lactic Acidosis
Defects in Pentose Metabolism
Disorders of Glycoprotein Degradation
Congenital Disorders of Glycosolation
Approach to Mitochondrial Disorders
Mucopolysaccharidoses
Disorders of Purine and Pyrimidine Metabolism
Hutchinson-Gilford Progeria Syndrome
The Porphyrias
Hypoglycemia
Overview of Mortality and Morbidity
The Newborn Infant
History in Neonatal Pediatrics
Physical Examination of the Newborn Infant
Routine Newborn Care
Circumcision
Parent-Infant Bonding
High-Risk Pregnancies
The Fetus
Fetal Growth and Maturity
Fetal Distress
Maternal Disease and the Fetus
Maternal Medication and Toxin Exposure and the Fetus
Teratogens
Radiation
Intrauterine Diagnosis of Fetal Disease
Treatment and Prevention of Fetal Disease
Fetal Intervention and Surgery
The High-Risk Infant
Multiple Gestation Pregnancies
Extreme and Very Preterm Infants
Moderate and Late Pre-Term Infants
Term and Post-Term Infants
Follow-up of High-Risk Infants after Discharge
Infant Transport
Clinical Manifestations of Diseases in the Newborn Period
Hyperthermia
Neontal Cold Injury
Edema
Hypocalcemia (Tetany)
Hypermanganazemia
Nervous System Disorders
The Cranium
Traumatic, Epidural, Subdural, and Subarachnoid Hemorrhage
Intracranial-Intraventricular Hemorrhage and Periventricular Leukomalacia
Hypoxia-Ischemic Encephalopathy
Spine and Spinal Cord
Peripheral Nerve Injuries
Neonatal Resuscitation and Delivery Room Emergencies
Respiratory Tract Disorders
Transition to Pulmonary Respiration
Apnea
Respiratory Distress Syndrome (Hyaline Membrane Disease)
BPD
PDA
Transient Tachypnea of the Newborn
Aspiration of Foreign Material (Fetal Aspiration Syndrome, Aspiration Pneumonia)
Meconium Aspiration
Persistent Pulmonary Hypertension of the Newborn (Persistent Fetal Circulation)
Diaphragmatic Hernia
Foramen of Morgagni Hernia
Paraesophageal Hernia
Eventration
Extrapulmonary Air Leaks (Pneumothorax, Pneumomediastinum, Pulmonary Interstitial Emphysema, Pneumopericardium)
Pulmonary Hemorrhage
Digestive System Disorders
Meconium Ileus, Peritonitis, and Intestinal Obstruction
Necrotizing Enterocolitis
Jaundice and Hyperbilirubinemia in the Newborn
Kernicterus
Blood Disorders
Anemia in the Newborn Infant
Hemolytic Disease of the Newborn (Erythroblastosis Fetalis)
Plethora in the Newborn Infant (Polycythemia)
Hemorrhage in the Newborn Infant
The Umbilicus
Abstinence Syndromes
Neonatal Abstinence (Withdrawal)
Maternal Selective Serotonin Reuptake Inhibitors and Neonatal Behavioral Syndromes
Fetal Alcohol Exposure
The Endocrine System
Infants of Diabetic Mothers
Dysmorphology
Epidemiology of Infections
Healthcare-Associated Infections (HAI)
Congenital Infections
Adolescent Physical and Social Development
Gender and Sexual Identity
Gay, Lesbian & Bisexual Adolescents
Transgender Care
The Epidemiology of Adolescent Health Problems
Delivery of Health Care to Adolescents
Legal Issues
Screening Procedures
Transitioning to Adult Care
Violent Behavior
Substance Abuse
Alcohol
Tobacco and Electronic Nicotine Delivery Systems
Marijuana
Inhalants
Hallucinogens
Cocaine
Amphetamines
Stimulant Abuse and Diversion
Opiates
Bath salts and other drugs of abuse
The Breast
Menstrual Problems
Amenorrhea
Abnormal Uterine Bleeding
Dysmenorrhea
Premenstrual Syndrome and Premenstrual Dysphoric Disorder
Contraception
Long-Acting Reversible Contraception (LARC)
Other Progestin-only Methods
Combined Hormonal Contraceptives
Emergency Contraception (EC)
