ENDOTOXIN DETECTION AND CONTROL IN PHARMA, LIMULUS, AND MAMMALIAN SYSTEMS

Introduction
Section I Pharma
Historical Perspectives
Risk, Control and Compliance.
Sterility and Beyond
LVPs and SMDs
Specification Determination
Static and Dynamic Models (Biodiversity and Heterogeneity)
Test Development and Validation
Diminishing Analytics
Control in Biologics Manufacture
Depyrogenation and Medical Devices
Nanoparticles / Problematic Drug Types
New Frontiers
Section II Limulus
Evolution, a Living Fossil and Other Model Arthropods
Water, Water Everywhere
Survival and Mass Extinction Events
Limulus Soup / Hemolymph
Is Innate Modeling Enough?
A Foreboding
Section III Mammalian
Innate is Inborn
The Host Response: Fever and Inflammation
. Parallel Immune Systems: Architecture and Mechanisms
Structural Change is Functional Change (Hand in Glove)
Endotoxin and Adjuvanticity in Vaccinology
Advances in Diagnostics
The Big S.

The text includes chapters from world-renowned experts on various topics centered around endotoxin detection and control. The study of endotoxin and its multiple interfaces is a journey, an arduous one, but one in which a strict discipline and compartmentalization or segmentation (like the Hox genes that provide the unfolding of metazoan body plans) allows the reader time and space to learn at her own pace and to choose the knowledge set that is most relevant at the time and for the task at hand. Access as well the literature references are included with each chapter to broaden knowledge via the links provided on the book's sister website. While perhaps too grandiose to say out loud, one can feel the excitement today as scientific knowledge can be brought down in printed form or from on-line sources as an archetype for our own personal interaction not just with living nature but with man's ideas and abstractions of her as he encompasses and harnesses her secrets.The cutting edge of science is neither fully hardened truth nor fable, but rather a fanciful intermingling of story, like the connecting of stars into constellations.The excitement of today, the readily interconnectedness of science, often seems drained rather than infused into modern texts.The ideas of Pasteur Koch, Lister, Darwin, Watson, Crick, Levin, Bang, Woese, Janeway, Beutler, Medzhitov, Burnet and many others color this story as centered around one specific vantage: Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems is essential for pharmaceutical scientists, microbiologists, immunologists and life science students.

Features
• Provides the reader with a specializd vantage point from which to view the interrelatedness of various general systems of science
• Teaches microbiology, genetics, evolution, immunology as well as pharmaceutical manufacturing control including a view of the regulatory aspects
• Shows how endotoxins presents a unique vantage of a long view of life as a struggle against prokaryotic invaders and can be seen as shaping the evolving genetics and survival mechanisms of multicellular life-forms
• Presents the most up-to-date and thorough treatment of the subject as well as a host of interrelated topics written by a host of international experts and pioneers of industry
• Includes access to thorough literaure review links on the books' sister website

Author
Kevin Williams graduated from Texas A&M in 1982 with a BS in Microbiology. From there spent 30 years at Eli Lilly in Indianapolis. After retirement he has been at Hospira, Lonza, GE, and now BioMerieux .