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2 Introduction
3 Hematopoiesis and Bone Marrow Histology
4 Bone Marrow Examination and Techniques
5 Synoptic Bone Marrow Reporting
6 Overview of Constitutional and Acquired Bone Marrow Disorders
7 Anemia
8 Overview of Anemia
9 Acquired Anemias
10 Anemias of Inflammation, Chronic Renal Disease, and Cancer
11 Iron Deficiency Anemia
12 Autoimmune Hemolytic Anemias
13 Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn
14 Microangiopathic Hemolytic Anemia
15 Megaloblastic Anemia
16 Acquired Nonneoplastic Sideroblastic Anemia
17 Alcoholism-Associated Anemia
18 Anemia in the Elderly
19 Copper Deficiency-Associated Anemia
20 Acquired Red Cell Aplasia
21 Transient Erythroblastopenia of Childhood
22 Parvovirus-Induced Red Cell Aplasia
23 Paroxysmal Nocturnal Hemoglobinuria
24 Acquired Aplastic Anemia
25 Constitutional Anemias
26 Thalassemia
27 Sickle Cell Anemia
28 Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
29 Pyruvate Kinase Deficiency
30 Hereditary Spherocytosis
31 Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis
32 Diamond-Blackfan Anemia
33 Fanconi Anemia
34 Congenital Dyserythropoietic Anemia
35 Congenital Sideroblastic Anemia
36 Congenital Megaloblastic Anemia
37 Erythrocytosis
38 Constitutional
39 Congenital Erythrocytosis
40 Acquired
41 Acquired Erythrocytosis
42 Benign Leukocyte Disorders in Blood and Bone Marrow
43 Overview of Benign Leukocyte Disorders in Blood and Bone Marrow
44 Pancytopenia
45 Neutropenia
46 Neutrophilia
47 Monocytosis
48 Eosinophilia
49 Basophilia
50 Lymphocytosis
51 Lymphopenia, Constitutional and Acquired
52 Plasmacytosis of Bone Marrow
53 Hematogones in Bone Marrow
54 Lymphoid Aggregates in Bone Marrow
55 Granulomas in Bone Marrow
56 Constitutional Granulocytic Disorders
57 Constitutional Neutropenias
58 Severe Congenital Neutropenia and Cyclic Neutropenia
59 Shwachman-Diamond Syndrome
60 Chediak-Higashi Syndrome
61 Myelokathexis in WHIM Syndrome
62 Constitutional Neutrophil Anomalies
63 Pelger-Huët Anomaly
64 *MYH9*-Related Disorders
65 Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation
66 Megakaryocytic Disorders
67 Overview of Megakaryocytic Disorders
68 Acquired Platelet Disorders With Thrombocytopenia
69 Immune-Mediated Thrombocytopenia
70 Hemolytic-Uremic Syndrome
71 Heparin-Induced Thrombocytopenia (HIT)
72 Thrombotic Thrombocytopenic Purpura
73 Pregnancy-Associated Thrombocytopenia
74 Constitutional Platelet Disorders With Thrombocytopenia
75 Macrothrombocytopenia
76 Thrombocytopenia Absent Radius Syndrome
77 Congenital Amegakaryocytic Thrombocytopenia
78 Gray Platelet Syndrome
79 Wiskott-Aldrich Syndrome-Related Disorders
80 Congenital Thrombotic Thrombocytopenic Purpura
81 Thrombocytosis
82 Thrombocytosis
83 Infection
84 Overview of Infection
85 Hantavirus Pulmonary Syndrome
86 Human Immunodeficiency Virus
87 Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)
88 Parvovirus B19 Infection
89 Bacterial Infections, Blood and Bone Marrow Features
90 Fungal Infections, Blood and Bone Marrow Features
91 Helminthic Infections
92 Malaria
93 Other Protozoan Infections
94 COVID-19 Infection
95 Miscellaneous Nonneoplastic Disorders and Conditions
96 Overview and Classification of Hemophagocytic Disorders in Bone Marrow
97 Hematologic Manifestations of Collagen Vascular Disorders
98 Hematologic Manifestations of Chronic Renal Disorders
99 Lysosomal Storage Diseases With Predominantly Histiocytic Storage
100 Homeopathic Remedies and Medications Affecting Blood and Bone Marrow
101 Other Pregnancy-Associated Hematologic Disorders
102 VEXAS Syndrome
103 Gelatinous Transformation and Other Bone Marrow Stromal Disorders
