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• Section 1: Anatomy of the Pancreas
1. Development of the pancreas and related structures
2. Anatomy and the fine structure of the pancreas
3. Congenital and inherited anomalies
• Section 2: Physiology and Pathophysiology of Pancreatic Functions
4. Physiology of acinus cell secretion
5. Physiology of duct cell secretion
6. Pathophysiology of experimental pancreatitis
7. Physiology and pathophysiology of function of sphincter of Oddi
8. Neurohormonal and hormonal control of pancreatic secretion
9. Regulation of pancreatic protein synthesis and growth
10. Fibrogenesis of the pancreas: The role of stellate cells
11. Fibrogenesis of the pancreas: The role of macrophages
12. Insulo-acinar relationship
• Section 3: Acute Pancreatitis
13. Epidemiology and etiology of alcohol-induced pancreatitis
14. Etiology and epidemiology of biliary acute pancreatitis
15. Genetic factors in acute pancreatitis
16. The role of the intestine and the mesenteric lymph in the development of SIRS and MODS in severe acute pancreatitis
17. Neuroinflammation in acute pancreatitis
18. Molecular biochemical and metabolic abnormalities of acute pancreatitis
19. Histopathology of acute pancreatitis
20. Clinical classification systems of acute pancreatitis
21. Clinical assessment and biochemical markers to objectify severity and prognosis
22. Acute pancreatitis associated with congenital anomalies
23. Acute pancreatitis in children
24. Acute pancreatitis associated with metabolic, infections and drug-related diseases
25. Radiologic diagnosis and staging of severe acute pancreatitis
- Clinical course and medical treatment of acute pancreatitis (26–29)
26. Conservative therapy of acute pancreatitis: Volume substitution and enteral and parenteral nutrition
27. ICU treatment of severe acute pancreatitis
28. The use of antibiotics in severe acute pancreatitis: Indications and limitations
29. Indication for interventional and surgical treatment of necrotizing pancreatitis
30. Management of infected pancreatic necroses: An endoscopic approach
31. Minimal-invasive debridement and lavage of necrotizing pancreatitis
32. Open surgical debridement of necrotizing pancreatitis
33. Endoscopic treatment of biliary acute pancreatitis
34. Strategies of management of pseudo cysts and walled-off necroses after acute pancreatitis: Interventional endoscopic approach
35. Surgical treatment of pseudo cysts and walled-off necroses after acute pancreatitis
36. Management of fluid collection in acute pancreatitis
37. Management of pancreatic fistula in acute pancreatitis
38. Long-term outcome after acute pancreatitis
• Section 4: Chronic Pancreatitis
39. Molecular understanding of chronic pancreatitis
40. Epidemiology and pathophysiology of alcoholic chronic pancreatitis
41. Pain mechanisms in chronic pancreatitis
42. Natural history of recurrent acute and chronic pancreatitis
43. Chronic pancreatitis with inflammatory mass in the pancreatic head
44. Early stage chronic pancreatitis
45. Hereditary chronic pancreatitis: Molecular pattern, clinical consequences, management principles
46. Epidemiology and pathophysiology of tropical chronic pancreatitis
47. Cystic fibrosis (CFTR)-associated pancreatic disease
48. Clinical and laboratory diagnosis of chronic pancreatitis
49. Evidence of contrast enhanced CT and MRI/MRCP
50. Chronic pancreatitis: Risk factors in cancer
51. Pain management of chronic pancreatitis
52. Medical treatment of chronic pancreatitis: Pancreatic digestive enzymes: lipases, proteases
53. Nutritional support of chronic pancreatitis
54. Medical treatment of chronic pancreatitis: Antioxidants
- Strategies for surgical treatment of chronic pancreatitis (55–60)
55. Evidence of endoscopic and interventional treatment of chronic pancreatitis and pseudocysts
56. Indications and goals of surgical treatment
57. Pancreatic duct drainage procedure
58. Duodenum preserving pancreatic head resection
