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91,84 €Features:
- Discusses technologies that are critical for epigenetic research and application.
- Includes epigenetic applications for state-of-the-art technologies.
- Contains a global perspective on the future of epigenetics.
Author
Yujun George Zheng, Associate Professor, Department of Pharmaceutical and Biomedical Sciences, University of Georgia.
Table Of Contents:
1. The State of the Art of Epigenetic Technologies
2. Technologies for the Measurement and Mapping of Genomic
5-Methylcytosine and 5-Hydroxymethylcytosine
3. High-Throughput Sequencing-Based Mapping of Cytosine Modifications
4. Application of Mass Spectrometry in Translational Epigenetics
5. Techniques Analyzing Chromatin Modifications at Specific Single Loci
6. Comprehensive Analysis of Mammalian Linker-Histone Variants and Their Mutants
7. Crystallography-Based Mechanistic Insights into Epigenetic Regulation
8. Chemical and Genetic Approaches to Study Histone Modifications
9. Peptide Microarrays for Profiling of Epigenetic Targets
10. Current Methods for Methylome Profiling
11. Bioinformatics and Biostatistics in Mining Epigenetic Disease Markers and Targets
12. Computational Modeling to Elucidate Molecular Mechanisms of Epigenetic Memory
13. DNA Methyltransferase Inhibitors for Cancer Therapy
14. Histone Acetyltransferases: Enzymes, Assays, and Inhibitors
15. In Vitro Histone Deacetylase Activity Screening: Making a Case for Better Assays
16. Enzymatic Assays of Histone Methyltransferase Enzymes
17. Histone Methyltransferase Inhibitors for Cancer Therapy
18. Discovery of Histone Demethylase Inhibitors
19. Histone Demethylases: Background, Purification, and Detection
20. Animal Model Study of Epigenetic Inhibitors
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