BARILE´S CLINICAL TOXICOLOGY. 3RD EDITION

• Section I Introduction to Basic Toxicological Principles
Chapter 1 Introduction.3
Chapter 2 Risk Assessment and Regulatory Toxicology. 11
Chapter 3 Therapeutic Monitoring of Adverse Drug Reactions (ADRs).27
Chapter 4 Classification of Toxins in Humans 47
Chapter 5 Exposure69
Chapter 6 Effects 79
Chapter 7 Dose–Response. 91
Chapter 8 Descriptive Animal Toxicity Tests99
Chapter 9 In Vitro Alternatives to Animal Toxicity 105
Chapter 10 Toxicokinetics. 111
Chapter 11 Chemical– and Drug–Receptor Interactions. 139
Chapter 12 Toxicogenomics. 151
• Section II Toxicity of Therapeutic Agents
Chapter 13 Sedative/Hypnotics 167
Chapter 14 Opioids and Related Agents 183
Chapter 15 Sympathomimetics203
Chapter 16 Hallucinogenic Agents225
Chapter 17 Anticholinergic and Neuroleptic Drugs 251
Chapter 18 Acetaminophen, Salicylates, and Nonsteroidal Anti-
Chapter 19 Anabolic–Androgenic Steroids.287
Chapter 20 Cardiovascular Toxicology299
Chapter 21 Antineoplastic Agents. 317
Chapter 22 Vitamins 329
Chapter 23 Herbal Remedies. 343
• Section III Toxicity of Nontherapeutic Agents
Chapter 24 Alcohols and Aldehydes 361
Chapter 25 Gases. 381
Chapter 26 Metals 401
Chapter 27 Aliphatic and Aromatic Hydrocarbons. 439
Chapter 28 Insecticides 451
Chapter 29 Herbicides467
Chapter 30 Rodenticides 477
Chapter 31 Chemical Carcinogenesis and Mutagenesis489
Chapter 32 Reproductive and Developmental Toxicity.505
Chapter 33 Radiation Toxicity. 523
Chapter 34 Chemical and Biological Threats to Public Safety. 535
Index. 555

As with the two previous editions, Barile’s Clinical Toxicology: Principles and Mechanisms, Third edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. With special emphasis placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs, the new edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. The new edition presents the latest, up-to-date protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology. In addition, the effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered.

KEY FEATURES
• Discusses source of the drug or chemical, pharmacological and toxicological mechanisms of action, detection, identification, and treatment
• Examines the complex interactions associated with clinical toxicological events
• Emphasizes the signs and symptoms of diseases and pathology caused by toxins and clinical drugs
• Covers effect of toxins on body systems and drug-induced adverse reactions
• Offers a unique perspective for toxicology, pharmacology, pharmacy and health professions students

The target audience for this book is undergraduate and graduate toxicology students, clinical pharmacy (Pharm.D.) students, emergency medical personnel, regulatory agencies, and other related health science professionals. It satisfies an essential need for a concise yet detailed authoritative, fundamental text addressing the current principles of clinical toxicology.

Author
Frank A. Barile, PhD, is Professor in the Toxicology Division and past chairman of the Department of Pharmaceutical Sciences, St. John’s University College of Pharmacy and Health Sciences, New York.
Dr. Barile received his BS in Pharmacy, MS in Pharmacology, and PhD in Toxicology at St. John’s University. After doing a postdoctoral fellowship in Pulmonary Pediatrics at the Albert Einstein College of Medicine, Bronx, NY, he moved to the Department of Pathology, Columbia University—St. Luke’s Roosevelt Hospital, NY, as a research associate. In these positions, he investigated the role of pulmonary toxicants in collagen metabolism in cultured lung cells. In 1984, he was appointed assistant professor in the Department of Health Sciences at City University of NY. Sixteen years later, he rejoined St. John’s University in the Department of Pharmaceutical Sciences in the College of Pharmacy.