Dual Protection
Other Barrier Methods
Other Methods
Adolescent Pregnancy
Adolescent Sexual Assault
Sexually Transmitted Infections
Chronic Overlapping Pain Syndromes
Chronic Fatigue Syndrome/Systemic Exertion Intolerance Disease
Evaluation of Suspected Immunodeficiency
Lymphocyte Development and Function
Primary Defects of Antibody Production
Treatment of B-Cell Defects
Primary Defects of Cellular Immunity
Immune Deficiencies Affecting Multiple Cell Types
Severe Combined Immunodeficiency
Combined Immunodeficiency
Defects of Innate Immunity
Treatment of Cellular or Combined Immunodeficiency
Immune Dysregulation with Autoimmunity or Lymphoproliferation
Neutrophils
Monocytes, Macrophages, and Dendritic Cells
Eosinophils
Disorders of Phagocyte Function
Leukopenia
Leukocytosis
The Complement System
Disorders of the Complement System
Evaluation of the Complement System
Genetic Deficiencies of Complement Components
Deficiencies of Plasma, Membrane, or Serosal Complement Control Proteins
Secondary Disorders of Complement
Treatment of Complement Disorders
Principles and Clinical Indications of Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation from Alternative Sources and Donors
Graft-Versus-Host Disease, Rejection, and Veno-occlusive Disease
Infectious Complications of Hematopoietic Stem Cell Transplantation
Late Effects of Hematopoietic Stem Cell Transplantation
Allergy and the Immunologic Basis of Atopic Disease
Diagnosis of Allergic Disease
Allergic Rhinitis
Childhood Asthma
Atopic Dermatitis (Atopic Eczema)
Insect Allergy
Ocular Allergies
Urticaria (Hives) and Angioedema
Anaphylaxis
Serum Sickness
Food Allergy and Adverse Reactions to Foods
Adverse Reactions to Drugs
Evaluation of Suspected Rheumatic Disease
Treatment of Rheumatic Diseases
Juvenile Idiopathic Arthritis
Ankylosing Spondylitis and Other Spondyloarthritides
Reactive and Post-Infectious Arthritis
Systemic Lupus Erythematosus
Neonatal Lupus
Juvenile Dermatomyositis
Scleroderma and Raynaud Phenomenon
Behçet Disease
Sjögren Syndrome
The Hereditary Periodic Fever Syndromes and Other Systemic Autoinflammatory Diseases
Amyloidosis
Sarcoidosis
Kawasaki Disease
Vasculitis Syndromes
Henoch-Schönlein Purpura
Takayasu Arteritis
Polyarteritis Nodosa and Cutaneous Polyarteritis Nodosa
ANCA-associated vasculitis
Other Vasculitic Syndromes
Musculoskeletal Pain Syndromes
Growing Pains
Small Fiber Polyneuropathy
Fibromyalgia
Complex Regional Pain Syndrome
Erythromelalgia
Miscellaneous Conditions Associated With Arthritis
Diagnostic Microbiology
The Microbiome and Pediatric Health
Immunization Practices
International Immunization Practices
Infection Prevention and Control
Childcare and Communicable Diseases
Health Advice for Children Traveling Internationally
Fever
Fever Without a Focus in the Neonate (0-2 mos)
Fever in the Older Child
Fever of Unknown Origin
Infections in Immunocompromised Persons
Infections Occurring with Primary Immunodeficiencies
Infections Occuring with Acquired Immunodeficiencies
Prevention of Infection in Immunocompromised Persons
Infection Associated with Medical Devices
Principles of Antibacterial Therapy
Staphylococcus
Staphylococcus aureus
Toxic Shock Syndrome
Coagulase-Negative Staphylococci
Streptococcus pneumoniae (Pneumococcus)
Group A Streptococcus
Rheumatic Fever
Group B Streptococcus
Non-Group A or B Streptococci
Enterococcus
Diphtheria (Corynebacterium diphtheriae)
Listeria monocytogenes
