• Chapter 1: Anatomic Considerations and Examination of Cardiovascular Specimens (Excluding Devices)
Abstract
Gross Examination of the Heart
Examination of Surgical Cardiovascular Specimens
Microscopic Examination of the Blood Vessels and Heart
• Chapter 2: Age-related Cardiovascular Changes and Diseases
Abstract
Nonspecific Cardiovascular Changes of Aging
Changes in the Conduction System
Changes in Arteries
Age-related Diseases
Disorders of Premature Aging
Telomere
• Chapter 3: Vascular Pathobiology: Atherosclerosis and Large Vessel Disease
Abstract
Introduction to Atherosclerosis
Epidemiology and Risk Factors
Gross and Microscopic Morphology of the Fibroinflammatory Lipid Plaque
Steps in Atherosclerotic Plaque Formation and Complications
Cellular Function and Pathways in Atherogenesis
Nonatherosclerotic Diseases of the Aorta
• Chapter 4: Diseases of Small and Medium-sized Blood Vessels
Abstract
Introduction
Vascular Activation and Common Vascular Pathologic Changes
Congenital Vascular Diseases
Genetic Vascular Disorders
Endocrine/Metabolic Vascular Disorders
Vasculitis
Infection
Toxic Vasculopathies
Coagulopathic Disorders
Hypertension
Vascular Deposition Disorders
Intimal Proliferative Diseases
Arterial Dissections
Miscellaneous Conditions
Disorders of Veins
• Chapter 5: Aneurysms of the Aorta: Ascending, Thoracic and Abdominal and Their Management
Abstract
Introduction
Normal Anatomy and Histology of the Aorta
Aging Changes of the Aorta
Thoracic Aortic Aneurysms
Etiology and Pathologic Findings
Clinical Presentation and Natural History
Abdominal Aortic Aneurysm
Aortic Dissection
Management
• Chapter 6: Fundamental Principles in Cardiovascular Genetics
Abstract
Genetic Variation
Modern Molecular Diagnostics
Identifying the Genetic Basis of Cardiovascular Disease
Representative Genetic Cardiovascular Conditions
Molecular Diagnostics in Cardiovascular Pathology Practice
• Chapter 7: Myocardial Ischemia and Its Complications
Abstract
Definition and History
Clinical Manifestations
Epidemiology
Biochemical Changes with Ischemia and Biochemical Markers
Ultrastructural Evolution of Acute Ischemic Injury
Cellular and Subcellular Mechanisms of Myocardial Injury
Microscopic Evolution of Acute Ischemic Injury
Morphology of Coronary Arteries and Plaques
Tako-Tsubo Cardiomyopathy
Gross Evolution of Acute Ischemic Injury
Patterns of MI
Phenomena Associated with Ischemic Injury
Reperfusion of Ischemic Myocardium
Complications of MI
Recognition and Quantification of Acute Ischemic Injury
Pathology of Interventions
Pathophysiological and Pharmacological Interventions
Molecular Biology of Myocardial Ischemia
• Chapter 8: Pathophysiology of Heart Failure and an Overview of Therapies
Abstract
Overview of Heart Failure
Pathophysiology of HF
Neurohormonal Alterations in HF
Signaling Responses to Various Stimuli During HF
HF-related Alterations in Cellular Function and Biochemical Pathways
Metabolic Remodeling in HF
Summary of HF
Therapeutic Management of HF
• Chapter 9: Myocarditis
Abstract
Definition of Myocarditis
Diagnosis of Myocarditis
Histopathologic Patterns of Myocarditis
Etiologies of Myocarditis
Treatment of Myocarditis
• Chapter 10: Pathology of Sudden Death, Cardiac Arrhythmias and Conduction System
Abstract
Acknowledgments
Sudden Death
Cardiac Conduction System
Atrial Fibrillation
Appendix Guidelines for Postmortem Study of Sudden Death
• Chapter 11: Cardiomyopathies
Abstract
Definition and Classification of Cardiomyopathies
Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Arrhythmogenic Cardiomyopathy
Restrictive Cardiomyopathy
Others
• Chapter 12: Valvular Heart Disease
Abstract
Introduction
Functional Anatomy
Types of Valvular Dysfunction
• Chapter 13: Cardiac Valve Replacement and Related Interventions
Abstract
General Considerations
Valve-related Complications: Clinical Importance, Morphology, Secondary Effects, and Pathogenesis
Other Tissue Valve Substitutes
Catheter-based Valve Implantation
Valve Repair and Valve Sparing Procedures
New Developments and Future Considerations
Pathologic Considerations in Analysis of Heart Valve Substitutes
Disclosure
Appendix
• Chapter 14: The Pathology of Cardiovascular Interventions and Devices for Coronary Artery Disease, Vascular Disease, Heart Failure, and Arrhythmias
Abstract
Endovascular Therapies and Myocardial Revascularization
Aortic and Peripheral Vascular Replacement and Reconstruction
Cardiac Assist and Replacement
Arrhythmia Control
• Chapter 15: Congenital Heart Disease: Pathology, Natural History, and Interventions
Abstract
Introduction
Epidemiology and Etiology
Embryology of the Cardiovascular System
Clinical Features and Consequences
Specific Forms of CHD
