ANIMAL MODELS OF ACUTE NEUROLOGICAL INJURY. 2ND EDITION

• Preface
• Animal Protocol
• Anesthesia and Analgesia for Research Animals
• Rodent Surgical Procedures and Tissue Collection
• Brain Monitoring
• Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies: An Update
• Four Vessel-Occlusion Model in Rats
• Rat Model of Global Cerebral Ischemia: Two Vessel-Occlusion (2VO) Model of Forebrain Ischemia
• Rodent Model of Pediatric Asphyxial Cardiac Arrest
• Transient Middle Cerebral Artery Occlusion Model in Rodents
• Targeted Occlusion to Surface and Deep Vessels in Neocortex Via Linear and Nonlinear Optical Absorption
• Intraluminal Middle Cerebral Artery Occlusion Model in Mice
• Inducing Hemorrhagic Transformation following Middle Cerebral Artery Occlusion via Acute Hyperglycemia in Rats
• Cerebral Palsy Model of Uterine Ischemia
• Model of Neonatal Focal Cerebral Ischemia-Reperfusion
• Monofilament Perforation Subarachnoid Hemorrhage Rat Model
• Filament Perforation Subarachnoid Hemorrhage Mouse Model
• Non-Human Primate Model of Cerebral Vasospasm
• Blood Injection Intracerebral Hemorrhage Rat Model
• Collagenase Model of Intracerebral Hemorrhage in Rats
• A Rat Model of Cerebellar Hemorrhage using Bacterial Collagenase Injection
• Blood Injection Intracerebral Hemorrhage Mouse Model
• Blood Injection Intracerebral Hemorrhage Pig Model
• Collagenase Induced Pontine Hemorrhage in Rats
• Germinal Matrix Hemorrhage Neonatal Rat Model Using Bacterial Collagenase Injection
• Fluid Percussion Injury Model
• Controlled Cortical Impact Model of Experimental Brain Trauma
• Mild Blast-induced Traumatic Brain Injury Model
• Rat Model of Surgical Brain Injury
• MASCIS Spinal Cord Contusion Model
• ESCID Spinal Cord Contusion Model
• Cervical Hemicontusion Spinal Cord Injury Model
• Applications of the Infinite Horizon Spinal Cord Contusion Injury Model
• Clip Impact-Compression Model
• Method of Spinal Cord Contusion Injury Created by Tissue Displacement
• Experimental Laceration Spinal Cord Injury Model in Rodents
• Rodent Spinal Cord Demyelination Models
• Spinal Cord Lateral Hemisection and Implantation of Guidance Channels
• Spinal Root Avulsion and Repair
• Index

Acute neurological injuries are devastating events that affect all individuals across the spectrum of human life. Understanding the mechanisms of cell death after these incidents will help to develop pharmacological agents and therapeutic interventions to reduce or prevent the damage. Many studies have been conducted and new exciting discoveries have been reported. However, only limited treatments are available today for the victims of acute neurological injuries. More investigations are needed to explore the underlying mechanisms of neuronal injury following the insult and to translate them into preclinical and clinical settings. Reliable animal models are the key for experimental neurobiology. To date, many animal models for acute neurological injuries have been developed. But large variations in experimental outcomes exist between laboratories even using the same animal model, making the comparison and replication impossible and jeopardizing advances in the field. This variation is largely due to the lack of a standard manual detailing the methodology in animal models.
Since publishing the first edition of this book in 2009, much progress has been made in the field. The advance in translational medicine has generated new challenges to neuroscientists. The reproducibility of the results of preclinical research is one of the recognized obstacles, which further emphasizes the importance of standardizing the animal models. In this second edition, we have included 21 new and revised chapters to better illustrate the earlier models and to introduce new animal models that reflect the expansion of preclinical research in acute neurological disorders.

Features
• Provides updated detailed information on models from the 1st edition
• Includes chapters on additional models that were not in the 1st edition
• Features full-color photographs of key surgical steps