DISORDERS OF SLEEP AND CIRCADIAN RHYTHMS IN PARKINSON'S DISEASE

This book is the first to take into account the rapidly growing body of knowledge
on the relation between sleep and PD. Gathering contributions from internationally
recognized experts, it provides a unique source of in-depth information on sleep and
circadian dysregulation in Parkinson’s disease. The book is divided into two parts: the
first comprises chapters on normal sleep-wake homeostasis, followed by changes that
occur in PD and discussions of available tools for the assessment of sleep-wake cycles in
PD. In the second part, sleep and circadian disorders associated with PD are described
in individual chapters, including sections on epidemiology, etiology, pathogenesis,
differential diagnosis, and treatment. Controversies in the field, such as the relations
between cognition and sleep, fatigue and sleepiness, and the potential impact of surgical
therapies on sleep-wake cycles are discussed separately. The book closes with a chapter
on future directions and unmet needs in the field of sleep, circadian biology and PD. This
comprehensive text offers a readily accessible resource for clinicians and researchers
alike, addressing the needs of neurologists, sleep and movement disorders specialists,
and all trainees and allied health professionals involved in the care of patients affected by
Parkinson’s disease.

- First book dedicated to the topic of sleep dysfunction in Parkinson's
disease
- Provides a comprehensive and up-to-date overview of the field
- With contributions from leading international experts

Authors

Dr. Aleksandar Videnovic is Assistant Professor of Neurology at Northwestern University Feinberg School of Medicine in Chicago, USA. His clinical and research expertise is in Parkinson's Disease and movement disorders and in Sleep Medicine. Dr. Videnovic's research has been focused on sleep dysfunctions in movement disorders with an emphasis on Parkinson's disease. His research is supported by the United States National Institute of Health, the American Academy of Neurology Foundation, the Michael J. Fox Foundation for Parkinson Research, and the National Parkinson Foundation.

Dr. Birgit Högl is Professor of Neurology at Innsbruck Medical University in Innsbruck, Austria. She is a world-renowned expert in the field of Sleep Medicine. Professor Högl has authored many landmark studies related to the interface of sleep and movement disorders, in particular Parkinson's disease, REM Sleep Behavior Disorder and Restless Legs Syndrome.

Contents
1.Regulation of Sleep and Wake Homeostasis
2.Neurochemistry of the Sleep-Wake Cycle in Parkinson’s Disease
3.Impaired Sleep and Alertness in Parkinson’s Disease: “What Did We Learn from Animal Models?”
4.Objective Measures of the Sleep–Wake Cycle in Parkinson’s Disease
5.Subjective Assessment of Sleep and Sleepiness in Parkinson’s Disease
6.Insomnia in Parkinson’s Disease
7.Sleep Disordered Breathing in Parkinson’s Disease
8.Excessive Daytime Somnolence Associated with Parkinson’s Disease
9.Dysregulation of Circadian System in Parkinson’s Disease
10.REM Sleep Behavior Disorder
11.Quality Control for Diagnosis of REM Sleep Behavior Disorder: Criteria, Questionnaires, Video, and Polysomnography
12.Restless Legs Syndrome and Periodic Limb Movements in Parkinson’s Disease
13.Fatigue and Sleepiness in Parkinson’s Disease Patients
14.Cognition and the Sleep–Wake Cycle in Parkinson’s Disease
15.Impact of Surgical Therapies on Sleep and Alertness in Parkinson’s Disease
16.Sleep Disorders in Atypical Parkinsonisms