59. Major pancreatic resection
60. Laparoscopic surgery
61. Chronic pancreatitis: Late outcome after medical and surgical treatment
62. Management of pancreatic diabetes secondary to chronic pancreatitis
• Section 5: Autoimmune Pancreatitis
63. Epidemiology of autoimmune pancreatitis
64. Pathogenesis of autoimmune pancreatitis
65. Histology of autoimmune pancreatitis
66. Clinical manifestation of type 1 autoimmune pancreatitis
67. Clinical manifestation of type 2 autoimmune pancreatitis
68. Laboratory diagnosis of autoimmune pancreatitis
69. What is the evidence measuring immune markers
70. Imaging diagnosis of autoimmune pancreatitis
71. Medical treatment of autoimmune pancreatitis
72. Long-term outcomes after treatment of autoimmune pancreatitis
• Section 6: Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas
73. Epidemiology of cystic neoplasm of the pancreas
74. Histologic classification and staging of cystic neoplasm
75. Molecular mechanisms of cystic neoplasm
76. Clinical presentation of cystic neoplasm
77. Evaluation of cystic lesions using EUS, MRT, and CT
78. Cytologic evaluation of cystic neoplasm
79. Natural history of cystic neoplasm: IPMN, MCN, SCN, and SPN
80. Surveillance or surgical treatment in asymptomatic cystic neoplasm
- Local and Standard Surgical Treatment of Cystic Neoplasms (81–85)
81. Duodenum-preserving partial or total pancreatic head resection
82. Pancreatic middle segment resection of cystic neoplasms
83. Enucleation of cystic neoplasms: Indication and limitation
84. Standard surgical management of IPMN, MCN, SPN, and SCN lesions: An open approach
85. Surgical treatment of cystic neoplasm: Laparoscopic approach
86. Management of recurrence of cystic neoplasm
87. Long-term outcome after observation and surgical treatment of cystic neoplasm. What is the evidence?
• Section 7: Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer
88. Epidemiology of pancreatic cancer
89. Smoking, a risk for pancreatic cancer: Experimental and clinical data
90. Molecular understanding of development of ductal pancreatic cancer
91. Familial pancreatic cancer
92. Pathology of exocrine pancreatic tumors
93. Pancreatic cancer: Precancerous lesions
94. Clinical history and risk factors of pancreatic cancer
95. Pancreatic cancer within uncinate process: Radiologic and clinical characteristics
96. The role of EUS for diagnosis and differential diagnosis of neoplastic lesions
97. Radiological diagnosis of pancreatic cancer: CT, MRI
98. Screening of hereditary pancreatic cancer
99. The role of PET in diagnosis of pancreatic cancer and cancer recurrence
100. Tumor markers in pancreatic malignancies
101. The role of laparoscopy and peritoneal cytology in the management of pancreatic cancer
102. Clinical assessment and staging of advanced pancreatic cancer
- Surgical Treatment of Pancreatic Cancer (103–110)
103. Pancreatic cancer: Indications for resection
104. Pancreaticoduodenectomy for pancreatic cancer, short and long-term outcome after Kausch-Whipple and pylorus-preserving resection
105. Left pancreatectomy for body and tail cancer
106. Total pancreatectomy: Indication and limitations
107. Laparoscopic and robotic resection for pancreatic cancer
108. Extended radical surgery for pancreatic cancer
109. Palliative pancreaticoduodenectomy: Benefits and limitations
110. Bypass surgery for advanced pancreatic cancer
111. Endoscopic and interventional palliation of pancreatic cancer
112. Neoadjuvant treatment of pancreatic cancer: Downstaging results
113. Adjuvant chemotherapy in pancreatic cancer: First line and second line treatment: Benefits of survival
114. Immunotherapy for pancreatic cancer
115. Targeted therapies for pancreatic cancer
116. Palliative chemotherapy for advanced pancreatic cancer: Treatment modalities, side effects and benefits of survival
117. Management of pain in pancreatic cancer
118. Role of radio and proton beam therapy for pancreatic cancer
119. Management of cancer recurrence
120. Survival and late morbidity after resection of pancreatic cancer
• Section 8: Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas
121. Epidemiology and classification of neuroendocrine tumors of the pancreas
122. Pathology of neuroendocrine tumors
123. Molecular genetic of neuroendocrine tumors
124. Clinical manifestation of endocrine tumors of the pancreas
125. Evidence of hormonal, laboratory, biochemistric and instrumental diagnostics of neuroendocrine tumors of the pancreas
126. Pancreatic neuroendocrine tumors in multiple neoplasia syndromes
127. Non-functioning neuroendocrine tumors: Diagnosis and management principles
128. Medical and nucleotid treatment of neuroendocrine tumors of the pancreas
129. Interventional radiology treatment of neuroendocrine tumors
- Surgical Treatment of Endocrine Tumors of the Pancreas (130–136)
130. Enucleation of neuroendocrine tumors
131. Middle segment pancreatectomy and duodenum-preserving pancreatic head resection for neurendocrine tumors
132. Major oncologic resection for neuroendocrine tumors
133. Management of insulinoma
134. Gastrinoma: Evidence of medical and surgical treatment
135. Rare neuroendocrine tumors of the pancreas: Management and evidence of surgical treatment
136. Treatment of neuroendocrine tumors of the pancreas and biliary tract
137. Long-term outcome after treatment of endocrine tumors
• Section 9: Periampullary Tumors and others than Pancreatic Cancer
138. Periampullary tumors: Clinical presentation and diagnostic strategy
139. Histology and genetics of cancer of the papilla, distal common bile duct and duodenum
140. Adenoma and adenocarcinoma of the Ampulla of Vater: Diagnosis and management
141. Endoscopic treatment of adenomas of the Ampulla of Vater: Techniques, results, benefits and limitations
142. Surgical treatment of adenoma and cancer of papilla Vater
143. Surgical treatment of duodenal cancer
144. Surgical treatment of distal cholangiocarcinoma
145. Adjuvant and palliative chemotherapy of periampullary cancer: First line treatment and outcome
146. Long-term survival after resection of periampullary cancer
• Section 10: Transplantation of the Pancreas
147. Transplantation of pancreatic islets
148. Transplantation of the pancreas
Index, xxx

This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations.
Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors.

• The most encyclopedic book on the pancreas—providing outstanding and clear guidance for the practicing clinician
• Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management
• Completely updated with brand new chapters
• Over 500 downloadable illustrations
• An editor and author team of high international repute who present global best-practice

The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.

• HANS G. BEGER, MD, FACS(Hon), JSS(Hon), CSS(Hon), Founding Editor, Professor Emeritus of Surgery, c/o University of Ulm, Ulm, Germany
• ANDREW L. WARSHAW, MD, FACS, FRCSEd(Hon), W. Gerald Austen Distinguished Professor of Surgery, Harvard Medical School, Surgeon-in-Chief Emeritus, Massachusetts General Hospital, Boston, MA, USA
• RALPH H. HRUBAN, MD, Baxley Professor and Director, The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
• MARKUS W. BÜCHLER, MD, Professor of Surgery and Chair, Department of Surgery, University of Heidelberg, Heidelberg, Germany
• MARKUS M. LERCH, MD, FRCP, Professor and Chair, Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
• JOHN P. NEOPTOLEMOS, MA, MB, BCHIR, MD, FRCS, FMEDSCI, Professor of Surgery, Department of Surgery, University of Heidelberg, Heidelberg, Germany
• TOORU SHIMOSEGAWA, MD, PhD, Professor, Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
• DAVID C. WHITCOMB, MD, PhD, Professor of Medicine, Cell Biology & Physiology, and Human Genetics, Director, UPMC Precision Medicine Service, University of Pittsburgh and UPMC, Pittsburgh, PA, USA