BIOMARKERS IN CARCINOMA OF UNKNOWN PRIMARY

1. Definition of “Tissue-Based Biomarker,” its Place in Medicine, and Molecular Pathology
2. The Concept and Mechanisms of Metastasis
3. Biomarkers in Skin Carcinomas
4. Biomarkers in Head and Neck Carcinomas
5. Biomarkers in Pulmonary Carcinomas
6. Biomarkers in Endocrine Organ Carcinomas
7. Biomarkers in Gastrointestinal System Carcinomas
8. Biomarkers in Hepatopancreatobiliary Carcinomas
9. Biomarkers in Urinary Tract and Male Genital System Carcinomas
10. Biomarkers in Gynecologic Carcinomas
11. Biomarkers in Breast Carcinomas
12. Diagnostic Approach According to More Frequent Metastatic Sites: Liver, Lung, Bone, and Lymph Nodes
13. Diagnostic Approach According to Uncovered Metastatic Sites: Mediastinum-Thymus, Peritoneum, Central Nervous System, and Soft Tissue
14. Management of the Patients with Carcinoma of Unknown Primary and the Role of Biomarkers
15. Treatment Approach to Carcinomas of Unknown Primary

This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.

Features
• Presents a holistic perspective with algorithmic approaches based on system carcinomas and metastatic region
• Provides all diagnostic, prognostic and predictive biomarkers in all carcinomas
• Covers immunhistochemical and also molecular pathologic biomarkers

Authors
• Sulen Sarioglu graduated from the Ankara Science Lise (1982) and Hacettepe University Faculty of Medicine (1988), Turkey. Until 1992, she worked as a resident in pathology. From 1992 to 1994, she worked at the Department of Pathology at the Ankara Oncology Hospital, Turkey. In 1999, she developed her skills further at the University of Birmingham. She has worked at Dokuz Eylul University (DEU) Department of Pathology since 1994, where she has been a full-professor since 2002. She is a member of the European Society of Pathology and the Renal Pathology Society, the European Society of Pathology’s Head and Neck Pathology and Nephropathology Working Groups. She is the former Chair of DEU Department of Pathology (2015-2018), the Turkish Federation of Pathology Societies Head and Neck Working Group (2008-2012), Nephropathology Working Group (2012-2014) and Information Technologies Working Group (2014-2018). She is the previous chair of DEU Health Sciences Institute Department of Molecular Pathology. She is the author of one international book in pathology (Tumor Deposits by Springer Nature), three national scientific books, has edited two national books in pathology, and has authored/co-authored more than 300 scientific publications.
• Ozgul Sagol graduated from Bornova Anatolian High School (1985) and Ege University Faculty of Medicine (1991), Turkey. She accomplished her pathology residency in Dokuz Eylul University Faculty of Medicine in 1996. She developed her skills further at the Pittsburgh University in 1998. She has been working at Dokuz Eylul University Department of Pathology since 1996, where she has been a full-professor since 2006. She is the current chair of the Department of Pathology in Dokuz Eylul University Hospital. She is a faculty member in PhD Program of DEU Health Sciences Institute Department of Molecular Pathology since 2018. She is a member of Ege Pathology Society and the co-chair of the Turkish Federation of Pathology Societies Hepatopancreatobiliary Pathology Working Group. She is one of the authors of three national and one international scientific books and has authored/co-authored more than 150 scientific publications.
• Anil Aysal Agalar graduated from Bursa Science High School (2000) and Ege University Faculty of Medicine (2007), Turkey. She accomplished her pathology residency in Dokuz Eylul University Faculty of Medicine in 2011. She developed her skills at the University of California, San Francisco in 2009 as a research fellow. Between 2011-2015 she worked as a pathologist in two public hospitals. She has been working at Dokuz Eylul University Department of Pathology as an assistant professor since 2015. She is currently continuing her PhD education in molecular pathology at DEU Health Sciences Institute Department of Molecular Pathology. She is a member of Ege Pathology Society. She has authored/co-authored 20 scientific publications.