CELLULAR THERAPY FOR NEUROLOGICAL INJURY

• Acute Neurological Injury: Pathophysiology as Related to Therapeutic Targets
Charles S. Cox, Jr., Benjamin Aertker, and George P. Liao
• Oligodendrocyte Precursor Cells in Spinal Cord Injury Repair
Qi Lin Cao
• Cell-Based Therapy for Stroke
Vivek Misra, Bing Yang, Sushil Sharma, and Sean I. Savitz
• Experimental Models of Traumatic Brain Injury: Clinical Relevance and Shortcomings
Edward W. Vogel III, Barclay Morrison III, Megan N. Evilsizor, Daniel R. Griffiths, Theresa C. Thomas, Jonathan Lifshitz, Richard L. Sutton, Joseph B. Long, David Ritzel, Geoffrey S.F. Ling, James Huh, Ramesh Raghupathi, and Tracy K. McIntosh
• Behavioral Testing after Experimental Traumatic Brain Injury
Bridgette D. Semple and Linda J. Noble-Haeusslein
• Translation Biomarkers for Traumatic Brain Injury
Pramod K. Dash, Michael Hylin, and Anthony N. Moore
• Neuro-Immune Signaling Circuit in Traumatic Brain Injury
Scott D. Olson
• Soluble Factors and Mechanisms of Action of Mesenchymal Stem Cells in Traumatic Brain Injury and Organ Injury Induced by Trauma
Shibani Pati and Stuart L. Gibb
• Use of a Natural Modulator of Inflammation (TSG-6) for the Therapy of Traumatic Brain Injury
Darwin J. Prockop
• Tissue Engineering and Cell-Based Therapeutics for Repair of Myelomeningocele
KuoJen Tsao and Luke R. Putnam

Cellular Therapy for Neurological Injury discusses the current status of cellular therapy for neurological disorders. The primary areas of focus include traumatic brain injury, stroke (ischemic and hemorrhagic), and spinal cord injury. The book explores cell therapy approaches to these and other conditions, while discussing current advances and a literature review in the context of a field that is moving rapidly.
The book presents a translational focus, addressing barriers and opportunities to moving forward. The mechanisms of injury are explored, as well as how these mechanisms influence the type of cell therapy used, the route of delivery, and dosing regimen. Written by leaders in the field, this is an invaluable resource for clinicians and researchers alike.

Features
• Reviews strategies for cellular approaches to neurological injuries
• Provides a comprehensive analysis of the mechanisms of action of cell therapies in diverse neurological disorders
• Presents guidelines for assessing and treating Traumatic Brain Injury (TBI)
• Provides forward-looking views into novel therapeutic approaches for spinal cord injury, stroke, and TBI
• Contributing authors are leading researchers in a rapidly expanding field

Author
Charles S. Cox, Jr., MD, University of Texas, Houston, USA