1. Historical Perspective and Current Focus
2. Most Recent Clinical Advances in CAR T Cell and Gene Therapy 2017/2018
3. Chimeric Antigen Receptor T Cells: Antigen Selection, CAR Development, and Data in Neoplastic Hematology
4. Chimeric Antigen Receptor T Cells for Leukemias in Children: Methods, Data, and Challenges
5. Chimeric Antigen Receptor-T Cells for Leukemias in Adults: Methods, Data and Challenges
6. Chimeric Antigen Receptor T Cells for Lymphomas: Methods, Data, and Challenges
7. T Cell Receptors-Gene-Modified T Cells for Cancer: Methods, Data, and Challenges
8. Cytotoxic T Cells for Infections: From Donor Specific to “Off the Shelf”
9. Regulatory T Cells: Broadening Applicability
10. Natural Killer Cells: What Have We Learned?
11. Dendritic Cells in Hematopoietic Cell Transplantation
12. Mesenchymal Stem Cells: From Bench to Bedside and Back
13. Gene Therapy for Neoplastic Hematology in Transplant Setting
14. Gene Therapy for Nonmalignant Hematology
In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee.