DIAGNOSTIC PATHOLOGY: SOFT TISSUE TUMORS. 4TH EDITION

• SECTION 1: SOFT TISSUE INTRODUCTION
? INTRODUCTION AND OVERVIEW
4 Gross Examination
6 Grading and Staging
? ANCILLARY TECHNIQUES
12 Soft Tissue Immunohistochemistry
18 Molecular Features of Soft Tissue Tumors
• SECTION 2: DIAGNOSTIC APPROACH TO SOFT TISSUE TUMORS
OVERVIEW
22 Biopsy and Resection of Soft Tissue Tumors
? CLINICAL APPROACH
26 Age- and Location-Based Approach to Diagnosis
HISTOLOGIC APPROACH
28 Pattern-Based Approach to Diagnosis
36 Feature-Based Approach to Diagnosis
• SECTION 3: TUMORS OF ADIPOSE TISSUE
? BENIGN
46 Lipoma
52 Lipomatosis of Nerve
54 Synovial Lipomatosis
56 Angiolipoma
60 Spindle Cell/Pleomorphic Lipoma
66 Chondroid Lipoma
70 Myolipoma
74 Hibernoma
78 Myelolipoma
80 Lipoblastoma
84 Atypical Spindle Cell/Pleomorphic Lipomatous Tumor
88 Lipoblastoma-Like Tumor of Vulva
? INTERMEDIATE, LOCALLY AGGRESSIVE
92 Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma
? MALIGNANT
98 Dedifferentiated Liposarcoma
106 Myxoid Liposarcoma
112 Pleomorphic Liposarcoma
118 Myxoid Pleomorphic Liposarcoma
• SECTION 4: FIBROBLASTIC/MYOFIBROBLASTIC LESIONS
? BENIGN
124 Nodular Fasciitis
130 Proliferative Fasciitis/Myositis
134 Ischemic Fasciitis
136 Myositis Ossificans
140 Fibroosseous Pseudotumor of Digits
144 Fibroma of Tendon Sheath
150 Desmoplastic Fibroblastoma
152 Elastofibroma
154 Angiofibroma of Soft Tissue
158 Mammary-Type Myofibroblastoma
162 Plexiform Myofibroblastoma
166 Intranodal Palisaded Myofibroblastoma
170 Pleomorphic Fibroma
172 Dermatomyofibroma
174 Fibroblastic Connective Tissue Nevus
176 Storiform Collagenoma
178 Keloid
180 Nuchal-Type Fibroma
? INTERMEDIATE (LOCALLY AGGRESSIVE)
182 Palmar/Plantar Fibromatosis
184 Desmoid-Type Fibromatosis
190 EWSR1::SMAD3 Fibroblastic Tumor
? INTERMEDIATE (RARELY METASTASIZING)
194 Dermatofibrosarcoma Protuberans
204 Solitary Fibrous Tumor
212 Low-Grade Myofibroblastic Sarcoma
216 Inflammatory Myofibroblastic Tumor
222 Myxoinflammatory Fibroblastic Sarcoma
230 Superficial CD34(+) Fibroblastic Tumor
? MALIGNANT
234 Adult-Type Fibrosarcoma
236 Myxofibrosarcoma
242 Low-Grade Fibromyxoid Sarcoma
252 Sclerosing Epithelioid Fibrosarcoma
258 Epithelioid Inflammatory Myofibroblastic Sarcoma
• SECTION 5: PEDIATRIC FIBROBLASTIC/MYOFIBROBLASTIC TUMORS
? BENIGN
264 Fibrous Hamartoma of Infancy
268 Calcifying Aponeurotic Fibroma
272 Calcifying Fibrous Tumor
274 Inclusion Body Fibromatosis
276 Hyaline Fibromatosis Syndrome
278 Fibromatosis Colli
280 Gardner Fibroma
? INTERMEDIATE (LOCALLY AGGRESSIVE)
282 Lipofibromatosis
284 Giant Cell Fibroblastoma
? INTERMEDIATE (RARELY METASTASIZING)
288 Infantile Fibrosarcoma
• SECTION 6: FIBROHISTIOCYTIC, HISTIOCYTIC, AND DENDRITIC CELL TUMORS
? BENIGN
294 Dermatofibroma and Fibrous Histiocytoma
300 Deep Benign Fibrous Histiocytoma
302 Epithelioid Fibrous Histiocytoma
306 Localized-Type Tenosynovial Giant Cell Tumor
312 Diffuse-Type Tenosynovial Giant Cell Tumor
318 Cellular Neurothekeoma
322 Xanthomas
326 Solitary (Juvenile) Xanthogranuloma
328 Reticulohistiocytoma
332 Deep Granuloma Annulare
334 Rheumatoid Nodule
336 Langerhans Cell Histiocytosis
338 Extranodal Rosai-Dorfman Disease
342 Crystal-Storing Histiocytosis
? INTERMEDIATE (RARELY METASTASIZING)
344 Plexiform Fibrohistiocytic Tumor
348 Giant Cell Tumor of Soft Tissue
? MALIGNANT
352 Histiocytic Sarcoma
354 Follicular Dendritic Cell Sarcoma
358 Interdigitating Dendritic Cell Sarcoma
• SECTION 7: SMOOTH MUSCLE TUMORS
? BENIGN
362 Smooth Muscle Hamartoma
364 Superficial Leiomyoma
368 Deep Leiomyoma
? INTERMEDIATE
