EPIGENETIC BIOMARKERS AND DIAGNOSTICS

Features:
- Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics.
- Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics.
- Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications.
- Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases.
- Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies.

Author
José Luis García-Giménez, CIBER Enfermedades Raras, Centre for Biomedical Research on Rare Diseases, University of Valencia, Spain.

Table Of Contents:
Preface
1. Epigenetic Biomarkers: New findings, perspectives, and future directions in diagnostics
2. The importance of Biobanks in epigenetic studies
3. Epigenetic Mechanisms as Key Regulators in Disease. Clinical Implications
4. The evolution of new technologies and methods in clinical epigenetics research
5. Biomarkers and methodologies for monitoring epigenetic drug effects in cancer
6. Genome-wide techniques for the study of clinical epigenetic biomarkers
7. Sequenom MassARRAY technology for the analysis of DNA methylation. Clinical applications
8. The role of Methylation-specific PCR and associated techniques in clinical diagnostics
9. Pyrosequencing and its application in epigenetic clinical diagnostics
10. Mass spectrometry for the identification of post-translational modifications in histones and its application in clinical epigenetics
11. High-throughput analysis of non-coding RNAs: implications in clinical epigenetics
12. Circulating non-coding RNAs as clinical biomarkers
13. DNA methylation biomarkers in lung cancer
14. DNA methylation alterations as biomarkers for Prostate Cancer
15. DNA methylation in breast cancer
16. DNA methylation in obesity and associated diseases
17. DNA Methylation Biomarkers in Asthma and Allergy
18. DNA Methylation in Pregnancy Complications
19. Epigenetics in Infectious Diseases
20. DNA Methylation in Neurodegenerative Diseases
21. The histone code and disease: post-translational modifications as potential prognostic factors for clinical diagnosis
22. Histone Post-Translational Modifications and Chromatin Remodelers in Prostate Cancer
23. Histone post-translational modifications in breast cancer and their use in clinical diagnosis and prognosis
24. Histone variants and post-translational modifications in spermatogenesis and infertility
25. Circulating histones and nucleosomes as biomarkers in sepsis and septic shock
26. Chromatin landscape and epigenetic signatures in neurological disorders: emerging perspectives for biological and clinical research
27. MicroRNAs deregulation in lung cancer and their use as clinical tools
28. Circulating Nucleic Acids as Prostate Cancer Biomarkers
29. microRNAs in breast cancer and their value as biomarkers
30. microRNAs in bone and soft tissue sarcomas and their value as biomarkers
31. miRNAs in the pathophysiology of diabetes and their value as biomarkers