Actinomyces
Nocardia
Neisseria meningitidis (Meningococcus)
Neisseria gonorrhoeae (Gonococcus)
Kingella kingae
Haemophilus influenzae
Chancroid (Haemophilus ducreyi)
Moraxella catarrhalis
Pertussis (Bordetella pertussis and Bordetella parapertussis)
Salmonella
Nontyphoidal Salmonellosis
Enteric Fever (Typhoid Fever)
Shigella
Escherichia coli
Cholera
Campylobacter
Yersinia
Yersinia enterocolitica
Yersinia pseudotuberculosis
Plague (Yersinia pestis)
Aeromonas and Plesiomonas
Aeromonas
Plesiomonas shigelloides
Pseudomonas, Burkholderia, and Stenotrophomonas
Pseudomonas
Burkholderia Cepacia Complex
Stenotrophomonas
Tularemia (Francisella tularensis)
Brucella
Legionella
Bartonella
Cat Scratch Disease (Bartonella henselae)
Bartonellosis (Bartonella bacilliformis)
Trench Fever (Bartonella quintana)
Bacillary Angiomatosis and Bacillary Peliosis Hepatis (Bartonella henselae and Bartonella quintana)
Botulism (Clostridium botulinum)
Tetanus (Clostridium tetani)
Clostridium difficile Infection
Other Anaerobic Infections
Principles of Antimycobacterial Therapy
Tuberculosis (Mycobacterium tuberculosis)
Hansen Disease (Mycobacterium leprae)
Nontuberculous Mycobacteria
Syphilis (Treponema pallidum)
Nonvenereal Treponemal Infections
Yaws (Treponema pertenue)
Bejel (Endemic Syphilis: Treponema pallidum endemicum)
Pinta (Treponema carateum)
Leptospira
Relapsing Fever (Borrelia)
Lyme Disease (Borrelia burgdorferi)
Mycoplasma pneumoniae
Genital Mycoplasmas (Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum)
Chlamydia (Chlamydophila) pneumoniae
Chlamydia trachomatis
Trachoma
Genital Tract Infections
Conjunctivitis and Pneumonia in Newborns
Lymphogranuloma Venereum
Psittacosis (Chlamydia psittaci)
Spotted Fever Group Rickettsioses
Rocky Mountain Spotted Fever (Rickettsia rickettsii)
Mediterranean Spotted Fever or Boutonneuse Fever (Rickettsia conorii)
Rickettsialpox (Rickettsia akari)
Scrub Typhus (Orientia tsutsugamushi)
Typhus Group Rickettsioses
Murine (endemic or flea-borne) Typhus (Rickettsia typhi)
Epidemic (louse-borne) Typhus (Rickettsia prowazekii)
Ehrlichioses and Anaplasmosis
Q Fever (Coxiella burnetii)
Principles of Antifungal Therapy
Candida
Neonatal Infections
Infections in Immunocompetent Children and Adolescents
Infections in Immunocompromised Children and Adolescents
Cryptococcus neoformans
Malassezia
Aspergillus
Allergic Disease (Hypersensitivity Syndromes)
Saprophytic (Noninvasive) Syndromes
Invasive Disease
Histoplasmosis (Histoplasma capsulatum)
Blastomycosis (Blastomyces dermatitidis)
Coccidioidomycosis (Coccidioides Species)
Paracoccidioides brasiliensis
Sporotrichosis (Sporothrix schenckii)
Zygomycosis (Mucormycosis)
Pneumocystis Jirovecii
Principles of Antiviral Therapy
Measles
Rubella
Mumps
Polioviruses
Nonpolio Enteroviruses
Parvoviruses
Herpes Simplex Virus
Varicella-Zoster Virus Infections
Epstein-Barr Virus
Cytomegalovirus
Roseola (Human Herpesviruses 6 and 7)
Human Herpesvirus 8
Influenza Viruses
Parainfluenza Viruses
Respiratory Syncytial Virus
Human Metapneumovirus
Adenoviruses
Rhinoviruses
Coronaviruses
Rotaviruses, Calicivirus, and Astrovirus
Human Papillomaviruses
Arboviral Infections
Eastern Equine Encephalitis
Western Equine Encephalitis
St. Louis Encephalitis
West Nile Encephalitis
Powassan Encephalitis
LaCrosse and California Encephalitis
Colorado Tick Fever
Chikungunya Fever
Venezuelan Equine Encephalitis
Japanese Encephalitis
Tick-Borne Encephalitis
