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• Section I Basic Concepts
Chapter 1 Historical Perspectives of Allergen Immunotherapy
David Fitzhugh, Sheldon G. Cohen (Deceased), and Richard Evans III (Deceased)
Chapter 2 Aeroallergen Sampling
Estelle Levetin and Josh D. McLoud
Chapter 3 Definition of an Allergen (Immunobiology)
Lauren Fine
Chapter 4 Allergen Nomenclature
Heimo Breiteneder, Richard Goodman, Martin D. Chapman, and Anna Pomés
Chapter 5 Immunologic Response to Various Forms of Allergen Immunotherapy
Umit Murat Sahiner, Mohamed H. Shamji, Sakura Sato, Ozge Soyer, Stephen J Till, Motohiro Ebisawa, Mübeccel Akdis, and Stephen R. Durham
Chapter 6 In Vivo Testing
Richard W. Weber
Chapter 7 Serologic (in vitro) and Component Testing Methods in the Diagnosis of Human Allergic Disease
Robert G. Hamilton
Chapter 8 Nasal, Bronchial, Conjunctival, and Food Challenge Techniques and Epicutaneous Immunotherapy of Food Allergy
Mark W. Tenn, Matthew Rawls, Babak Aberumand, and Anne K. Ellis
Chapter 9 Local Mucosal Allergic Disease
Ibon Eguiluz-Gracia, Paloma Campo, and Carmen Rondón
• Section II Allergens: Inhalation, Ingested, and Injected
Chapter 10 Tree Pollen Allergens
Rosa Codina, Fernando Pineda, and Ricardo Palacios
Chapter 11 Grass Pollen Allergens
Robert E. Esch
Chapter 12 Weed Pollen Allergens
Michael Hauser, Gabriele Gadermaier, Sabrina Wildner, Lisa Pointner, Michael Wallner, and Fatima Ferreira
Chapter 13 Fungal Allergens
Robert Esch, Jonathan A. Bernstein, and Hari Vijay
Chapter 14 Mite Allergens
Enrique Fernández-Caldas, Leonardo Puerta, Luis Caraballo, Victor Iraola, and Richard F. Lockey
Chapter 15 Cockroach and Other Inhalant Insect Allergens
Anna Pomés and Coby Schal
Chapter 16 Mammalian Allergens
Tuomas Virtanen and Marja Rytkönen-Nissinen
Chapter 17 Food Allergens
Anusha Penumarti and Mike Kulis
Chapter 18 Hymenoptera Allergens
Rafael I. Monsalve, Te Piao King, and Miles Guralnick
Chapter 19 Biting Insect and Tick Allergens
Donald R. Hoffman and Jennifer E. Fergeson
Chapter 20 Occupational Allergens
Loida Viera-Hutchins, Andrew M. Smith, and David Bernstein
• Section III Immunotherapy Techniques: Production, Preparation and Administration of Allergen Immunotherapy
Chapter 21 Manufacturing Pollen and Fungal Extracts
Robert E. Esch, Rosa Codina, Fernando Pineda, and Ricardo Palacios
Chapter 22 Manufacturing Arthropod and Mammalian Allergen Extracts
Enrique Fernández-Caldas, Eva Abel Fernández, Jonathan Kilimajer, and Seong H. Cho
Chapter 23 Manufacturing Food Extracts
Natalie A. David, Anusha Penumarti, and Jay E. Slater
Chapter 24 Regulation of Allergen Extracts in the United States
Jennifer Bridgewater, Jay E. Slater, and Ronald L. Rabin
Chapter 25 Manufacturing and Standardizing Allergen Extracts in Europe
Jørgen Nedergaard Larsen, Christian Gauguin Houghton, Manuel Lombardero Vega, Hendrik Nolte, and Henning Løwenstein
Chapter 26 Indications for and Preparing and Administering Subcutaneous Allergen Vaccines
Harold S. Nelson
Chapter 27 Preparing and Administering Sublingual Allergen Vaccines
Miguel Casanovas, Jonathan Kilimajer, and Enrique Fernández-Caldas
Chapter 28 Sublingual and Oral Food Immunotherapy: Indications, Preparation and Administration
Whitney Block, Sayantani B. Sindher, Vanitha Sampath, and Kari Nadeau
Chapter 29 Indications for and Preparing and Administering Hymenoptera Vaccines
David B.K. Golden, Farnaz Tabatabaian, Ulrich Müller-Gierok, and Richard F. Lockey
Chapter 30 Recombinant and Modified Vaccines and Adjuvants Used for Allergen Immunotherapy
Jeffrey Stokes and Thomas B. Casale
• Section IV Clinical Application of Allergen Imunotherapy and Biological Therapy for Allergic Diseases
Chapter 31 Adherence and Cost-Effectiveness of Subcutaneous Immunotherapy and Sublingual Immunotherapy
Dana V. Wallace and John Oppenheimer
Chapter 32 Biologics in Allergic Disease
Tara Saco and Farnaz Tabatabaian
Chapter 33 Unproven and Epicutaneous and Other Investigational Forms of Immunotherapy
Haig Tcheurekdjian and Abba I. Terr
• Section V Recognition, Management, and Prevention of Adverse Effects of Allergen Immunotherapy
Chapter 34 Adverse Effects and Fatalities Associated with Allergen Skin Testing and Subcutaneous Allergen Immunotherapy
Andrew S. Bagg and Richard F. Lockey
Chapter 35 Recognition, Prevention, and Treatment of Adverse Effects Associated with Sublingual Immunotherapy
Giovanni Passalacqua, Diego Bagnasco, and Walter Canonica
Chapter 36 Recognition, Prevention, and Treatment of Adverse Effects Associated with Oral Allergen Immunotherapy
Jennifer A. Dantzer and Robert A. Wood
Chapter 37 Instructions and Consent Forms for Subcutaneous Allergen Immunotherapy
Shiven S. Patel, Linda Cox, and Richard F. Lockey
Chapter 38 Recognition, Treatment, and Prevention of Systemic Allergic Reactions and Anaphylaxis
Emma Westermann-Clark, Stephen F. Kemp, and Richard D. deShazo

The sixth edition of Lockey and Ledford's Allergens and Allergen Immunotherapy continues to provide comprehensive coverage of all types of allergens and allergen vaccines, providing clinicians the essential information they need to accurately diagnose and manage all allergic conditions. With new and updated chapters, the sixth edition is the most up-to-date, single resource on allergy and immunotherapy.

Key Features
• Completely revised and updated
• Detailed single source reference on allergy and immunotherapy
• Reorganized to provide clinicians with essential information to make diagnoses and offer the best treatments

• Richard F. Lockey, MD, MS, is Distinguished University Health Professor, Professor of Medicine, Pediatrics and Public Health, Joy McCann Culverhouse Chair of Allergy and Immunology, and Director, Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida.
• Dennis K. Ledford, MD, is Professor of Medicine and Pediatrics, Mabel and Ellsworth Simmons Professor, University of South Florida Morsani College of Medicine, and Chief, VA Section of Allergy/Immunology, James A. Haley Veterans' Hospital, Tampa, Florida.