BIOMARKERS IN CANCER SCREENING AND EARLY DETECTION

• Part I Foundations of Biomarker Research
1 Nuts and Bolts of Biomarker Research, 3
2 Cancer Genome Methylation: Biology, Biomarker and Therapeutic Opportunities, 16
3 MicroRNA Biomarkers for Early Detection of Cancer, 27
4 Inflammation and Cancer, 37
5 Exosomes: A Valuable Biomedical Tool in Biomarker Discovery and Development, 50
6 Epithelial-to-Mesenchymal Transition (EMT): Clinical Implications, 64
• Part II State-of-the-Science in Organ-Specific Biomarker Research
7 Breast Cancer, 77
8 Ovarian Cancer, 93
9 Esophageal Cancer Biomarkers, 104
10 Predictive Biomarkers for Therapy in Adenocarcinoma of the Upper Digestive Tract, 118
11 Pancreatic Cancer, 130
12 Colon Cancer, 141
13 Prognostic and Predictive Biomarkers for Colorectal Cancer, 151
14 Early Detection of Lung Cancer, 163
15 Commonalities in Lung Cancer and COPD, 185
16 Prostate Cancer, 197
• Part III Biomarkers, Screening and Precision Health: Implications for Public Health
17 Improving the Clinical Validity of Biomarker Research in Cancer Detection, 209
18 Cancer Overdiagnosis, Ramifications and Research Strategies, 220
19 Predictive Markers and Driver Genes From Treatment Trials: Potential Utility For Early Diagnosis, 231
20 Statistical Consideration in Predictive and Prognostic Markers, 245
21 Clinical Validation of Molecular Biomarkers in Translational Medicine, 256
22 Cancer Biomarker Assays: Performance Standards, 267
23 Bioethics and Cancer Biomarker Research, 277
24 Colon Cancer Screening, 283

Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment.
• Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers
• Provides immediately actionable information and hopefully also inspiration to move discovery and clinical application forward
• Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers
Authors
• Sudhir Srivastava, Ph.D., MPH Senior Scientific Officer, Chief, Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
• Translational Oncology Series
Series Editors
ROBERT C. BAST, MD, Vice President for Translational Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
• MAURIE MARKMAN, MD, Senior Vice President for Clinical Affairs, Cancer Treatment Centers of America, Clinical Professor of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA
• ERNEST HAWK, MD, MPH, Vice President, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA