BREAST CANCER. INNOVATIONS IN RESEARCH AND MANAGEMENT

1. Targeting PI3K/AKT/mTOR Pathway
2. Targeting the CDK4/6 Pathway in Breast Cancer
3. Fundamental Pathways in Breast Cancer 1: Signaling from the Membrane
4. Fundamental Pathways in Breast Cancer 2: Maintenance of Genomic Stability
5. Fundamental Pathways in Breast Cancer 3: Estrogen Biology
6. Fundamental Pathways in Breast Cancer 4: Signaling to Chromatin in Breast Development
7. Mouse Models of Breast Cancer: Deceptions that Reveal the Truth
8. Epidemiology, Lifestyle, and Environmental Factors
9. Chemoprevention
10. Surgical Prevention
11. Premalignant and Pre-invasive Lesions of the Breast
12. Prognostic and Predictive Role of Genetic Signatures
13. Special Types of Breast Cancer and Non-epithelial Tumors
14. Pathology After Neoadjuvant Treatments
15. Breast Cancer Genomics
16. The Pathology Report
17. Radiological Screening of Breast Cancer: Evolution
18. Innovation in Breast Cancer Radiology
19. Nuclear Medicine in the Clinical Management (ROLL, SNB, and PET)
20. One-Step Systemic Staging for Patients with Breast Cancer
21. Imaging Findings After Surgery
22. Integrated Breast Biopsy for Best Radiological Diagnosis of Breast Cancer
23. Conservative Surgery
24. The Conservative Mastectomy
25. Surgical Treatment of Local Recurrence in Breast Cancer Patients
26. Management of the Axilla
27. Management of Intraepithelial Disease
28. Breast-Conserving Surgery After Neoadjuvant Therapy
29. Surgical Treatment of the Primary Tumor in Patients with Metastatic Breast Cancer (Stage IV Disease)
30. Breast Cancer in Lymphoma Survivors
31. Surgery of Metastases in Stage IV Breast Cancer
32. Breast Reconstruction with Tissue Expander and Definitive Implant Replacement
33. The Pedicled TRAM Flap in Breast Reconstruction
34. Contralateral Breast Management
35. Lipofilling
36. Breast Reconstruction with Biological and Non-biological Meshes and Matrices
37. How to Manage Complications in Breast Reconstruction
38. Adjuvant Systemic Therapies by Subtypes: Guidelines
39. Primary Systemic Therapies: Guidelines
40. Treatment of Advanced Disease: Guidelines
41. Endocrine Therapies in the Adjuvant and Advanced Disease Settings
42. Chemotherapy Regimens in the Adjuvant and Advanced Disease Settings
43. Anti-HER2 Therapies in the Adjuvant and Advanced Disease Settings
44. Adjuvant Treatment with Bone-Targeting Agents (Bisphosphonates and Anti-RANK-Ligand Antibody)
45. Systemic Treatment for Specific Medical Situations
46. Conceptual Basis and Principles of Radiation Oncology
47. Whole-Breast Irradiation Following Breast-Conserving Surgery for Invasive Breast Cancer
48. Whole-Breast Radiation Following Breast-Conserving Surgery in Noninvasive Cancer
49. Postmastectomy Radiation Therapy of Early Breast Cancer
50. Accelerated Partial Breast Irradiation
51. Radiotherapy for Metastatic Lesions
52. Emergencies in Breast Cancer
53. Breast Cancer (Diagnosed) During Pregnancy: Adapting Recent Advances in Breast Cancer Care for Pregnant Patients
54. Chest Wall Disease: The Clinical Continuum Between Inflammatory and Lymphangitic Breast Cancer
55. Male Breast Cancer
56. Treatment of Central Nervous System Involvement
57. Follow-Up of Patients with Breast Cancer
58. Targeting Immune Checkpoint
59. Targeting Genome Instability and DNA Repair
60. Targeting FGFR Pathway in Breast Cancer
61. Integrating Next-Generation Sequencing Data in Trial Design
62. Lifestyle and Breast Cancer
63. Psychological Support in Breast Cancer Patients: A Personalized Approach
64. HIFU and Radio Frequency as Alternatives to Surgery
65. Hyperthermia with Radiotherapy and with Systemic Therapies
66. Circulating miRNA in Early Diagnosis
67. Relevance of Stem Cells
68. Subgroup Analyses and Information from Clinical Trials on Breast Cancer
69. The Methodology of Meta-Analyses and Its Potential Contribution to Patient Care
70. Trial Designs and Biostatistics for Molecular-Targeted Agents
71. Bioinformatics for Clinical Use in Breast Cancer

This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.

