ANTIBIOTIC PHARMACOKINETIC/PHARMACODYNAMIC CONSIDERATIONS IN THE CRITICALLY ILL

1. Basic Pharmacokinetic Principles
2. Antibiotic Pharmacodynamics
3. Physiological Manifestations of Critical Illness
4. Dosing in Obese Critically Ill Patients
5. Hypoalbuminaemia and Altered Protein Binding
6. Acute Kidney Injury and Renal Replacement Therapy
7. Augmented Renal Clearance
8. Antibiotic Dosing During Extracorporeal Membrane Oxygenation
9. Therapeutic Drug Monitoring: More Than Avoiding Toxicity
10. Generic and Optimized Antibacterial Dosing Strategies in the Critically Ill
11. Antifungal PK/PD in the Critically Ill
12. Antibiotic Dosing in Pediatric Critically Ill Patients
13. Antibiotic Stewardship in the Intensive Care Unit

This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics.
Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.

Features
• Combines clinical and pharmacological information on the treatment of infection in a single reference
• Provides international, expert perspectives on the management of infection in the critically ill
• A clinical focus informs trainees and senior clinicians alike