104 Crystals in Bone Marrow
105 Bone Abnormalities in Bone Marrow Specimens
106 Myeloid Neoplasms
107 Overview and Classification of Myeloid Neoplasms
108 Specialized Testing in Myeloid Neoplasms
109 Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia
110 Myeloproliferative Neoplasms
111 Overview of Myeloproliferative Neoplasms
112 Chronic Myeloid Leukemia, *BCR-ABL1* Positive
113 Chronic Neutrophilic Leukemia
114 Polycythemia Vera
115 Primary Myelofibrosis
116 Essential Thrombocythemia
117 Chronic Eosinophilic Leukemia, Not Otherwise Specified
118 Myeloproliferative Neoplasm, Unclassifiable
119 Mastocytosis
120 Systemic Mastocytosis
121 Mast Cell Leukemia
122 Myeloid and Lymphoid Neoplasms With Eosinophilia and Gene Rearrangements
123 Myeloid and Lymphoid Neoplasms With *PDGFRA* Rearrangement
124 Myeloid and Lymphoid Neoplasms With *PDGRFB* Rearrangement
125 Myeloid and Lymphoid Neoplasms With *FGFR1* Rearrangement
126 Myeloid and Lymphoid Neoplasms With *FLT3* Rearrangement
127 Myelodysplastic/Myeloproliferative Neoplasms
128 Overview of Myelodysplastic/Myeloproliferative Neoplasms
129 Chronic Myelomonocytic Leukemia
130 Atypical Chronic Myeloid Leukemia, *BCR-ABL1* Negative (aCML)
131 Juvenile Myelomonocytic Leukemia
132 Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis
133 Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable
134 Myelodysplastic Syndromes
135 Overview and Classification of Myelodysplastic Syndromes
136 Clonal Hematopoiesis of Indeterminant Potential (CHIP)
137 Myelodysplastic Syndrome With Single Lineage Dysplasia
138 Myelodysplastic Syndromes With Ring Sideroblasts
139 Myelodysplastic Syndrome With Multilineage Dysplasia
140 Myelodysplastic Syndromes With Excess Blasts
141 Myelodysplastic Syndrome With Isolated del(5q)
142 Myelodysplastic Syndrome, Unclassifiable
143 Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)
144 Acute Myeloid Leukemia
145 Overview of Acute Myeloid Leukemia
146 Familial AML/MDS (Germline Predisposition)
147 Acute Myeloid Leukemia With t(8;21)(q22;q22.1), *RUNX1-RUNX1T1*
148 Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), *CBFB-MYH11*
149 Acute Promyelocytic Leukemia With *PML-RARA*
150 Acute Promyelocytic Leukemia With Variant *RARA* Rearrangement
151 Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3), *KMT2A-MLLT3*
152 Subtypes of Acute Myeloid Leukemia: t(6;9), inv(3), t(1;22), t(9;22), Mutated *NPM1,* Biallelic Mutated *CEBPA,* Mutated *RUNX1*
153 Acute Myeloid Leukemia With Myelodysplasia-Related Changes
154 Therapy-Related Myeloid Neoplasms
155 Acute Myeloid Leukemia With Minimal Differentiation (AML, NOS)
156 Acute Myeloid Leukemia Without Maturation (AML, NOS)
157 Acute Myeloid Leukemia With Maturation (AML, NOS)
158 Acute Myelomonocytic Leukemia (AML, NOS)
159 Acute Monoblastic and Monocytic Leukemia (AML, NOS)
160 Pure Erythroid Leukemia (AML, NOS)
161 Acute Megakaryoblastic Leukemia, Not Otherwise Specified
162 Acute Basophilic Leukemia (AML, NOS)
163 Acute Panmyelosis With Myelofibrosis (AML, NOS)
164 Myeloid Proliferations Related to Down Syndrome
165 Measurable Residual Disease Testing Strategies in AML
166 Blastic Plasmacytoid Dendritic Cell Neoplasm
167 Blastic Plasmacytoid Dendritic Cell Neoplasm
168 Acute Leukemias of Ambiguous Lineage
169 Acute Undifferentiated Leukemia
170 Mixed Phenotype Acute Leukemia
171 Lymphoid Neoplasms
172 Overview of Lymphoid Neoplasms
173 Specialized Testing in Lymphoid Neoplasms
174 B-Precursor Neoplasms
175 B-Lymphoblastic Leukemia
176 Novel Genetic Subtypes of B-Lymphoblastic Leukemia
177 BCR-ABL1-Like ALL
178 Measurable Residual Disease Testing Strategies in ALL
179 T-Precursor Neoplasms
180 T-Lymphoblastic Leukemia/Lymphoma
