DIAGNOSTIC PEDIATRIC HEMATOPATHOLOGY. 2ND EDITION

Introduction
• Section I. General and Non-neoplastic Hematopathology:
1. Hematologic values in the healthy fetus, neonate, and child Maria A. Proytcheva
2. Normal bone marrow Maria A. Proytcheva
3. Disorders of erythrocyte production: nutritional deficiencies, iron deficient, and sideroblastic anemia Angela E. Thomas and Barbara J. Bain
4. Disorders of hemoglobin synthesis thalassemias and structural hemoglobinopathies Archana M. Agarwal and Anton Rets
5. Hemolytic anemias: immune- and non-immune-mediated hemolytic anemias, RBC membrane defects, and hereditary disorders due to RBC enzyme defects Maria A. Proytcheva
6. Anemias in children in developing countries Simon Osongo and Elizabeth Kagotho
7. Inherited bone marrow failure syndromes Jyotinder N. Punia, M. Tarek Elghetany and Maria A. Proytcheva
8. Peripheral blood and bone marrow manifestations of metabolite storage diseases Andrea N. Marcogliese
9. Reactive lymphadenopathies Maria A. Proytcheva
10. Spleen: normal architecture and non-neoplastic and neoplastic lesions Flavia G. N. Rosado, Genevieve M. Craine, and Dennis P. O'Malley
11. Chromosome abnormalities of hematologic malignancies: a practical guide to cytogenetic analysis Katrin M. Leuer and Pamela Rathbun
• Section II. Neoplastic Hematopathology:
12. Molecular diagnostics of pediatric acute leukemias in the era of high throughput sequencing Somak Roy and Erin H. Breese
13. Immunophenotypic characterization of pediatric leukemia/lymphoma by flow cytometry including minimal residual disease detection Sunita Park and Yi Zhou
14. Myeloproliferative neoplasms and their mimics Robert B. Lorsbach
15. Mastocytosis and related disorders Robert B. Lorsbach
16. Juvenile myelomonocytic leukemia and related disorders John Kim Choi
17. Myelodysplastic syndromes Robert B. Lorsbach
18. Acute myeloid leukemia and related precursor neoplasms Robert B. Lorsbach
19. Hematologic abnormalities in individuals with Down syndrome John Kim Choi
20. Lymphoblastic neoplasms Mihaela Onciu
21. Advances in prognostication and treatment of pediatric acute leukemia – substantial revision Nobuko Hijiya and Jing Chen
22. Bone marrow findings post-chemotherapy and hematopoietic stem cell transplantation Maria A. Proytcheva
23. Pediatric small blue cell tumors metastatic to the bone marrow Maria A. Proytcheva
24. Pediatric mature B-cell non-Hodgkin lymphomas Rodney R. Miles and Sherrie L. Perkins
25. Pediatric mature T-cell and NK-cell non-Hodgkin lymphomas Rodney R. Miles and Sherrie L. Perkins
26. Classic Hodgkin lymphoma and nodular lymphocyte predominant B-cell lymphoma Robert B. Lorsbach and Mihaela Onciu
27. Immunodeficiency-associated lymphoproliferative disorders: congenital immune deficiencies, acquired immune deficiencies, and post-transplant lymphoproliferative disorders Michele Paessler and Brian Lockhart
28. Histiocytic proliferations in childhood Jennifer Picarsic, Ashish Kumar, and Rebecca Marsh
29. Cutaneous and subcutaneous lymphomas in children Jasmine Saleh, Woo Jin Lee, and Joan Guitart
Index.

In this thoroughly revised and updated second edition, the emphasis remains on providing a practical and up-to-date guide for the practicing pathologist when evaluating peripheral blood, bone marrow, and lymph node specimens from pediatric patients. Over 400 high-quality color figures enhance the understanding of the morphology and immunophenotypic features of benign and neoplastic hematologic disorders in children. The text also highlights the use of ancillary studies – such as flow cytometry and molecular techniques – in the diagnosis and post-therapy monitoring of pediatric hematologic malignancies. The importance of understanding of normal development of the hematopoietic system as well as the unique diagnostic features of benign and malignant hematologic disorders in children is retained, with chapters authored by experienced pediatric hematopathologists and clinical scientists drawn from major children's hospitals across the USA, Europe, and Africa. The print book comes with access to the text and expandable figures online at Cambridge Core, which can be accessed via a code printed inside the book.
• Contains over 400 high-quality colour figures that are fully described to illustrate the morphologic, immunophenotypic and genetic findings of the relevant diagnostic features of hematologic malignancies in children
• Approaches the subject from a practical standpoint, providing quick but authoritative answers to clinicians who may encounter patients with these diseases in their everyday clinical practice. Chapters are authored by pathologists and laboratory scientists with extensive experience in the field, passing on their pearls of wisdom
• Fully updated second edition that incorporates guidance and new diagnostic entities from the recently published WHO-5 Classification and ICC Classifications
• Includes access to an HTML version of the text on Cambridge Core, alongside expandable figures and resources, via a code inside the book