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136,34 ۥ Section I: Introduction
• Section II: Where Am I? Genomic Features and DNA Sequence Principles Defining Sites of Epigenetic Regulation: Machine Learning
Chapter 1. Computational Identification of Polycomb/Trithorax Response Elements
Chapter 2. Modeling Chromatin States
Chapter 3. Crossing Borders: Modeling Approaches to Understand Chromatin Domains and Their Boundaries
Chapter 4. Inferring Chromatin Signaling From Genome-Wide ChIP-seq Data
• Section III: Everything’s Moving: In Vivo Dynamics of Epigenetic Regulators: Kinetic Models Based on Ordinary Differential Equations
Chapter 5. “In Vivo Biochemistry”: Absolute Quantification and Kinetic Modeling Applied to Polycomb and Trithorax Regulation
Chapter 6. Modeling Distributive Histone Modification by Dot1 Methyltransferases: From Mechanism to Biological Insights
• Section IV: Reconciling Randomness and Precision: Bistable Epigenetic Memory and Switching: Stochastic Models
Chapter 7. Modeling Bistable Chromatin States
Chapter 8. Quantitative Environmentally Triggered Switching Between Stable Epigenetic States
• Section V: The Third and Fourth Dimensions: Chromosomal Long Range Interactions: Polymer Models
Chapter 9. On the Nature of Chromatin 3D Organization: Lessons From Modeling
Chapter 10. From Chromosome Conformation Capture to Polymer Physics and Back: Investigating the Three-Dimensional Structure of Chromatin Within Topological Associating Domains
Chapter 11. A Combination Approach Based on Live-Cell Imaging and Computational Modeling to Further Our Understanding of Chromatin, Epigenetics, and the Genome
Chapter 12. Capturing Chromosome Structural Properties From Their Spatial and Temporal Fluctuations
Features:
• Presents original research in a wider perspective to reveal potential for synergies between the two fields of study
• Provides the latest experiments in primary literature for the modeling audience
• Includes chapters written by experts in systems biology and epigenetics who have vast experience studying clinical applications
Author
Leonie Ringrose, Professor at the IRI Lifesciences, Humboldt University, Berlin
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