DIFFUSE LOW-GRADE GLIOMAS IN ADULTS

1. Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Patients with Diffuse Low-Grade Gliomas
2. Epidemiology of Diffuse Low Grade Gliomas
3. Molecular Epidemiology of Diffuse Low-Grade Glioma
4. Molecular-Genetic Classification of Gliomas and Its Practical Application to Diagnostic Neuropathology
5. Towards an Intermediate Grade in Glioma Classification
6. Pathogenesis of Diffuse Low-Grade Gliomas
7. Dissemination of Diffuse Low-Grade Gliomas: Tools and Molecular Insights
8. The Genomics of Diffuse Low-Grade Gliomas
9. Diffuse Low-Grade Glioma Associated Stem Cells
10. Molecular Imaging of Diffuse Low Grade Glioma
11. Clinical Presentation in Diffuse Low-Grade Gliomas
12. Epilepsy and Diffuse Low-Grade Gliomas
13. Quality of Life in Patients with Diffuse Low-Grade Glioma
14. Magnetic Resonance Oncometabolic Imaging in DLGG Beyond the Image
15. Positron-Emission-Tomography in Diffuse Low-Grade Gliomas
16. Dynamics of DLGG and Clinical Implications
17. Natural History and Spontaneous Prognostic Factors
18. Language, Cognitive and Emotional Evaluations
19. Task-Based and Resting-State Functional MRI in DLGG
20. Diffusion Magnetic Resonance Imaging in Diffuse Low-Grade Gliomas
21. Magnetoencephalography, Functional Connectivity and Neural Network Topology in Diffuse Low-Grade Gliomas
22. Interactions Between Diffuse Low-Grade Glioma (DLGG), Brain Connectome and Neuroplasticity
23. Surgery for Diffuse Low-Grade Gliomas (DLGG) Oncological Outcomes
24. Surgery for Diffuse Low-Grade Gliomas (DLGG) Functional Ouctomes
25. Chemotherapy for Diffuse Low Grade Gliomas
26. Radiation Therapy in the Treatment of Low Grade Gliomas
27. Functional Rehabilitation in Patients with DLGG
28. New Individualized and Dynamic Therapeutic Strategies in DLGG
29. Emerging Therapies for Diffuse Low Grade Glioma
30. Pregnancy and Diffuse Low-Grade Gliomas
31. Biomathematical Modeling of DLGG
32. Resection Probability Maps of Glioma
33. The Concept of Onco-Functional Balance in the Management of DLGG
34. The Origins of Diffuse Low-Grade Gliomas
35. From Management of Incidental DLGG to Screening of Silent DLGG

The second edition of this well-received volume has been revised and updated to reflect the advances in pathological classification and molecular epidemiology of diffuse low-grade gliomas (DLGG) in adults and offers an updated review on individualized therapies. This book presents the latest research pertaining to the diagnosis, genetics, therapy and management of DLGGs. It extensively covers recent research on the natural history of DLGGs and their interaction with the brain and reviews the new diagnostic and therapeutic strategies which increase survival and quality of life of the patient.
New topics covered are the management of DLGGs during pregnancy, functional rehabilitation of patients with DLGG and the onco-functional balance in DLGG, among others. The reader will have the opportunity to gain insight in both clinical and basic science aspects of this type of tumor and learn about the application of novel imaging techniques such as diffussion tensor imaging.
Edited by a leading expert in the field and authored by a team of recognised specialists, this book is a valuable resource for medical oncologists, neuro-oncologists and neurologists.

Features
• Exhaustively reviews molecular epidemiology, as well as molecular and pathological classification of DLGGs
• Updated to cover the latest personalised therapies and advances in disease management.
• Covers both oncological and functional perspectives on DLGGs in adults
• Includes new chapters on resection probability map, pregnancy and patient rehabilitation, among others.

Authors
Hugues Duffau, after his residency and habilitation 2002 at the University Paris VI, became Professor 2006 and Head of the Department of Neurosurgery, Montpellier, France in 2007.
He is one of the leading experts in low grade glioma surgery and well known for his holistic view of the brain and his pursuit for changing paradigms in neurooncological surgery. For him, a deep understanding of anatomy, functional imaging, intraoperative mapping and neuropsycological assessments is mandatory to open new doors to personalized therapeutic strategies for patients.
With 227 publications and four books, he is in the editorial board of five journals and member of several neurosurgical and neuroncological societies.