AUTONOMIC INNERVATION OF THE HEART

This book explains in detail the potential value of the hybrid modalities, SPECT-CT and PET-CT, in the imaging of cardiac innervation in a wide range of conditions and diseases, including ischemic heart disease, diabetes mellitus, heart failure, amyloidosis, heart transplantation, and ventricular arrhythmias. Imaging of the brain-heart axis in neurodegenerative disease and stress and of cardiotoxicity is also discussed. The roles of the various available tracers are fully considered, and individual chapters address radiopharmaceutical development under GMP, imaging physics, and kinetic modeling software. Highly relevant background information is included on the autonomic nervous system of the heart and its pathophysiology, and in addition future perspectives are discussed.
Awareness of the importance of autonomic innervation of the heart for the optimal management of cardiac patients is growing, and there is an evident need for objective measurement techniques or imaging modalities. In this context,Autonomic Innervation of the Heart will be of wide interest to clinicians, researchers, and industry.

Table of contents (23 chapters)
1.The Autonomic Nervous System of the Heart
2.Electrophysiology and Pathophysiology of the Autonomic Nervous System of the Heart
3.Development of Heart Failure and the Role of the Autonomic Nervous System of the Heart
4.Role of the Autonomic Nervous System in Ventricular Arrhythmias During Acute Myocardial Ischemia and Infarction
5.Tracers for Sympathetic Cardiac Neurotransmission Imaging
6.Imaging the Parasympathetic Cardiac Innervation with PET
7.Tracer Application in Cardiovascular Imaging: A Triple Jump
8.General Principles of PET/CT and Autonomic Innervation of the Heart Including Kinetics and Software
9.General Principles of
10.Preclinical Evaluations of Cardiac Sympathetic Innervation Radiotracers
11.PET Imaging of Myocardial ß-Adrenoceptors
12.Autonomic PET-CT Imaging in Heart Failure
13.Conventional Radionuclide Imaging of Autonomic Function in Heart Failure
14.Autonomic Imaging in Myocardial Ischemia
15.Imaging the Cardiac Automatic Nervous System in Diabetes Mellitus
16.Imaging of the Autonomic Nervous System in Cardiac Amyloidosis
17.Autonomic Imaging in Heart Transplantation
18.Autonomic Imaging in Ventricular Arrhythmias
19.Imaging Sympathetic Innervation of the Heart: Therapeutic Strategies SPECT/CT and PET/CT
20.Autonomic Imaging: The Cardiorenal Axis
21.Imaging the Functional Brain-Heart Axis: Neurodegenerative Diseases
22.Imaging the Functional Brain-Heart Axis: Mental Stress and Cardiac Dysfunction
23.Autonomic Imaging Cardiotoxicity with