CHOROIDAL NEOVASCULARIZATION

• Section I: History
History of choroidal neovascularization (CNV) - initial understanding and development
• Section II: Basics
Pathogenesis – various proposed mechanisms
Histopathology – recent understanding in relationship with imaging
Electron microscopy – update in choroidal changes
• Section III: Clinical classification
Neovascular age-related macular degeneration (AMD) – clinical features, imaging, protocols and outcomes
CNV secondary to pathologic myopia – clinical features, imaging and treatment outcomes
Pachychoroid related CNV – recent updates, imaging and outcomes
Inflammatory CNV – clinical features, imaging and treatment outcomes
Dystrophy related CNV – clinical features, imaging and treatment outcomes
CNV secondary to angioid streaks – clinical features, imaging and treatment protocols
Idiopathic CNV – clinical features, imaging and treatment outcomes
CNV associated with idiopathic juxtafoveal telangiectasia – clinical features, imaging and treatment outcomes
CNV associated with other causes – laser induced, idiopathic intracranial hypertension, choroidal osteoma, trauma, choroidal coloboma, choroidal nevus, etc
Peripapillary CNVM – overview of various causes, imaging features and treatment outcomes
Pediatric CNVM – overview of various causes, imaging features and treatment outcomes
Polypoidal choroidal vasculopathy (PCV) – clinical features, imaging and treatment outcomes
• Section IV: Treatment options
Anti-VEGF current options – Ranibizumab, Bevacizumab, Aflibercept, Ziv-aflibercept, Conbercept
Photodynamic therapy – current status in anti-VEGF era
Surgical intervention – graft, retinal implant, the implantable miniature telescope, surgical removal of CNV, subretinal tissue plasminogen activator
• Section V: Clinical trials
n-AMD trials – comprehensive overview of PDT and anti-VEGF trials in AMD
Myopic CNV trials – comprehensive overview of PDT and anti-VEGF trials in AMD
Non-AMD CNV trials – comprehensive overview of various trials in non-AMD related CNV causes
PCV trials – comprehensive overview of PDT and anti-VEGF trials in PCV
• Section VI: Future directions
Stem cells in AMD – current status and future expectations
Newer molecules – newer targets in CNV and the upcoming research
Radiotherapy – role of radiotherapy and clinical trials
Other options – role of subthreshold laser, and other therapies in CNV
• Section VII: Rehabilitation
Low vision aids
Peripheral vision development – newer approach for macular diseases
Monitoring techniques – advanced home monitoring techniques and initial experience.

The book discusses all aspects of choroidal neovascularization (CNV), including the basics, clinical conditions associated with CNV, clinical trials related to CNV, future directions and rehabilitation. The first section covers the pathogenesis, proposed mechanisms, disease models, histopathology and electronmicroscopy. The next section explores CNV secondary to various clinical conditions, such as age-related macular degeneration (AMD), myopia, and less common conditions like choroidal osteoma. The book also covers clinical features, imaging characteristics, and treatment approaches, as well as clinical trials in CNV conditions with recent updates. Lastly, it features chapters on stem cell therapy, gene therapy, new molecules, and lasers, as well as a section on rehabilitation, which addresses home monitoring and low vision aids.This book is intended for retina specialists, retina fellows and general ophthalmologists.

Features
• Covers basics to clinical including future directions and rehabilitation
• Provides updated information on clinical trials on choroidal neovascularization
• Includes chapters on latest evidence-based approach in diagnosis and management of CNV

Author
Dr. Jay Chhablani is a Vitreo-Retina Specialist at the University of Pittsburgh Eye Center. He completed a clinical vitreo-retina fellowship at Sankara Nethralaya, Chennai, India, and was an International Council of Ophthalmology (ICO) fellow at Jules Gonin Eye Hospital, Switzerland, in 2009. He was a Clinical Instructor at the Jacobs Retina Center at Shiley Eye Center, University of California, San Diego, USA (2010 to 2012) before joining the faculty at L V Prasad Eye Institute, Hyderabad, India (2012-19). His areas of interest are macular disorders and recent imaging techniques. He has published more than 300 articles in peer-reviewed journals with a focus on the field of the choroid. He is the editor of the books Choroidal Disorders and Central Serous Chorioretinopathy, and he is on the review boards of all the high- impact ophthalmology journals. He is also on the editorial board of several specialty journals, including the American Journal of Ophthalmology. He is a member of the American Academy of Ophthalmology’s Global ONE network committee. He has won several national and international awards and delivered the inaugural Ian Constable lecture at the Asia-Pacific Vitreo-Retina Society in 2016. He received the Inaugural Namperumalsamy Young Researcher Award in 2018, presented by the Vitreo-Retina Society of India.