Zika Virus
Dengue Fever and Dengue Hemorrhagic Fever
Yellow Fever
Other Viral Hemorrhagic Fevers
Lymphocytic Choriomeningitis Virus (LCMV)
Hantavirus Pulmonary Syndrome
Rabies
Polyomaviruses
Acquired Immunodeficiency Syndrome (Human Immunodeficiency Virus)
Human T-Lymphotropic Viruses (1 and 2)
Transmissible Spongiform Encephalopathies
Principles of Antiparasitic Therapy
Primary Amebic Meningoencephalitis
Amebiasis
Giardiasis and Balantidiasis
Giardia lamblia
Balantidiasis
Cryptosporidium, Isospora, Cyclospora, and Microsporidia
Trichomoniasis (Trichomonas vaginalis)
Leishmaniasis (Leishmania)
African Trypanosomiasis (Sleeping Sickness; Trypanosoma brucei complex)
American Trypanosomiasis (Chagas Disease; Trypanosoma cruzi)
Malaria (Plasmodium)
Babesiosis (Babesia)
Toxoplasmosis (Toxoplasma gondii)
Ascariasis (Ascaris lumbricoides)
Hookworms (Necator americanus and Ancylostoma spp.)
Cutaneous Larva Migrans
Trichuriasis (Trichuris trichuria)
Enterobiasis (Enterobius vermicularis)
Strongyloidiasis (Strongyloides stercoralis)
Lymphatic Filariasis (Brugia malayi, Brugia timori, and Wuchereria bancrofti)
Other Tissue Nematodes
Toxocariasis (Visceral and Ocular Larva Migrans)
Trichinellosis (Trichinella spiralis)
Schistosomiasis (Schistosoma)
Flukes (Liver, Lung, and Intestinal)
Adult Tapeworm Infections
Cysticercosis
Echinococcosis (Echinococcus granulosus and Echinococcus multilocularis)
Normal Digestive Tract Phenomena
Major Symptoms and Signs of Digestive Tract Disorders
Development and Developmental Anomalies of the Teeth
Disorders of the Oral Cavity Associated with Other Conditions
Malocclusion
Cleft Lip and Palate
Syndromes with Oral Manifestations
Dental Caries
Periodontal Diseases
Dental Trauma
Common Lesions of the Oral Soft Tissues
Diseases of the Salivary Glands and Jaws
Diagnostic Radiology in Dental Assessment
Embryology, Anatomy, and Function of the Esophagus
Common Clinical Manifestations and Diagnostic Aids
Congenital Anomalies
Esophageal Atresia and Tracheoesophageal Fistula
Laryngotracheoesophageal Clefts
Obstructing and Motility Disorders of the Esophagus
Dysmotility
Hiatal Hernia
Gastroesophageal Reflux Disease
Complications of Gastroesophageal Reflux Disease
Eosinophilic Esophagitis and Non-GERD Esophagitis
Esophageal Perforation
Esophageal Varices
Ingestions
Foreign Bodies in the Esophagus
Caustic Ingestions
Normal Development, Structure, and Function
Pyloric Stenosis and Other Congenital Anomalies of the Stomach
Hypertrophic Pyloric Stenosis
Congenital Gastric Outlet Obstruction
Gastric Duplication
Gastric Volvulus
Hypertrophic Gastropathy
Intestinal Atresia, Stenosis, and Malrotation
Duodenal Obstruction
Jejunal and Ileal Atresia and Obstruction
Malrotation
Intestinal Duplications, Meckel Diverticulum, and Other Remnants of the Omphalomesenteric Duct
Intestinal Duplication
Meckel Diverticulum and Other Remnants of the Omphalomesenteric Duct
Motility Disorders and Hirschsprung Disease
Chronic Intestinal Pseudo-Obstruction
Mitochondrial Neurogastrointestinal Encephalomyopathy
Encopresis and Functional Constipation
Congenital Aganglionic Megacolon (Hirschsprung Disease)
Intestinal Neuronal Dysplasia
Superior Mesenteric Artery Syndrome (Wilkie Syndrome, Cast Syndrome, Arteriomesenteric Duodenal Compression Syndrome)
Ileus, Adhesions, Intussusception, and Closed-Loop Obstructions
Ileus
Adhesions
Intussusception
Closed-Loop Obstructions
Foreign Bodies and Bezoars
Foreign Bodies in the Stomach and Intestine
Bezoars
Peptic Ulcer Disease in Children
Zollinger-Ellison Syndrome
Inflammatory Bowel Disease
Chronic Ulcerative Colitis
Crohn Disease (Regional Enteritis, Regional lleitis, Granulomatous Colitis)
Very Early Onset IBD
Eosinophilic Gastroenteritis
Disorders of Malabsorption
Evaluation of Children with Suspected Intestinal Malabsorption
Celiac Disease (Gluten-Sensitive Enteropathy)
Other Malabsorptive Syndromes
Intestinal Infections and Infestations Associated with Malabsorption
Immunodeficiency Disorders
Immunoproliferative Small Intestinal Disease
Short Bowel Syndrome
Chronic Malnutrition
Enzyme Deficiencies
Liver and Biliary Disorders Causing Malabsorption
Rare Inborn Defects Causing Malabsorption
Malabsorption in Eosinophilic Gastroenteritis
Malabsorption in Inflammatory Bowel Disease
Intestinal Transplantation in Children with Intestinal Failure
Acute Gastroenteritis in Children
Traveler's Diarrhea
Chronic Diarrhea
Diarrhea from Neuroendocrine Tumors
Functional Abdominal pain (Nonorganic Chronic Abdominal pain)
Cyclic vomiting and abdominal migraine
Acute Appendicitis
Surgical Conditions of the Anus and Rectum
Anorectal Malformations
Anal Fissure
Perianal Abscess and Fistula
Hemorrhoids
Rectal Mucosal Prolapse
Pilonidal Sinus and Abscess
Tumors of the Digestive Tract
Inguinal Hernias
Embryology, Anatomy, and Physiology
Anatomic Abnormalities
Physiology
Pancreatic Function Tests
Disorders of the Exocrine Pancreas
Treatment of Pancreatic Insufficiency
Pancreatitis
Acute Pancreatitis
Chronic Pancreatitis
Pseudocyst of the Pancreas
Pancreatic Tumors
Morphogenesis of the Liver and Biliary System
Manifestations of Liver Disease
Evaluation of Patients with Possible Liver Dysfunction
Cholestasis
Neonatal Cholestasis
Cholestasis in the Older Child
Metabolic Diseases of the Liver
Inherited Deficient Conjugation of Bilirubin (Familial Nonhemolytic Unconjugated Hyperbilirubinemia)
Wilson Disease
Indian Childhood Cirrhosis
Neonatal Iron Storage Disease
Miscellaneous Metabolic Diseases of the Liver
Viral Hepatitis
Liver Abscess
Liver Disease Associated with Systemic Disorders
Nonalcoholic Fatty Liver Disease
Mitochondrial Hepatopathies
Autoimmune Hepatitis
Drug- and Toxin-Induced Liver Injury
Fulminant Hepatic Failure
Cystic Diseases of the Biliary Tract and Liver
Diseases of the Gallbladder
Portal Hypertension and Varices
Liver Transplantation
Malformations
Ascites
Chylous Ascites
Peritonitis
Acute Primary Peritonitis
Acute Secondary Peritonitis
Acute Secondary Localized Peritonitis (Peritoneal Abscess)
Epigastric Hernia
Incisional Hernia
Diagnostic Approach to Respiratory Disease
Chronic or Recurrent Respiratory Symptoms
Sudden Infant Death Syndrome
Sudden Unexpected Postnatal Collapse (SUPC)
BRUE / ALTE
Congenital Disorders of the Nose
Acquired Disorders of the Nose
Foreign Body
Epistaxis
Nasal Polyps
The Common Cold
Sinusitis
Acute Pharyngitis
Retropharyngeal Abscess, Lateral Pharyngeal (Parapharyngeal) Abscess, and Peritonsillar Cellulitis/Abscess
Tonsils and Adenoids
Acute Inflammatory Upper Airway Obstruction (Croup, Epiglottitis, Laryngitis, and Bacterial Tracheitis)
Infectious Upper Airway Obstruction
Bacterial Tracheitis
Congenital Anomalies of the Larynx, Trachea, and Bronchi
Laryngomalacia
Congenital Subglottic Stenosis
Vocal Cord Paralysis
Congenital Laryngeal Webs and Atresia
Congenital Subglottic Hemangioma
