CELLULAR SIGNAL PROCESSING: AN INTRODUCTION TO THE MOLECULAR MECHANISMS OF SIGNAL TRANSDUCTION

1. The "Brain of the Cell": Data Processing by Protein Networks
2. Supplying the Network with Energy: Basic Biochemistry of Signal Transduction
3. Evolution of Cellular Data Processing
4. Basic Equipment: G-Proteins, Second Messengers, and Protein Kinases
5. Signal Transduction by Receptors with Seven Transmembrane Domains
6. Signal Transduction by Serine/Threonine Kinase-Coupled Receptors
7. Signal Transduction by Tyrosine Kinase- and Protein Phosphatase Coupled Receptors
8. Eukaryotic Gene Transcription: The Ultimate Target of Signal Transduction
9. Signals Controlling mRNA Translation
10. Signal Transduction by Small G-Proteins: The Art of Molecular Targeting
11. Mitogen-activated Protein Kinase and Nuclear Factor ?B Modules
12. Regulation of Cell Division
13. Signal Transduction by Proteolysis, and Programmed Cell Death
14. Signal Transduction by Ions
15. Sensory Signal Processing
16. Signaling at Synapses: Neurotransmitters and their Receptors
17. Putting Together the Pieces: The Approach of Systems Biology

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.

Features
• The second edition includes expanded coverage of prokaryotes, as well as new content on developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling. There is also new coverage of intrinsically disordered proteins, inflammasomes, regulated necrosis, autophagy, and optogenetics
• As with the first edition, the text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. Keeping the same structure provides familiar readers with a seamless rollover transition. New and revised figures, concepts, and methods provide instructors with the most up-to-date research and investigations possible
• New section summaries now appear throughout each chapter as concise recaps of important ideas
• Completely updated literature is listed in end-of-chapter “Further Reading,” now organized by chapter sections
• The book provides a comprehensive foundation for advanced students and researchers across multiple disciplines: biology, biochemistry, bioinformatics, systems biology, pharmacology, and medical school