372 Epstein-Barr Virus-Associated Smooth Muscle Tumor
? MALIGNANT
374 Leiomyosarcoma
• SECTION 8: PERICYTIC (PERIVASCULAR) TUMORS
? BENIGN
382 Glomus Tumors (and Variants)
388 Myopericytoma
392 Myofibroma and Myofibromatosis
396 Angioleiomyoma
• SECTION 9: TUMORS OF SKELETAL MUSCLE
? BENIGN
400 Focal Myositis
402 Adult Rhabdomyoma
404 Fetal Rhabdomyoma
406 Genital Rhabdomyoma
408 Cardiac Rhabdomyoma
? MALIGNANT
410 Embryonal Rhabdomyosarcoma
416 Alveolar Rhabdomyosarcoma
422 Spindle Cell/Sclerosing Rhabdomyosarcoma
426 Pleomorphic Rhabdomyosarcoma
430 Epithelioid Rhabdomyosarcoma
• SECTION 10: VASCULAR TUMORS (INCLUDING LYMPHATICS)
? BENIGN
434 Papillary Endothelial Hyperplasia
436 Bacillary Angiomatosis
438 Cutaneous Epithelioid Angiomatous Nodule
440 Congenital Hemangioma
444 Infantile Hemangioma
448 Lobular Capillary Hemangioma
450 Epithelioid Hemangioma
454 Spindle Cell Hemangioma
458 Intramuscular Angioma
462 Hobnail Hemangioma
464 Acquired Tufted Angioma
466 Microvenular Hemangioma
468 Sinusoidal Hemangioma
470 Glomeruloid Hemangioma
472 Anastomosing Hemangioma
476 Synovial Hemangioma
478 Angiomatosis
480 Lymphangioma
484 Massive Localized Lymphedema
486 Atypical Vascular Lesion
? INTERMEDIATE (LOCALLY AGGRESSIVE)
488 Kaposiform Hemangioendothelioma
? INTERMEDIATE (RARELY METASTASIZING)
490 Papillary Intralymphatic Angioendothelioma
492 Retiform Hemangioendothelioma
494 Composite Hemangioendothelioma
496 Pseudomyogenic Hemangioendothelioma
? MALIGNANT
500 Epithelioid Hemangioendothelioma
504 Angiosarcoma
510 Kaposi Sarcoma
• SECTION 11: CHONDROOSSEOUS TUMORS
? BENIGN
520 Soft Tissue Chondroma
526 Synovial Chondromatosis
MALIGNANT
530 Extraskeletal Osteosarcoma
534 Extraskeletal Mesenchymal Chondrosarcoma
• SECTION 12: PERIPHERAL NERVE SHEATH TUMORS
? BENIGN
540 Solitary Circumscribed Neuroma
542 Schwannoma
556 Neurofibroma
566 Perineurioma
572 Hybrid Nerve Sheath Tumor
576 Granular Cell Tumor
582 Dermal Nerve Sheath Myxoma
586 Ganglioneuroma
590 Neuromuscular Choristoma
? MALIGNANT
592 Malignant Peripheral Nerve Sheath Tumor
600 Epithelioid Malignant Peripheral Nerve Sheath Tumor
604 Malignant Melanotic Nerve Sheath Tumor
606 Ectomesenchymoma
• SECTION 13: GENITAL STROMAL TUMORS
610 Fibroepithelial Stromal Polyp
612 Angiomyofibroblastoma
616 Cellular Angiofibroma
620 Deep (Aggressive) Angiomyxoma
• SECTION 14: TUMORS OF MESOTHELIAL CELLS
? BENIGN
626 Adenomatoid Tumor
628 Peritoneal Inclusion Cyst
630 Well-Differentiated Papillary Mesothelial Tumor
? MALIGNANT
634 Malignant Mesothelioma
• SECTION 15: HEMATOPOIETIC TUMORS IN SOFT TISSUE
642 Solitary Extramedullary Plasmacytoma
644 Myeloid Sarcoma
646 Lymphoma of Soft Tissue
• SECTION 16: TUMORS OF UNCERTAIN DIFFERENTIATION
? BENIGN
650 Intramuscular Myxoma
654 Juxtaarticular Myxoma
656 Superficial Angiomyxoma
660 Acral Fibromyxoma
664 Pleomorphic Hyalinizing Angiectatic Tumor
668 Aneurysmal Bone Cyst of Soft Tissue
670 Ectopic Hamartomatous Thymoma
? INTERMEDIATE (LOCALLY AGGRESSIVE)
674 Hemosiderotic Fibrolipomatous Tumor
? INTERMEDIATE (RARELY METASTASIZING)
676 Atypical Fibroxanthoma
682 Angiomatoid Fibrous Histiocytoma
690 Ossifying Fibromyxoid Tumor
696 Myoepithelioma of Soft Tissue
704 Phosphaturic Mesenchymal Tumor
? MALIGNANT
706 Synovial Sarcoma
718 Epithelioid Sarcoma
724 Alveolar Soft Part Sarcoma
728 Clear Cell Sarcoma
732 Perivascular Epithelioid Cell Tumor (PEComa)
740 Desmoplastic Small Round Cell Tumor
746 Extraskeletal Ewing Sarcoma
752 Extraskeletal Myxoid Chondrosarcoma
756 Extrarenal Rhabdoid Tumor
760 Intimal Sarcoma
• SECTION 17: UNDIFFERENTIATED/UNCLASSIFIED SARCOMAS
764 Undifferentiated Pleomorphic Sarcoma