Laryngoceles and Saccular Cysts
Posterior Laryngeal Cleft and Laryngotracheoesophageal Cleft
Vascular and Cardiac Anomalies
Tracheal Stenoses, Webs, and Atresia
Foregut Cysts
Tracheomalacia and Bronchomalacia
Foreign Bodies of the Airway
Laryngeal Foreign Bodies
Tracheal Foreign Bodies
Bronchial Foreign Bodies
Laryngotracheal Stenosis and Subglottic Stenosis
Congenital Subglottic Stenosis
Acquired Laryngotracheal Stenosis
Bronchomalacia and Tracheomalacia
Neoplasms of the Larynx, Trachea, and Bronchi
Vocal Nodules
Recurrent Respiratory Papillomatosis
Congenital Subglottic Hemangioma
Vascular Anomalies
Other Laryngeal Neoplasms
Tracheal Neoplasms
Bronchial Tumors
Wheezing, Bronchiolitis, and Bronchitis
Wheezing in Infants: Bronchiolitis
Bronchitis
Plastic Bronchitis
Emphysema and Overinflation
a1-Antitrypsin Deficiency and Emphysema
Other Distal Airway Diseases
Bronciolitis Obliterans
Follicular Bronchitis
Pulmonary Alveolar Microlithiasis
Congenital Disorders of the Lung
Pulmonary Agenesis and Aplasia
Pulmonary Hypoplasia
Congenital Cystic Malformation
Pulmonary Sequestration
Bronchogenic Cysts
Congenital Pulmonary Lymphangiectasia
Lung Hernia
Other Congenital Malformations of the Lung
Pulmonary Edema
Aspiration Syndromes
Chronic Recurrent Aspiration
Immune and Inflammatory Lung Disease
Hypersensitivity Pneumonia
Occupational and Environmental Lung Disease
Granulomatous Lung Disease
Eosinophilic Lung Disease
Interstitial Lung Diseases
Neuroendocrine cell hyperplasia of infancy
Idiopathic Pulmonary Fibrosis
Community-Acquired Pneumonia
Pleural Effusion and Empyema
Dry or Plastic Pleural Effusion
Serofibrinous or Serosanguineous Pleural Effusion
Empyema
Bronchiectasis
Pulmonary Abscess
Cystic Fibrosis
Primary Ciliary Dyskinesia (Immotile Cilia Syndrome, Kartagener Syndrome)
Diffuse Lung Diseases in Childhood
Inherited Disorders of Surfactant Metabolism
Pulmonary Alveolar Proteinosis
Pulmonary Hemosiderosis
Pulmonary Embolism, Infarction, and Hemorrhage
Pulmonary Embolus and Infarction
Pulmonary Hemorrhage and Hemoptysis
Atelectasis
Pulmonary Tumors
Pneumothorax
Pneumomediastinum
Hydrothorax
Hemothorax
Chylothorax
Bronchopulmonary Dysplasia
Skeletal Diseases Influencing Pulmonary Function
Pectus Excavatum (Funnel Chest)
Pectus Carinatum and Sternal Clefts
Asphyxiating Thoracic Dystrophy (Thoracic-Pelvic-Phalangeal Dystrophy)
Achondroplasia
Kyphoscoliosis: Adolescent Idiopathic Scoliosis and Congential Scoliosis
Congenital Rib Anomalies
Chronic Respiratory Insufficiency
Neuromuscular Diseases
Congenital Central Hypoventilation Syndrome
Other Conditions
Long-Term Mechanical Ventilation
Cardiac Development
Early Cardiac Morphogenesis
Cardiac Looping
Cardiac Septation
Aortic Arch Development
Cardiac Differentiation
Developmental Changes in Cardiac Function
The Fetal to Neonatal Circulatory Transition
The Fetal Circulation
The Transitional Circulation
The Neonatal Circulation
History and Physical Examination
Laboratory Evaluation
Radiologic Assessment
Electrocardiography
Hematologic Data
Echocardiography
Exercise Testing
MRI, MRA, CT, and Radionuclide Studies
Diagnostic and Interventional Cardiac Catheterization
Epidemiology and Genetic Basis of Congenital Heart Disease
Evaluation and Screening of the Infant or Child with Congenital Heart Disease
Acyanotic Congenital Heart Disease: The Left-to-Right Shunt Lesions
Atrial Septal Defect
Ostium Secundum Defect
Sinus Venosus Atrial Septal Defect
