DEVELOPMENTAL BIOLOGY. 11TH EDITION

I. PATTERNS AND PROCESSES OF BECOMING: A FRAMEWORK FOR UNDERSTANDING ANIMAL DEVELOPMENT

1. Making New Bodies: Mechanisms of Developmental Organization
"How Are You?" The Questions of Developmental Biology
The Cycle of Life
An Example: A Frog's Life
Comparative Embryology
An Overview of Early Development
Keeping Track of Moving Cells: Fate Maps and Cell Lineages
Evolutionary Embryology
Medical Embryology and Teratology

2. Specifying Identity: Mechanisms of Developmental Patterning
Levels of Commitment
Autonomous Specification
Conditional Specification
Syncytial Specification
A Rainbow of Cell Identities

3. Differential Gene Expression: Mechanisms of Cell Differentiation
Defining Differential Gene Expression
Quick Primer on the Central Dogma
Evidence for Genomic Equivalence
Modulating Access to Genes
Anatomy of the Gene
The Gene Regulatory Network: Defining an Individual Cell
Mechanisms of Differential Gene Transcription
Differential RNA Processing
Control of Gene Expression at the Level of Translation
Posttranslational Regulation of Gene Expression
The Basic Tools of Developmental Genetics
Testing Gene Function

4. Cell-to-Cell Communication: Mechanisms of Morphogenesis
A Primer on Cell-to-Cell Communication
Adhesion and Sorting: Juxtacrine Signaling and the Physics of Morphogenesis
The Extracellular Matrix as a Source of Developmental Signals
The Epithelial-Mesenchymal Transition
Cell Signaling
Paracrine Factors: Inducer Molecules
The Cell Biology of Paracrine Signaling
Juxtacrine Signaling for Cell Identity

5. Stem Cells: Their Potential and Their Niches
The Stem Cell Concept
Stem Cell Regulation
Pluripotent Cells in the Embryo
Adult Stem Cell Niches
Adult Neural Stem Cell Niche of the V-SVZ
The Adult Intestinal Stem Cell Niche
Stem Cells Fueling the Diverse Cell Lineages in Adult Blood
The Mesenchymal Stem Cell: Supporting a Variety of Adult Tissues
The Human Model System to Study Development and Disease
Stem Cells: Hope or Hype?

II. GAMETOGENESIS AND FERTILIZATION: THE CIRCLE OF SEX

6. Sex Determination and Gametogenesis
Chromosomal Sex Determination
The Mammalian Pattern of Sex Determination
Primary Sex Determination in Mammals
Secondary Sex Determination in Mammals: Hormonal Regulation of the Sexual Phenotype
Chromosomal Sex Determination in Drosophila
Environmental Sex Determination
Mammalian Gametogenesis
Coda

7. Fertilization: Beginning a New Organism
Structure of the Gametes
External Fertilization in Sea Urchins
Activation of Egg Metabolism in Sea Urchins
Fusion of Genetic Material in Sea Urchins
Internal Fertilization in Mammals
Coda

III. EARLY DEVELOPMENT: CLEAVAGE, GASTRULATION, AND AXIS FORMATION

8. Rapid Specification in Snails and Nematodes
Developmental Patterns among the Metazoa
EARLY DEVELOPMENT IN SNAILS
Cleavage in Snail Embryos
Gastrulation in Snails
THE NEMATODE C. Elegans
Cleavage and Axis Formation in C. elegans
Gastrulation in C. elegans

9. The Genetics of Axis Specification in Drosophila
Early Drosophila Development
The Genetic Mechanisms Patterning the Drosophila Body
Segmentation and the Anterior-Posterior Body Plan
Segmentation Genes
The Homeotic Selector Genes
Generating the Dorsal-Ventral Axis
Axes and Organ Primordia: The Cartesian Coordinate Model
Coda

10. Sea Urchins and Tunicates: Deuterostome Invertebrates
Early Development in Sea Urchins
Sea Urchin Gastrulation
Early Development in Tunicates

11. Amphibians and Fish
EARLY AMPHIBIAN DEVELOPMENT
Fertilization, Cortical Rotation, and Cleavage
Amphibian Gastrulation
Progressive Determination of the Amphibian Axes
The Work of Hans Spemann and Hilde Mangold
Molecular Mechanisms of Amphibian Axis Formation
Regional Specificity of Neural Induction along the Anterior-Posterior Axis
Specifying the Left-Right Axis
EARLY ZEBRAFISH DEVELOPMENT
Cleavage
Gastrulation and Formation of the Germ Layers

12. Birds and Mammals
EARLY DEVELOPMENT IN BIRDS
Avian Cleavage
Gastrulation of the Avian Embryo
Axis Specification and the Avian "Organizer"
EARLY DEVELOPMENT IN MAMMALS
Cleavage
Mammalian Gastrulation
Mammalian Axis Formation
Twins
Coda

IV. BUILDING WITH ECTODERM: THE VERTEBRATE NERVOUS SYSTEM AND EPIDERMIS

13. Neural Tube Formation and Patterning
Transforming the Neural Plate into a Tube: The Birth of the Central Nervous System
Patterning the Central Nervous System
All Axes Come Together

14. Brain Growth
Neuroanatomy of the Developing Central Nervous System
Developmental Mechanisms Regulating Brain Growth
Development of the Human Brain

