BIOMARKERS OF HIP IMPLANT FUNCTION

• Part I: Foundational information
1. Introduction to hip implants and biomarker testing
Ilona Swiatkowska, Shiraz A. Sabah, Laura-Maria Horga and Alister J. Hart
2. Degradation of metal hip implants
Andrew R. Beadling, Anne Neville and Michael G. Bryant
3. Implant metals and their potential toxicity
Ilona Swiatkowska
• Part II: Assessing hip implant function and risk of local and systemic adverse reactions
4. Markers of hip implant degradation: analytical considerations and clinical interpretation
Pascal-Andre Vendittoli, Angela Styhler and Ilona Swiatkowska
5. Biomarkers of compromised implant fixation
Reshid Berber, Benjamin Bloch, Peter James and Andrew Manktelow
6. Biomarkers of periprosthetic joint infection
Marc-Olivier Kiss and Vincent Masse
7. Hip implants and systemic cobalt toxicity: a comprehensive review with case studies
Ilona Swiatkowska, Obakanyin J. Akinfosile, Ravindra V. Badhe, Mark Barba, Mathew T. Mathew and Divya Bijukumar
• Part III: Translational effect of biomarker research on clinical practice
8. Clinical guidelines on the use of biomarkers for surveillance of hip replacements
Harry Hothi, Reshid Berber, Shiraz A. Sabah and Alister J. Hart

Covers all established and candidate biomarkers of hip implant wear, periprosthetic infection, and toxicity
Summarises recent research into blood titanium levels associated with well-functioning and malfunctioning hip implants to aid implant revision decisions
Reviews over 50 cases of suspected systemic cobalt toxicity to raise awareness of its symptoms and clinical presentation, and guide investigations and treatment decisions.