Partial Anomalous Pulmonary Venous Return
Atrioventricular Septal Defects (Ostium Primum and Atrioventricular Canal or Endocardial Cushion Defects)
Ventricular Septal Defect
Supracristal Ventricular Septal Defect with Aortic Insufficiency
Patent Ductus Arteriosus
Aortopulmonary Window Defect
Coronary Artery Fistula
Ruptured Sinus of Valsalva Aneurysm
Acyanotic Congenital Heart Disease: The Obstructive Lesions
Pulmonary Valve Stenosis with Intact Ventricular Septum
Infundibular Pulmonary Stenosis and Double-Chamber Right Ventricle
Pulmonary Stenosis in Combination with an Intracardiac Shunt
Peripheral Pulmonary Stenosis
Aortic Stenosis
Coarctation of the Aorta
Coarctation with Ventricular Septal Defect
Coarctation with Other Cardiac Anomalies and Interrupted Aortic Arch
Congenital Mitral Stenosis
Pulmonary Venous Hypertension
Acyanotic Congenital Heart Disease: Regurgitant Lesions
Pulmonary Valvular Insufficiency and Congenital Absence of the Pulmonary Valve
Congenital Mitral Insufficiency
Mitral Valve Prolapse
Tricuspid Regurgitation
Cyanotic Congenital Heart Disease: Evaluation of the Critically Ill Neonate with Cyanosis and Respiratory Distress
Cyanotic Congenital Heart Lesions: Lesions Associated with Decreased Pulmonary Blood Flow
Tetralogy of Fallot
Tetraology of Fallot with Pulmonary Atresia
Pulmonary Atresia with Intact Ventricular Septum
Tricuspid Atresia
Double-Outlet Right Ventricle
Transposition of the Great Arteries with Ventricular Septal Defect and Pulmonary Stenosis
Ebstein Anomaly of the Tricuspid Valve
Cyanotic Congenital Heart Disease: Lesions Associated with Increased Pulmonary Blood Flow
D-Transposition of the Great Arteries
D-Transposition of the Great Arteries with Intact Ventricular Septum
Transposition of the Great Arteries with Ventricular Septal Defect
L-Transposition of the Great Arteries (Corrected Transposition)
Double-Outlet Right Ventricle Without Pulmonary Stenosis
Double-Outlet Right Ventricle with Malposition of the Great Arteries (Taussig-Bing Anomaly)
Total Anomalous Pulmonary Venous Return
Truncus Arteriosus
Single Ventricle (Double-Inlet Ventricle, Univentricular Heart)
Hypoplastic Left Heart Syndrome
Abnormal Positions of the Heart and the Heterotaxy Syndromes (Asplenia, Polysplenia)
Other Congenital Heart and Vascular Malformations
Anomalies of the Aortic Arch
Anomalous Origin of the Coronary Arteries
Pulmonary Arteriovenous Fistula
Ectopia Cordis
Diverticulum of the Left Ventricle
Pulmonary Hypertension
Primary Pulmonary Hypertension
Pulmonary Vascular Disease (Eisenmenger Syndrome)
General Principles of Treatment of Congenital Heart Disease
Congenital Heart Disease in Adults
Disturbances of Rate and Rhythm of the Heart
Principles of Antiarrhythmic Therapy
Sinus Arrhythmias and Extrasystoles
Supraventricular Tachycardia
Ventricular Tachyarrhythmias
Long Q-T Syndromes
Sinus Node Dysfunction
AV Blcok
Sudden Death
Infective Endocarditis
Rheumatic Heart Disease
Diseases of the Myocardium
Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Restrictive Cardiomyopathy
Left Ventricular Noncompaction, Arrhythmogenic Right Ventricular Cardiomyopathy, and Endocardial Fibroelastosis
Myocarditis
Diseases of the Pericardium
Acute Pericarditis
Constrictive Pericarditis
Tumors of the Heart
Heart Failure
Cardiogenic Shock
Pediatric Heart and Heart-Lung Transplantation
Pediatric Heart Transplantation
Heart-Lung and Lung Transplantation
