A HANDBOOK OF VITILIGO AND COLOR ATLAS. 2ND EDITION

1. Introduction 1
Definition of vitiligo 1
Origin of the word vitiligo 1
2. Historical Background 3
3. Clinical Aspects of Vitiligo 5
Characteristics of vitiligo lesions 5
Clinical types of vitiligo 6
Course of vitiligo 7
Factors affecting progression of vitiligo 8
Clinical manifestations 8
Behaviorism of vitiligo 9
Factors affecting progression of vitiligo 9
4. Genetic Susceptibility in Vitiligo and Familial Aggregation of Vitiligo 10
5. The Psychosocial Impacts of Vitiligo 12
6. Vitiligo with Disorders of Other Systems 14
Vitiligo and endocrine dysfunction 14
7. Incidence of Vitiligo 16
Genetics and familial inheritance prevalence in vitiligo 17
Epidemiology 17
8. Classification 20
Clinical classification of vitiligo: discussion and clarification 21
Classification of vitiligo depending on the activity of disease 22
9. Etiology of Vitiligo 23
Role of vitamin C 23
Discussion 25
10. Color of the Skin 26
Classification of melanin pigments 26
Melanin pigmentary pathway 26
Stages in the development of melanin granules 31
11. Hypothesis in the Causation of Vitiligo 35
Emergence of few new hypotheses 38
12. Diagnosis and Differential Diagnosis of Vitiligo 41
Diagnosis 41
Differential diagnosis of vitiligo 43
13. Chemically-induced Leukoderma 46
Modes 46
Selected chemicals associated with chemical leukoderma 47
Treatment 47
Course and prognosis 48
14. Investigations for Vitiligo 49
Histology 49
Electron microscopy 49
Immunocytochemistry 49
15. Treatment of Vitiligo 51
General measure 51
Medical 51
General consideration 55
Topical puva 59
Puva therapy 60
Photochemotherapy 60
Puvasol 62
Oral treatment 62
Specific instruction for local/topical treatment 63
Options for ultraviolet-based therapy 64
Surgical 64
Tattooing in vitiligo 67
Dermabrasion in vitiligo 67
Laser therapy for vitiligo 67
Local chemical irritation/counter irritations in vitiligo 68
Local photosensitizers in vitiligo 68
Placental extracts in vitiligo 68
Alternatives 68
Psychology counseling 68
Social aspects in vitiligo 68
No treatment advice 69
Mini pulse therapy for vitiligo 69
Levamisole in vitiligo 69
Cyclophosphamide in vitiligo 69
Rational and scientific approach 69
Summary of treatment strategy of vitiligo 69
16. Recent Knowledge 71
17. Vitiligo in Children 75
Differential diagnosis 75
Treatment 75
18. Conclusion 77
Bibliography 79
Color Atlas 87
Index 109

Vitiligo is a long-term condition that causes pale, white patches to develop on the skin due to lack of a chemical called melanin. It can affect any area of the skin, but most commonly occurs on skin exposed to the sun, such as the face, neck and hands (NHS Choices).
This new edition has been fully revised to provide dermatologists with the latest information on the diagnosis and treatment of vitiligo.
Presented with a step by step approach, the book begins with an overview of the condition’s historical background, genetic susceptibility, and psycho-social aspects.
The following sections discuss incidence of vitiligo with disorders of other body systems, aetiology, skin colour, diagnosis, and treatment. Complete chapters are dedicated to chemically induced leukoderma and vitiligo in children.
The second edition features many new photographs, flowcharts and theories on the cause of vitiligo, as well as new treatment methods including lasers, tattooing, and surgery.

Key points
• Fully revised, new edition providing latest information on vitiligo
• Complete chapters dedicated to chemically induced leukoderma and vitiligo in children
• Second edition features many new photographs, flowcharts, theories and treatment methods
• Previous edition (9788180611605) published in 2003

Author information
SK Punshi MBBS DDV FIMS FDS. Senior Consultant Dermatologist, Rajkamal Chowk, Amravati, Maharashtra, India