181 Early T-Cell Precursor Acute Lymphoblastic Leukemia
182 Mature B-Cell Neoplasms
183 Overview and Classification of Mature B-Cell Leukemias, Immunosecretory Lymphomas
184 Monoclonal B-Cell Lymphocytosis
185 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
186 B-Cell Prolymphocytic Leukemia
187 Splenic Marginal Zone Lymphoma
188 Hairy Cell Leukemia
189 Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant
190 Lymphoplasmacytic Lymphoma
191 Gamma Heavy Chain Disease
192 Monoclonal Gammopathy of Undetermined Significance
193 Plasma Cell Myeloma
194 Burkitt Leukemia/Lymphoma
195 Mantle Cell Lymphoma in Blood and Bone Marrow
196 Follicular Lymphoma in Blood and Bone Marrow
197 Marginal Zone Lymphoma in Blood and Bone Marrow
198 Large B-Cell Lymphomas in Blood and Bone Marrow
199 Mature T-/NK-Cell Neoplasms
200 Overview and Classification of Mature T-/NK-Cell Neoplasms in Blood and Bone Marrow
201 T-Cell Prolymphocytic Leukemia
202 T-Cell Large Granular Lymphocytic Leukemia
203 Chronic Lymphoproliferative Disorder of NK Cells
204 Aggressive NK-Cell Leukemia
205 Adult T-Cell Leukemia
206 Mycosis Fungoides/Sézary Syndrome
207 Anaplastic Large Cell Lymphoma in Blood and Bone Marrow
208 Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow
209 Hodgkin Lymphoma in Bone Marrow
210 Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte-Predominant Subtypes
211 Other Neoplasms Involving Bone Marrow
212 Langerhans Cell Histiocytosis in Bone Marrow
213 Posttransplant Lymphoproliferative Disorders in Bone Marrow
214 Metastatic Carcinoma and Sarcoma
215 CAP Protocol
216 Protocol for the Examination of Specimens from Patients with Non-Hodgkin Lymphoma/Lymphoid Neoplasms

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

• Provides practicing pathologists with key details about new entities, newly recognized causes of morphologic change in blood and bone marrow abnormalities, and new strategies for appropriate workup of neoplastic processes—all with a focus on key tests and key differential diagnostic considerations
• Helps pathologists recognize unique blood and bone marrow findings that can be an indicator for specific exposures, such as new medications, new targeted therapies, or toxins
• Integrates updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the increased use of homeopathic remedies
• Contains new chapters covering SARS-CoV-2 infection features in blood and bone marrow; myelodysplastic syndrome (MDS) mimics; blood and bone marrow findings linked to targeted therapies; blood and bone marrow findings linked to other medications; and more
• Updates all existing chapters and contains expanded information on T-cell neoplasms in blood and bone marrow and intravascular large B-cell lymphoma in blood and bone marrow
• Includes details from the WHO’s fifth edition Classification of Tumours of Haematopoietic and Lymphoid Tissues as well as the International Consensus Classification of Hematolymphoid Neoplasms, reflecting new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates
• Discusses molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration
• Clearly delineates numerous genetic disorders often found in blood and bone marrow
• Features nearly 2,600 superb images (many new or updated), including histology and gross pathology photographs, full-color illustrations and schematics, clinical photographs, and radiologic images
• Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
• Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Kathryn Foucar, MD, Distinguished Professor Emerita of Pathology, Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico

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