BIOLOGY AND TREATMENT OF LEUKEMIA AND BONE MARROW NEOPLASMS

1. Advances in Diagnosis and Risk Stratification of Acute Myeloid Leukemia and Myelodysplastic Syndromes
2. Genetics and Diagnostic Approach to Lymphoblastic Leukemia/Lymphoma
3. Acute Promyelocytic Leukemia: Update on Risk Stratification and Treatment Practices
4. Current and Emerging Therapies for Acute Myeloid Leukemia
5. Current Management and New Developments in the Treatment of ALL
6. CML Chapter
7. Current Management and New Developments in the Treatment of Myelodysplastic Syndrome
8. Chronic Lymphocytic Leukemia (CLL): Biology and Therapy
9. Biology and Current Treatment of Myeloproliferative Neoplasms
10. Systemic Mastocytosis: Advances in Diagnosis and Current Management
11. Chimeric Antigen Receptor (CAR) T Cell Therapy for B-Acute Lymphoblastic Leukemia (B-ALL)

This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.