DIABETIC NEPHROPATHY. PATHOPHYSIOLOGY AND CLINICAL ASPECTS

1. A Historical Overview of Diabetic Nephropathy
2. Clinical Features and Natural Course of Diabetic Nephropathy
3. Global, Regional, and Ethnic Differences in Diabetic Nephropathy
4. Diabetic Nephropathy in Children and Adolescents
5. Renal Disease in Obesity, Metabolic Syndrome and Diabesity
6. Introduction to Pathogenetic Mechanisms of Diabetic Nephropathy
7. The Genetics of Diabetic Nephropathy
8. Pathology of the Kidney in Diabetes
9. The Mesangial Cell in Diabetic Nephropathy
10. The Glomerular Endothelium in Diabetic Nephropathy: Role of Heparanase
11. The Podocyte in Diabetic Nephropathy: Recent Advances
12. Inflammatory Processes in Diabetic Glomeruli
13. Proteinuria and Tubulotoxicity
14. Tubuloglomerular Communication in Diabetic Nephropathy
15. Mechanisms of Interstitial Fibrosis in Diabetic Nephropathy
16. Microvascular Damage and Hemodynamic Alterations in Diabetic Nephropathy
17. Coagulation and Hemostasis in Diabetic Nephropathy
18. Renal Hemodynamics in Diabetic Kidney Disease: Relevance for Intervention
19. Microvascular Complications in the Eye: Diabetic Retinopathy
20. Hypertension in Diabetic Kidney Disease
21. Macrovascular Involvement in Diabetes: Renal Artery Stenosis
22. Atherosclerosis and Diabetic Nephropathy
23. Animal Models of Diabetic Kidney Disease
24. (Clinical) Trial and Error in Diabetic Nephropathy
25. Treatment Goals in Diabetic Nephropathy
26. Kidney Transplantation and Diabetic Nephropathy
27. Health Programmes in Low- and Middle-Income Countries
28. Omics in Diabetic Kidney Disease
29. Future and Novel Compounds in the Treatment of Diabetic Nephropathy

This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed.
Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.

Features
• Covers all the current knowledge regarding diabetic nephropathy
• Presented in an integrated “bench-to-bedside” approach
• Written by international experts in the field

Authors
• Joris J. Roelofs, MD, PhD. (1972) studied medicine at the KU Leuven, Belgium, and the VUmc School of Medical Sciences, Amsterdam, the Netherlands, where he received his MD degree. He received his PhD degree from the University of Amsterdam Faculty of Medicine with studies on coagulation in renal disease, after which he worked as a Postdoctoral Research Fellow in the Kirkland Center for Lupus Research (Cornell University Medical College, New York City). Joris Roelofs is Associate Professor of Renal Pathology and Principal Investigator in the Department of Pathology at the Academic Medical Center, Amsterdam, where he leads translational studies in chronic kidney disease and diabetic nephropathy.
• Liffert Vogt, MD, PhD. (1975) was born in Groningen in the Netherlands, where he completed his medical degree and nephrology PhD. He then moved to the Mario Negri Institute, Bergamo, Italy where he was an international postdoctoral fellow, and then he completed his internal medicine and nephrology training at the Academic Medical Center, Amsterdam, the Netherlands, where he works now as an internist and nephrologist. As a Principal Investigator in his institute, he is leading experimental and clinical studies within the field of diabetes and chronic kidney disease.