Features
• Describes all the important recent advances in the management of breast cancer
• Covers progress in understanding of genetics and biology in detail
• Designed to serve as a state-of-the-art reference for practitioners, residents, researchers, and advanced students

Authors
• Umberto Veronesi is Scientific Director Emeritus of the European Institute of Oncology (EIO), Milan, Italy, which he founded in 1994. He was Minister of Health in the Italian Government from 2000 to 2001, and from 2008 to 2011 was a senator of the Italian Republic. Prof. Veronesi has devoted the greater part of his professional career to exploring new pathways of research with the aim of improving the treatment and quality of life of cancer patients, and he is responsible for a range of key innovations. He has also initiated educational enterprises for the training of oncologists, as founder of both the European School of Oncology and The European Society of Surgical Oncology. He has served as President of the International Union Against Cancer, of the European Organization for Research and Treatment of Cancer, and of the Federation of European Cancer Societies. He has been awarded 14 honorary degrees and is recipient of many honors and prizes, including the Gold Medal of the Italian Health Ministry. He is the author of more than 800 scientific publications and 12 oncological treatises.
• Aron Goldhirsch is Deputy Scientific Director at the European Institute of Oncology, Milan, Italy. He has served as Co-Chairman of the Scientific Committee of the International Breast Cancer Study Group (IBCSG; formerly the Ludwig Group) and co-founder of the Breast International consortium (BIG). Since 1992 has been Professor for Medical Oncology at the University of Bern, Switzerland. Dr. Goldhirsch has received various international prizes and honors, including the prestigious St. Gallen International Breast Cancer Award (2013), the American Society of Clinical Oncology’s Gianni Bonadonna Breast Cancer Award (2014), and the Komen Brinker Award for Scientific Distinction (co-recipient with Prof. Richard Gelber in 2008). He is the author of over 700 peer-reviewed articles and chapters in reference books, editor or co-editor of ten books, and he serves on the editorial board of several oncology and breast cancer research journals.
• Paolo Veronesi is Associate Professor of General Surgery at the University of Milan School of Medicine, and Director of the Breast Surgery Division at the European Institute of Oncology, Milan, Italy. He was deeply involved in the development of breast-conserving surgery and, more recently, in the development of the sentinel lymph node biopsy technique, intraoperative radiotherapy, and conservative mastectomy. Dr. Veronesi was President of the XXXIII Congress of the Italian Society of Surgical Oncology in June 2010. He has been President of the Umberto Veronesi Foundation for the progress of the science since 2005. He is the author of more than 240 papers and 25 book chapters, mainly in the field of breast diseases.
• Maria Cristina Leonardi has worked at the Division of Radiation Therapy at the European Institute of Oncology, Milan, Italy since 1997; in 2009 she beca me Deputy Director of the Division, having previously been Senior Assistant. Her main activities include 3D radiotherapy, intraoperative radiotherapy, intensity modulated radiotherapy and image-guided radiotherapy and she has been involved in numerous clinical studies involving breast and rectal cancer. Dr. Leonardi graduated in Medicine from the University of Milan in 1992 and subsequently completed her specialization in Radiation Oncology in 1996 at the Istituto Nazionale Tumori, Milan. She is a Member of the Italian Radiation Oncologists (AIRO) Breast Cancer Group and co-author of the Italian Guidelines on Breast Cancer. Currently, she is the national coordinator of the AIRO Working Group on Intraoperative Radiotherapy.
• Oreste D. Gentilini was born in 1968. After 15 years at the European Institute of Oncology is now Head of Breast Surgery and Director of the Breast Unit at the San Raffaele University and Research Hospital, Milano. His interest and research commitments have focused on sentinel lymph node biopsy, breast cancer in young women, breast cancer during pregnancy and the possibility of extending the fields of breast conservation in special clinical scenarios. Dr. Gentilini is Chairman of the SOUND (Sentinel node vs Observation after axillary Ultra-souND) prospective, randomized, multicentre, international trial and author of more than 100 papers.