CAVERNOMAS OF THE CNS. BASIC SCIENCE TO CLINICAL PRACTICE

•Brief History of Cavernous Malformations
•Definition and structure of cerebral cavernous malformations
•Molecular Biology of CCM
•Presentation
• Neuroimaging of Cerebral Cavernous Malformations
•Natural history of cavernous malformations
•Hemispherical Cavernomas in non-eloquent and eloquent areas
•Cavernoma-Related Epilepsy
•Surgery of deep-seated cavernous malformations
•Surgery of brainstem and cerebellar cavernous malformations
•Stereotactic Radiosurgery of Cavernous Malformations
•Cavernomas in children
•Cavernomas During Pregnancy
•Spinal cavernous malformations
•Intraorbital cavernous malformations.

This book presents a complete up-to date description of cavernoma disease together with its known biology, genetics and variable clinical presentation. It facilitates improved decision-making on surgical intervention by presenting different cases, highlighting the particular features of lesions such as anatomical location, eloquences of adjacent brain and type of presentation that are important when making decisions. In addition, the reader is brought up to speed with developments in the neuroimaging and active treatment techniques, especially surgical resection and radiosurgery. Finally, the natural history of the disease is taken into account and compared to the possible benefits of surgical treatment. Cavernomas of the CNS: Basic Science to Clinical Practice provides a comprehensive overview from the fundamentals of this condition, to special patient groups such as children and pregnant women. Therefore, it is an indispensable resource for neurovascular surgeons, neurosurgical residents and neurologists.

Features
• Improves the reader’s understanding of all nuances of pathology under consideration though authors’ own graphic documentnation on all aspects of cavernomas
• Introduces the authors key guiding principles, including their philosophy of treatment decision
• Presents case studies helping to understand what is really achievable in cavernoma treatment
• Provides thorough discussion of particular cases – helps understanding of decision making in cavernoma treatment

Authors
• Vladimír Beneš, MD, PhD
Professor Benes was EANS Vice President 2003-2007, Chairman of the Training Committee 2007–2011 and EANS President 2011–2015. He was President of European Skull Base Surgery Society 2007-2009. Currently he is a member of AANS, CNS, German Academy of Neurosurgery, World Academy of Neurosurgery and takes part in editorial boards of various respected journals such as Pain, Acta Neurochirurgica, World Neurosurgery, etc.
• Ondrej Bradác, MD, MSc, PhD.
Ondrej Bradac has been the Assitant to Professor Benes since 2006 working on topics in cerebrovascular diseases. He spent a study year at Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, UK. He was an investigator of international studies STICH II and NEWTON. Ondrej Bradac has published 59 papers with 647 citations according to SCOPUS. Together with Vladimir Benes he was editor of Brain AVM book published by Springer in 2017. He is a member of Czech Neurosurgical Society, EANS and AANS.