CHORDOMAS: TECHNOLOGIES, TECHNIQUES, AND TREATMENT STRATEGIES

• Section I: Definition, History, Demographics, Pathology, and Pathogenesis
Chapter 1: Historical Aspects
Chapter 2: The Descriptive Epidemiology of Chordomas
Chapter 3: Evolutionary Origin of the Notochord
Chapter 4: Molecular Biology of Chordomas
Chapter 5: Cytogenics of Chordomas
Chapter 6: Local Invasion and Metastasis
Chapter 7: Pathology
Chapter 8: Experimental Models of Chordomas
• Section II: Diagnosis of Chordomas
Chapter 9: Radiologic Findings and Differential Diagnosis of Chordomas at the Skull Base
Chapter 10:Radiologic Findings and Differential Diagnosis of Chordomas in the Spine
Chapter 11:Molecular Imaging of Chordomas
• Section III: Surgical Treatment of Chordomas
Chapter 12: Surgical Decision Making in Chordomas
Chapter 13: Choice of the Optimal Surgical Approach for Skull Base Chordomas
Chapter 14: Anterior Approaches to the Clivus
Chapter 15: Endoscopic Approaches for Skull Base Chordomas
Chapter 16: Frontobasal Approaches to Clivus Chordomas
Chapter 17: Cranio-orbital “Zygomatic Approach for Chordomas
Chapter 18: Epidural Middle Fossa Approaches
Chapter 19: The Extended Petrosal Middle Fossa Approach
Chapter 20: The Transcondylar Approach to the Clivus
Chapter 21: Craniovertebral Reconstruction after Chordoma Resection
Chapter 22: Surgery for Spinal Chordomas
Chapter 23: Intraoperative Assistive Technologies for Chordoma Surgery
• Section IV: Special Topics in Chordomas
Chapter 24: Chordomas: A Personal Perspective
Chapter 25: Radiation Treatment for Chordomas
Chapter 26: Charged Particle Beams in Management of Clival Chordomas
Chapter 27: Stereotactic Radiosurgery for Chordomas
Chapter 28: Recurrence in Skull Base Chordomas and Its Management
Chapter 29: Outcome and Quality of Life of Patients with Chordomas
Chapter 30: Chordomas and Chondrosarcomas in the Pediatric Population
Chapter 31: Future Prospects in the Treatment of Skull Base Chordomas

Written by an impressive cadre of internationally-renowned experts, this textbook is the most current, concise, and definitive resource on diagnosis and management of this complex pathology. The book starts with a historical overview, epidemiology, molecular pathogenesis, cytogenetics, local invasion and metastasis, and pathology. A thorough discussion covers diagnostic radiological and radionuclide imaging such as MRI, PET; SPECT, PET-CT, and PET-MRI, and clinical traits of skull base and spinal chordomas as defined by imaging modalities. Subsequent chapters explore decision making including selecting the most optimal techniques, surgical procedures, specialized topics, and new horizons in chordoma treatment.

Features
• This is the most current, concise, and definitive resource on diagnosing and treating Chordomas.
• Comprehensive coverage of treatment options including surgery, radiation and chemotherapy, by an excellent cast of international contributors.
• This edition addresses Proton Bean Therapy, which is the latest treatment option for Chordomas.

Authors
• M. Necmettin Pamir. Department of Biochemistry. Acibadem University. Kissimmee, Turkey
• Ossama Al-Mefty. Department of Neurosurgery. Brigham and Women's Hospital. Boston, Massachusetts, USA
• Luis A.B. Borba. Hospital Universitario Evangelico de Curitiba. Curitiba, Brazil