Surgical and Nonsurgical Interventions for Treatment of CHD
CHD in the Adult
Natural History of CHD Without and with Interventions
• Chapter 16: The Pericardium and Its Diseases
Abstract
Anatomy
Physiology
Histology
Echocardiography
Pericardiocentesis and Biopsy
Congenital Abnormalities
Pericardial Effusion After Cardiac Surgery
Pneumopericardium
Early Postmyocardial Infarction Pericarditis and Dressler Syndrome
Iatrogenic and Traumatic Pericarditis
• Chapter 17: Pathology of Cardiac Transplantation
Abstract
General Clinicopathologic Considerations
Pathology of the Explanted Recipient Heart
Pathology of the Donor Heart
Pathology of the Allograft
Heart Transplantation in Combination with Other Organs
Pathological Review of an EMB
Approach to the Examination of a Failed Allograft
Future Considerations
• Chapter 18: Toxins and the Heart
Abstract
Introduction
Endocardium
Myocardium
Pericarditis
Primary Conduction System Abnormalities
Coronary Artery Lesions
Cocaine-Other Drug Interactions
Drugs to Treat Attention Deficit-Hyperactivity Disorders
Antipsychotic Medications
Nonsteroidal Anti-inflammatory Drugs
Myocardial Toxins as a Cause of Death
• Chapter 19: Tumors of the Cardiovascular System: Heart and Blood Vessels
Abstract
Incidence and Classification
Clinical Symptoms
Reactive Cardiac Masses and Pseudotumors
Ectopias
Hamartomas and Benign Neoplasms
Hamartomas of Cardiac Muscle
Benign Fatty Tumors
Benign Tumors of Myofibroblastic Tissue
Miscellaneous Benign Fibrous Tumors
Cardiac Myxoma
Benign Neural Neoplasms
Malignant Tumors
Metastatic Tumors
Sarcomas of the Great Vessels
• Chapter 20: Forensic Aspects of Cardiovascular Pathology
Abstract
Investigative Information
General Changes
Primary Diseases/Injuries of the Heart
Cardiomyopathies, Myocarditis, and Genetic Causes of SCD
Anomalies and Diseases of the Aorta and Coronary Arteries
Diseases of the Cardiac Valves
Ancillary Studies
Sudden Death Following Surgery and Medical Procedures
Organ and Tissue Harvesting
Cardiovascular Pathology Consultation
Summary
• Index
• Serves as a contemporary, all-inclusive guide to cardiovascular pathology for clinicians and researchers, as well as clinical residents and fellows of pathology, cardiology, cardiac surgery, and internal medicine
• Offers new organization of each chapter to enable uniformity for learning and reference: Definition, Epidemiology, Clinical Presentation, Pathogenesis/Genetics, Light and Electron Microscopy/Immunohistochemistry, Differential Diagnosis, Treatment and Potential Complications
• Features six new chapters and expanded coverage of the normal heart and blood vessels, cardiovascular devices, congenital heart disease, tropical and infectious cardiac disease, and forensic pathology of the cardiovascular system
• Contains 400+ full color illustrations and an online image collection facilitate research, study, and lecture slide creation
Authors
• L. Maximilian Buja, MD, The University of Texas Health Science Center at Houston, TX, USA; Houston Academy of Medicine Texas Medical Center Library, Houston, TX, USA.
• Jagdish Butany, Professor, University of Toronto & Director, Division of Pathology, Deptartment of Laboratory Medicine and Pathobiology, University Health Network / Laboratory Medicine Program Toronto General Hospital; Consultant Cardiovascular Pathologist/Director Autopsy Services, Toronto, Ontario, Canada
Table Of Contents:
• Chapter 1: Anatomic Considerations and Examination of Cardiovascular Specimens (Excluding Devices)
• Chapter 2: Age-related Cardiovascular Changes and Diseases
• Chapter 3: Vascular Pathobiology: Atherosclerosis and Large Vessel Disease
• Chapter 4: Diseases of Small and Medium-sized Blood Vessels
• Chapter 5: Aneurysms of the Aorta: Ascending, Thoracic and Abdominal and Their Management
• Chapter 6: Fundamental Principles in Cardiovascular Genetics
• Chapter 7: Myocardial Ischemia and Its Complications
• Chapter 8: Pathophysiology of Heart Failure and an Overview of Therapies
• Chapter 9: Myocarditis
• Chapter 10: Pathology of Sudden Death, Cardiac Arrhythmias and Conduction System
• Chapter 11: Cardiomyopathies
• Chapter 14: The Pathology of Cardiovascular Interventions and Devices for Coronary Artery Disease, Vascular Disease, Heart Failure, and Arrhythmias
• Chapter 15: Congenital Heart Disease: Pathology, Natural History, and Interventions
• Chapter 16: The Pericardium and Its Diseases
• Chapter 17: Pathology of Cardiac Transplantation
• Chapter 18: Toxins and the Heart
• Chapter 19: Tumors of the Cardiovascular System: Heart and Blood Vessels
• Chapter 20: Forensic Aspects of Cardiovascular Pathology
• Index
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