Diseases of the Blood Vessels (Aneurysms and Fistulas)
Kawasaki Disease
Arteriovenous Fistulas
Infantile Calcifications (GACI, IIAC, and ACDC)
Systemic Hypertension
Development of the Hematopoietic System
The Anemias
Congenital Hypoplastic Anemia (Diamond-Blackfan Anemia )
Pearson's Syndrome
Acquired Pure Red Blood Cell Anemia
Anemia of Chronic Disease and Renal Disease
Anemia of Chronic Disease (ACD)
Anemia of Renal Disease
Congenital Dyserythropoietic Anemias
Physiologic Anemia of Infancy
Megaloblastic Anemias
Folic Acid Deficiency
Vitamin B12 (Cobalamin) Deficiency
Other Rare Megaloblastic Anemias
Iron-Deficiency Anemia
Iron-Refractory Iron Deficiency Anemia
Other Microcytic Anemias
Definitions and Classification of Hemolytic Anemias
Hereditary Spherocytosis
Hereditary Elliptocytosis
Hereditary Stomatocytosis
Paroxysmal Nocturnal Hemoglobinuria and Acanthocytosis
Hemoglobinopathies
Sickle Cell Disease
Sickle Cell Trait (Hemoglobin AS)
Other Hemoglobinopathies
Unstable Hemoglobin Disorders
Abnormal Hemoglobins with Increased Oxygen Affinity
Abnormal Hemoglobins Causing Cyanosis
Hereditary Methemoglobinemia
Hereditary Methemoglobinemia with Deficiency of NADH Cytochrome B5 Reductase
Syndromes of Hereditary Persistence of Fetal Hemoglobin (HPFH)
Thalassemia Syndromes
Enzymatic Defects
Pyruvate Kinase Deficiency
Other Glycolytic Enzyme Deficiencies
Glucose-6-Phosphate Dehydrogenase Deficiency and Related Deficiencies
Hemolytic Anemias Resulting from Extracellular Factors- Immune Hemolytic Anemias
Hemolytic Anemias Secondary to Other Extracellular Factors
Polycythemia
Non-Clonal Polycythemia
The Inherited Pancytopenias
The Acquired Pancytopenias
Red Blood Cell Transfusions and Erythropoietin Therapy
Platelet Transfusions
Neutrophil (Granulocyte) Transfusions
Plasma Transfusions
Risks of Blood Transfusions
Hemostasis
The Clinical and Laboratory Evaluation of Hemostasis
Hereditary Clotting Factor Deficiencies (Bleeding Disorders)
Factor VIII or Factor IX Deficiency (Hemophilia A or B)
Factor XI Deficiency (Hemophilia C)
Deficiencies of the Contact Factors (Nonbleeding Disorders)
Factor VII Deficiency
Factor X Deficiency
Prothrombin (Factor II) Deficiency
Factor V Deficiency

Welcome to the 21st Edition of Nelson Textbook of Pediatrics - the reference of choice among pediatricians, pediatric residents, and others involved in the care of young patients. This fully revised edition continues to provide the breadth and depth of knowledge you expect from Nelson, while also keeping you up to date with new advances in the science and art of pediatric practice. Authoritative and reader-friendly, it delivers the information you need in a concise, easy-to-use format for everyday reference and study. From rapidly changing diagnostic and treatment protocols to new technologies to the wide range of biologic, psychologic, and social problems faced by children today, this comprehensive 2-volume reference keeps you on the cutting edge of the very best in pediatric care.

Authors
• Robert M. Kliegman, MD, Professor and Chair Emeritus, Department of Pediatric, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, Wisconsin.
• Joseph St. Geme, MD, Chair, Department of Pediatrics, Professor of Pediatrics and Microbiology, Perelman School of Medicine at the University of Pennsylvania; Physician-in-Chief, Leonard and Madlyn Abramson Endowed Chair in Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania