ANTIBIOTIC PHARMACODYNAMICS

1. General Concepts of Pharmacodynamics for Anti-infective Agents
2. In Vitro Pharmacodynamic Models to Evaluate Anti-infective Pharmacodynamics
3. Animal Models to Evaluate Anti-infective Pharmacodynamics
4. Pharmacodynamic Issues in Antibiotic Combinations
5. Methodologies for Protein Binding Determination in Anti-infective Agents
6. Evaluation of Exposure-Response Relationships Using Clinical Data: Basic Concepts and Applications
7. Toxicokinetics and Toxicodynamics of Anti-infective Agents
8. Pharmacodynamics of Fluoroquinolones
9. Aminoglycoside Pharmacodynamics
10. Polymyxin Pharmacokinetics and Pharmacodynamics
11. Vancomycin Pharmacodynamics: Optimal vs. Controversial
12. Pharmacodynamics of Lipoglycopeptides
13. Pharmacodynamics of Daptomycin
14. Pharmacodynamics of Macrolides, Azalides, and Ketolides
15. Antifungal Pharmacokinetics and Pharmacodynamics
16. Pharmacokinetics and Pharmacodynamics of the Tuberculosis Drugs
17. Pharmacodynamics of Antimalarial Agents
18. Pharmacodynamics of Antiviral Agents
19. Pharmacodynamics of Antiretroviral Agents
20. Implementing a Continuous or Prolonged Infusion Beta-Lactam Program in the Hospital Setting
21. Pharmacodynamic Considerations in Critically Ill Patients
22. Pharmacodynamic Considerations and Special Populations: Pediatrics
23. Pharmacodynamics and Obesity
24. Drug Development Process and Regulatory Science
25. Antibiotic Stewardship and Applications of Pharmacodynamics

This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab.
Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.

Features
• Forges a path toward new antibiotic development processes for licensing new antibiotics
• Offers state-of-the-art contributions from world renowned experts
• Explores how antibiotics might be optimally used in a clinical situation
• Features practical, reproducible methods and key implementation advice