768 Undifferentiated Round Cell Sarcoma With CIC::DUX4 Fusion
774 BCOR::CCNB3 Fusion-Positive Sarcoma
778 Undifferentiated Round Cell Sarcoma with
EWRS1::NFATC2 Fusion
782 Undifferentiated Round Cell Sarcoma with EWRS1::PATZ1 Fusion
786 NTRK-Rearranged Spindle Cell Neoplasms
790 GLI1-Rearranged Epithelioid Neoplasms
• SECTION 18: MESENCHYMAL TUMORS OF GASTROINTESTINAL TRACT
796 Benign Neural Gastrointestinal Polyps
800 Gastrointestinal Stromal Tumor
816 Gastrointestinal Schwannoma
818 Gastrointestinal Smooth Muscle Neoplasms
822 Inflammatory Fibroid Polyp
826 Gangliocytic Paraganglioma
828 Plexiform Fibromyxoma
832 Malignant Gastrointestinal Neuroectodermal Tumor
836 Gastroblastoma
• SECTION 19: OTHER ENTITIES
? BENIGN
842 Amyloidoma
844 Ganglion Cyst
846 Tumoral Calcinosis
848 Idiopathic Tumefactive Fibroinflammatory Lesions
852 Tenosynovitis with Psammomatous Calcifications
854 Myxochondroid Metaplasia of Plantar Foot
856 Cardiac Myxoma
860 Cardiac Fibroma
862 Congenital Granular Cell Epulis
864 Sinonasal Tract Angiofibroma
868 Sinonasal Glomangiopericytoma
874 Ectopic Meningioma
876 Glial Heterotopia
? INTERMEDIATE
878 Paraganglioma
886 Peripheral Hemangioblastoma
888 Melanotic Neuroectodermal Tumor of Infancy
890 Ependymoma of Soft Tissue
? MALIGNANT
892 Metastatic Tumors to Soft Tissue Sites
896 Neuroblastoma and Ganglioneuroblastoma
906 Extraaxial Soft Tissue Chordoma
908 Embryonal Sarcoma of Liver
910 Primary Pulmonary Myxoid Sarcoma
916 Biphenotypic Sinonasal Sarcoma
920 Spindle Epithelial Tumor With Thymus-Like Elements
922 Gynecologic Neoplasms Mimicking Soft Tissue Tumors

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the wide range of often difficult-to-diagnose variants and subtypes in soft tissue tumors, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Soft Tissue Tumors is a visually stunning, one-stop resource for every practicing pathologist, oncologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

Features:
• Provides up-to-date, comprehensive coverage of soft tissue pathology combined with accurate, concise clinicopathologic descriptions, helping you quickly identify tumors and establish actionable diagnoses
• Contains hundreds of chapters with separate Benign, Intermediate, and Malignant sections to provide the fullest diagnostic picture possible
• Features new chapters covering the recently recognized EWSR1::SMAD3 fibroblastic tumor, plexiform myofibroblastoma, anastomosing hemangioma, myxoid pleomorphic liposarcoma, and more
• Includes details throughout on new immunostains and molecular genetics and testing
• Features an image-rich layout with more than 4,400 print and online-only images—including high-quality photomicrographs, gross photographs, radiologic images, and detailed medical illustrations—to make tumor identification and diagnosis faster and easier
• Provides an organized framework that includes "Approach to Diagnosis" chapters designed to help you successfully recognize and diagnose challenging soft tissue tumors with the availability of common patterns and histologic features
• Includes updates based on the most recent WHO Classification of Tumors: Soft Tissue and Bone Tumors
• Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
• Includes an eBook version that enables you to access all text, figures, and references with the ability to search, customize your content, make notes and highlights, and have content read aloud

Author
Matthew R. Lindberg, MD, Director, Soft Tissue Pathology Division, Associate Professor of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas