BIOMEDICAL NANOMATERIALS

1 Pharmacokinetics and Pharmacodynamics (PK/PD) of Bionanomaterials 1
2 Targeted Dendrimers for Cancer Diagnosis and Therapy 61
3 Polymeric Micelles for Drug Delivery 87
4 Polymeric Micelle-Based Nanomedicine 99
5 Microfluidics Applications in Cancer Drug Delivery 117
6 Antibody–Drug Conjugates 149
7 Nano-Photosensitizer for Imaging-Guided Tumor Phototherapy 177
8 Quantum Dots for Cancer Diagnosis 207
9 Luminescent Gold Nanoclusters for Biomedical Diagnosis 227
10 Nanographene in Biomedical Applications 251
11 Molecular Imprinting Technique for Biomimetic Sensing and Diagnostics 283
12 Magnetic Nanostructures for MRI-Based Cancer Detection 327
13 Magnetic Iron Oxide Nanoparticles: Bioapplications and Potential Toxicity 361
14 Nanostructured Hydrogels for Diabetic Management 387
15 Inorganic Nanomaterials for Bone Tissue Engineering 421
16 Nanotechnology in Coronary Artery Stent Coating 437

The book discusses in a detailed manner various nanomaterials used for biomedical applications, including clinical applications, diagnosis and tissue engineering. After the presentation of an overview of biomedical nanomaterials, including their classification and applications, the first part of the book is devoted to biomedical nanomaterials for therapy applications. For example, polymer micelles, dendrimers, polymer-drug conjugates as well as antibody-drug conjugates are discussed with respect to their cancer drug delivery properties. The next parts discuss biomedical nanomaterials that are used for imaging, diagnosis and sensors, as well as for tissue engineering. In the final section, the safety of biomedical nanomaterials is elaborated.

Authors
• Yuliang Zhao is Professor in Chemistry and Physics. He moved to Chinese Academy of Sciences from RIKEN, Japan, as a Hundred Elite Professor in 2001. His research is mainly focused on the biomedical effects of nanostructures and nanoscale materials, including the biomedical functions of nanomaterials, the toxicological effects of nanomaterials and establishing standard procedures for safety assessment of nanoproducts, surface chemistry of nanoparticles and their novel properties, and molecular dynamics using theoretical simulation of the dynamic processes of the interplay between nanosystems and biosystems.
• Youqing Shen is the Director of Center for Bionanoengineering, Department of Chemical and Biological Engineering, Zhejiang University at Hangzhou, China. After obtaining his doctor of science degree from Zhejiang University and his PhD from McMaster University, Canada, he was appointed as an assistant professor and then early promoted to tenured associate professor of the University of Wyoming, USA. His research focuses on polymer bionanomaterials for biodelivery as well as for cancer chemotherapy and imaging. He has authored more than 150 scientific publications and one book.