15. Neural Crest Cells and Axonic Specificity
THE NEURAL CREST
Regionalization of the Neural Crest
Neural Crest: Multipotent Stem Cells?
Specification of Neural Crest Cells
Neural Crest Cell Migration: Epithelial to Mesenchymal and Beyond
Migration Pathways of Trunk Neural Crest Cells
Cranial Neural Crest
The "Chase and Run" Model
Neural Crest-Derived Head Skeleton
Cardiac Neural Crest
ESTABLISHING AXONAL PATHWAYS IN THE NERVOUS SYSTEM
The Growth Cone: Driver and Engine of Axon Pathfinding
Axon Guidance
The Intrinsic Navigational Programming of Motor Neurons
How Did the Axon Cross the Road?
The Travels of Retinal Ganglion Axons
Target Selection: "Are We There Yet?"
Synapse Formation
A Program of Cell Death

16. Ectodermal Placodes and the Epidermis
CRANIAL PLACODES: THE SENSES OF OUR HEADS
The Dynamics of Optic Development: The Vertebrate Eye
Formation of the Eye Field: The Beginnings of the Retina
The Lens-Retina Induction Cascade
THE EPIDERMIS AND ITS CUTANEOUS APPENDAGES
Origin of the Epidermis
The Ectodermal Appendages
Coda

V. BUILDING WITH MESODERM AND ENDODERM: ORGANOGENESIS

17. Paraxial Mesoderm: The Somites and Their Derivatives
Cell Types of the Somite
Establishing the Paraxial Mesoderm and Cell Fates Along the Anterior-Posterior Axis
Somitogenesis
Sclerotome Development
Dermomyotome Development
Osteogenesis: The Development of Bones
Maturation of Muscle

18. Intermediate and Lateral Plate Mesoderm: Heart, Blood, and Kidneys
INTERMEDIATE MESODERM: THE KIDNEY
Specification of the Intermediate Mesoderm: Pax8 and Lim1
Reciprocal Interactions of Developing Kidney Tissues
LATERAL PLATE MESODERM: HEART AND CIRCULATORY SYSTEM
Heart Development
Blood Vessel Formation
Hematopoiesis: Stem Cells and Long-Lived Progenitor Cells
Coda

19. Development of the Tetrapod Limb
Limb Anatomy
Limb Bud
Hox Gene Specification of Limb Skeleton Identity
Determining What Kind of Limb to Form and Where to Put It
Outgrowth: Generating the Proximal-Distal Axis of the Limb
Specifying the Anterior-Posterior Axis
Generating the Dorsal-Ventral Axis
Cell Death and the Formation of Digits and Joints
Evolution by Altering Limb Signaling Centers

20. The Endoderm: Tubes and Organs for Digestion and Respiration
The Pharynx
The Digestive Tube and Its Derivatives
The Respiratory Tube

VI. POSTEMBRYONIC DEVELOPMENT

21. Metamorphosis: The Hormonal Reactivation of Development
Amphibian Metamorphosis
Metamorphosis in Insects
Metamorphosis of the Pluteus Larva

22. Regeneration
Many Ways to Rebuild
Hydra: Stem Cell-Mediated Regeneration, Morphallaxis, and Epimorphosis
Stem Cell-Mediated Regeneration in Flatworms
Salamanders: Epimorphic Limb Regeneration
Luring the Mechanisms of Regeneration from Zebrafish Organs
Regeneration in Mammals

23. Aging and Senescence
Genes and Aging
Random Epigenetic Drift
Stem Cells and Aging
Exceptions to the Aging Rule

VII. DEVELOPMENT IN WIDER CONTEXTS

24. Development in Health and Disease: Birth Defects, Endocrine Disruptors, and Cancer
The Role of Chance
Genetic Errors of Human Development
Teratogenesis: Environmental Assaults on Animal Development
Endocrine Disruptors: The Embryonic Origins of Adult Disease
Transgenerational Inheritance of Developmental Disorders
Cancer as a Disease of Development
Coda

25. Development and the Environment: Biotic, Abiotic, and Symbiotic Regulation of Development
The Environment as a Normal Agent in Producing Phenotypes
Polyphenic Life Cycles
Developmental Symbioses
Coda

26. Development and Evolution: Developmental Mechanisms of Evolutionary Change
Descent with Modification: Why Animals Are Alike and Different
Preconditions for Evolution: The Developmental Structure of the Genome
Deep Homology
Mechanisms of Evolutionary Change
Developmental Constraints on Evolution
Selectable Epigenetic Variation
Coda

Glossary
Author Index
Subject Index

A classic gets a new coauthor and a new approach: Developmental Biology, Eleventh Edition, keeps the excellent writing, accuracy, and enthusiasm of the Gilbert Developmental Biology book, streamlines it, adds innovative electronic supplements, and creates a new textbook for those teaching Developmental Biology to a new generation.
Several new modes of teaching are employed in the new Gilbert and Barresi textbook. The videos explaining development--as well as those from Mary Tyler's Vade Mecum--are referenced throughout the book, and several other valuable new elements have been added.

Additional updates include:
• An increased emphasis on stem cells, which are covered extensively and early in the book.
• Sex determination and gametogenesis, instead of being near the end of the volume, are up front, prior to fertilization.
• Greatly expanded coverage of neural development, comprising a unit unto itself.
• Coverage of new experiments on morphogenesis and differentiation, as well as new techniques such as CRISPR.