BRAIN NEUROTRAUMA. MOLECULAR, NEUROPSYCHOLOGICAL AND REHABILITATION ASPECTS

Features
- Features content written by top experts in the areas of CNS injury, rehabilitation and biomarker research
- Includes coverage of current biomarker identification and assessment in several clinical and experimental brain injury disorders
- Discusses different neurotherapeutic strategies along with current diagnostic and prognostic tools utilized in neurotrauma
- Presents an "omics" overview of different platforms (microRNA, neuroproteomics, genomics and neurosystems biology that have been applied to study brain injury mechanisms and pathways)
- Describes current experimental models used for blast, spinal cord, and traumatic brain injury
- Expands beyond the lab work experience and provides guidance on translating experimental results into the clinic

Summary
Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research.
The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries.
Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Authors
- Firas Hosni Kobeissy is an assistant professor in the Department of Psychiatry of the University of Florida McKnight Brain Institute and serves as the associate scientific director of the Center for Neuroproteomics and Biomarkers Research. He earned his PhD from the University of Florida and has published in the field of brain injury biomarkers, neuroproteomics, and neurosystems biology. Dr. Kobeissy’s current research overlaps the fields of neuroscience and psychiatry with a focus on drug abuse neurotoxicity and traumatic brain injury neuroproteomics. He has published more than 70 peer-reviewed papers, reviews, and book chapters as well as co-edited three books. He has also co-authored five U.S. patents. Dr. Kobeissy serves as an editorial member on several journals related to proteomics, neuroscience, and brain injury and has been a member on several study sections of brain injury and stroke.
- Stuart W. Hoffman is the scientific program manager of the brain injury portfolio in the rehabilitation research and development service at the U.S. Department of Veteran Affairs (VA) The portfolio is focused on promoting translational research that improves outcomes in veterans living with the chronic effects of stroke, traumatic brain injury, and its co-morbidities. He also represents VA/ORD on TBI research. In this role, he is the co-chair of the government steering committee for the VA/DoD Chronic Effects of Neurotrauma Consortium, as well as a member of several advisory boards for VA research centers, and serves on the congressionally mandated Traumatic Brain Injury Advisory Committee for the Veterans Health Administration. He received his doctoral degree in behavioral and molecular neuroscience at Rutgers University.

