BIOMATERIALS FROM NATURE FOR ADVANCED DEVICES AND THERAPIES

CONTRIBUTORS xix
PREFACE xxix

• PART I
1 Collagen-Based Porous Scaffolds for Tissue Engineering 3
2 Marine Collagen Isolation and Processing Envisaging Biomedical Applications 16
3 Gelatin-Based Biomaterials for Tissue Engineering and Stem Cell Bioengineering 37
4 Hyaluronic Acid-Based Hydrogels on a Micro and Macro Scale 63
5 Chondroitin Sulfate as a Bioactive Macromolecule for Advanced Biological Applications and Therapies 79
6 Keratin 93
7 Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering 106
8 Silk: A Unique Family of Biopolymers 127
9 Silk Protein Sericin: Promising Biopolymer for Biological and Biomedical Applications 142
10 Fibrin 159
11 Casein Proteins 176
12 Biomaterials from Decellularized Tissues 190
13 Demineralized Bone Matrix: A Morphogenetic Extracellular Matrix 211
• PART II
14 Recent Developments on Chitosan Applications in Regenerative Medicine 223
15 Starch-Based Blends in Tissue Engineering 244
16 Agarose Hydrogel Characterization for Regenerative Medicine Applications: Focus on Engineering Cartilage 258
17 Bioengineering Alginate for Regenerative Medicine Applications 274
18 Dextran 307
19 Gellan Gum-based Hydrogels for Tissue Engineering Applications 320
• PART III
20 Biomedical Applications of Polyhydroxyalkanoates 339
21 Bacterial Cellulose 384
• PART IV
22 Molecularly Imprinted Cryogels for Protein Purification 403
23 Immunogenic Reaction of Implanted Biomaterials from Nature 429
24 Chemical Modification of Biomaterials from Nature 444
• PART V
25 Processing of Biomedical Devices for Tissue Engineering and Regenerative Medicine Applications 477
26 General Characterization of Physical Properties of Natural-Based Biomaterials 494
27 General Characterization of Chemical Properties of Natural-Based Biomaterials 517
28 In Vitro Biological Testing in the Development of New Devices 532
29 Advanced In-Vitro Cell Culture Methods Using Natural Biomaterials 551
30 Testing Natural Biomaterials in Animal Models 562
• PART VI
31 Delivery Systems Made of Natural-Origin Polymers for Tissue Engineering and Regenerative Medicine Applications 583
32 Translational Research into New Clinical Applications 612
33 Challenges and Opportunities of Natural Biomaterials for Advanced Devices and Therapies 629
34 Adhesives Inspired by Marine Mussels 634
35 Final Comments and Remarks 649

INDEX 651

The book provides a high-level overview of natural biomaterials for medical applications, covering topics such as tissue engineering with collagens or gelatines and natural materials for protein purification and drug delivery. The following parts focus on the characterization and applications of natural biomaterials in biomedical research and medical practice.