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138,32 €1. An Overview of Sleep Physiology and Sleep Regulation
2. Neuronal Networks Regulating Sleep and Arousal: Effect of Drugs
3. Classification of Sleep Disorders
4. Development of New Therapeutical Agents for Treatment of Insomnia and Other Sleeps Disorders
5. Low-Dose Doxepin for Insomnia
6. Lorediplon: A New GABA
7. Zolpidem Sublingual Formulations
8. Eszopiclone: Review and Clinical Applications in Chronic and Comorbid Insomnia
9. Orexin/Hypocretin Antagonists in Insomnia: From Bench to Clinic
10. Modafinil and Armodafinil
11. Sodium Oxybate (Xyrem
12. Cell Therapy to Treat Narcolepsy
13. Tasimelteon
14. The Past, Present, and Future of Drug Development and Treatment in Sleep Disorders
Following reviews on sleep physiology, regulation, pharmacology, and the neuronal networks regulating sleep and awakening, as well as a classification of sleep disorders, this book presents a number of major breakthroughs in the treatment of those disorders. These include recently approved drugs for treating insomnia, such as Doxepin; variations on previously approved molecules, e.g. Zolpidem sublingual preparation; or new chemical entities in advanced stages of clinical development, e.g. Orexin antagonists. Further topics discussed include drugs acting on the GABA receptor, such as Lorediplon and Eszopiclone; the treatment of excessive daytime drowsiness with cell therapy and drugs such as Modafinil, Armodafinil and Sodium oxybate; and the use of Tasimelteon in the treatment of circadian sleep disorders.
Features
• Maximizes reader insights into recent breakthrough in drug treatment
• Describes drug development from bench to clinic
• Treats both basic research and clinical applications
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