Table of Contents
Experimental CNS Trauma: A General Overview of Neurotrauma Research;
Combat TBI: History, Epidemiology and Injury Modes
NEUROMECHANISMS IN BRAIN INJURY
Development of Concepts in the Pathology of Traumatic Axonal and Traumatic Brain Injury
Pathophysiology of Mild TBI: Implications for Altered Signaling Pathways
Oxidative Stress, Brain-Edema, Blood-Brain Barrier Permeability and Autonomic Dysfunction from Traumatic Brain Injury
The Contributing Role of Lipid Peroxidation and Protein Oxidation in the Course of CNS Injury Neurodegeneration and Neuroprotection: An Overview
IGF-1/IGF-R Signaling in Traumatic Brain Injury: Impact on Cell Survival, Neurogenesis, and Behavioral Outcome
Microglia in Experimental Brain Injury: Implications on Neuronal Injury and Circuit Remodeling
Evaluating the Effects of APOE4 after Mild Traumatic Brain Injury in Experimental Models
The Cytoprotective role of Prostaglandin D2 DP1 Receptor Against Neuronal Injury Following Acute Excitotoxicity and Cerebral Ischemia
MANAGEMENT IN CNS TRAUMA
Chronic Pain in Neurotrauma: Implications on Spinal Cord and Traumatic Brain Injury
Nonconvulsive Seizures as Secondary Insults in Experimental Traumatic Brain Injury
Characterization and Management of Headache after Mild Traumatic Brain Injury
Traumatic Brain Injury (TBI)-Induced Spasticity: Neurobiology, Treatment, and Rehabilitation
MODELING BRAIN INJURY
Techniques and Methods of Animal Brain Surgery: Perfusion, Brain Removal, and Histological Techniques
Controlled Cortical Impact Model
A Two-Model Approach to Investigate the Mechanisms Underlying Blast-Induced Traumatic Brain Injury
Acute Pathophysiology of Blast Injury: From Biomechanics to Experiments and Computations: Implications on Head and Polytrauma
Modeling Fluid Percussion Injury: Relevance to Human Traumatic Brain Injury
IMAGING AND BIOMARKERS
CNS Trauma Biomarkers and Surrogate Endpoints Pipeline from Bench to Bedside: A Translational Perspective
The Use and Potential of pNF-H as a General Blood Biomarker of Axonal Loss: An Immediate Application for CNS Injury
Exploring Serum Biomarkers for Mild Traumatic Brain Injury
Modeling the Neurobehavioral Consequences of Blast-Induced Traumatic Brain Injury Spectrum Disorder and Identifying Related Biomarkers
Magnetic Resonance Imaging Application in the Area of Mild and Acute Traumatic Brain Injury: Implication for Diagnostic Marker
Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with ex Vivo NMR Spectroscopy-Based Metabolite Quantification
The Emerging Impact of microRNAs in Neurotrauma Pathophysiology and Therapy
Neuroproteome Dynamics in Modeled Brain Injury: A Systems Neurobiology Perspective
Gene Interaction Hierarchy Analysis can be an Effective Tool for Managing Big Data Related to Unilateral Traumatic Brain Injury
Autoantibodies in CNS Trauma and Neuropsychiatric Disorders: A New Generation of Biomarkers
Systems Biology Application to Decipher Mechanisms and Novel Biomarkers in CNS Trauma
NEUROCOGNITIVE AND NEUROBEHAVIORAL TOPICS IN BRAIN INJURY
Neuropathology of Mild Traumatic Brain Injury: Correlation to Neurocognitive and Neurobehavioral Findings
Blast-Related Mild Traumatic Brain Injury: Neuropsychological Evaluation and Findings
Persistent Cognitive Deficits: Implications of Altered Dopamine in Traumatic Brain Injury
NEUROREHABILITATION AND NEUROPROTECTION
Rehabilitative Paradigms after Experimental Brain Injury: Relevance to Human Neurotrauma
Models of Posttraumatic Brain Injury Neurorehabilitation
Translational Considerations for Behavioral Impairment and Rehabilitation Strategies after Diffuse Traumatic Brain Injury
Endothelin, Cerebral Blood Flow, and Traumatic Brain Injury: Implications for a Future Therapeutic Target
Application of Novel Therapeutic Agents for CNS Injury: NAAG Peptidase Inhibitors
Neuregulin-1 and Neurovascular Protection
Potential Use of Calpain Inhibitors as Brain Injury Therapy
Nanoparticles for Neurotherapeutic Drug Delivery in Neurodegenerative Disorders: Application in Neurotrauma
Stem Cell Therapy in Brain Trauma: Implications for Repair and Regeneration of Injured Brain in Experimental TBI Models
Cortical Stimulation-Induced Structural Plasticity and Functional Recovery after Brain Damage
Cranial Nerve Noninvasive Neuromodulation: New Approach to Neurorehabilitation
MILD BRAIN INJURY AND SPORT CONCUSSION
Blast Injuries and Blast-Induced Neurotrauma Overview of Pathophysiology and Experimental Knowledge: Models and Findings
Animal Models for Concussion: Molecular and Cognitive Assessments—Relevance to Sport and Military Concussions
The Problem of Neurodegeneration in Cumulative Sports Concussions: Emphasis on
Neurofibrillary Tangle Formation
SUBSTANCE ABUSE AND COMORBID CONDITIONS
Evidence for Beneficial and Adverse Effects of Alcohol in Animal Models and Clinical Studies of Traumatic Brain Injury
Modeling TBI-Induced Alterations in Alcohol Use Behaviors
Index