EQUINE LAMINITIS

Contributors, vii
Foreword, x
Abbreviations, xii
• Part 1: Overview: From Basic Research to Caring for the Laminitis Patient
1 Historical Perspective on Equine Laminitis, 3
2 Laminitis: An Overview, 11
3 Anatomy and Function of the Equine Digit, 13
4 Lamellar Function at the Cellular Level, 22
5 Digital Biomechanics Relevant to Laminitis, 39
• Part 2: Pathophysiology of Laminitis
6 Overview, 51
7 Experimental Models of Laminitis: Starch Overload, 54
8 Experimental Models of Laminitis: Oligofructose Overload, 59
9 Experimental Models of Laminitis: BlackWalnut Extract, 64
10 Experimental Models of Laminitis: Hyperinsulinemia, 68
11 Hemodynamic Events in Laminitis, 75
12 The Role of Thrombosis and Coagulation in Equine Laminitis, 82
13 Leukocytes and Inflammatory Signaling in Laminitis: Leukocytes, 91
14 Leukocytes and Inflammatory Signaling in Laminitis: Inflammatory Signaling, 102
15 Role of Proteases in Laminitis, 115
16 Endocrine and Metabolic Dysregulation in Laminitis: Role of Pituitary Dysfunction, 134
17 Endocrine and Metabolic Dysregulation in Laminitis: Role of Corticosteroids, 141
18 Metabolic Syndrome in Humans and Horses: The Relationship Between Obesity and Insulin Resistance, 149
19 Dysregulation of the Lamellar Basal Epithelial Cell in Laminitis: Role of the Cytoskeleton and Cell Junctions, 167
20 Structural Dynamics of Displacement of the Distal Phalanx, 176
• Part 3: Clinical Presentation of Equine Laminitis
21 General Clinical Aspects of the Laminitis Case, 183
22 Sepsis-Related Laminitis, 191
23 Laminitis in Equine Metabolic Syndrome, 196
24 Laminitis in Pituitary Pars Intermedia Dysfunction, 204
25 Supporting Limb Laminitis, 210
• Part 4: Diagnostic Evaluation of Equine Laminitis
26 Detailed Physical Examination for Laminitis, 217
27 Diagnostic Imaging, 226
28 The Digital Venogram, 240
29 Endocrine and Metabolic Evaluation in Horses with Laminitis, 252
• Part 5: Medical Treatment of the Laminitic Patient
30 General Supportive Care for the Laminitis Case, 269
31 Common Therapies: Anti-Inflammatory Therapy, 277
32 Vasoactive Drug Therapy, 284
33 Analgesia, 291
34 Digital Hypothermia, 306
35 Equine Sepsis, 316
36 Equine Metabolic Syndrome, 329
37 Pituitary Pars Intermedia Dysfunction, 334
• Part 6: Treatment of Laminitis: Digital Support and Stabilization of the Distal Phalanx
38 Therapeutic Shoes: Application of Principles, 343
39 Solear Support Techniques, 354
40 Approaching Digital Management Prior to Displacement of the Distal Phalanx, 360
41 Hoof Care Management of Horses with Displacement of the Distal Phalanx, 364
• Part 7: Treatment of the Laminitis Case
42 The Use of Casts in Equine Laminitis, 377
43 Deep Digital Flexor Tenotomy, 382
44 Dorsal HoofWall Techniques, 391
45 Complications of Laminitis, 402
• Part 8: Management of Chronic Laminitis
46 Management Changes in the Laminitis Case, 413
• Part 9: Prevention of Laminitis
47 Overview of Laminitis Prevention, 423
48 Prevention of Supporting Limb Laminitis, 427
49 Prevention of Sepsis-Related Laminitis, 432
50 Nutritional Management for Avoidance of Pasture-Associated Laminitis, 436

Glossary, 442
Index, 445

The first book dedicated to this common, serious, and complex equine disease, Equine Laminitis is the gold-standard reference to the latest information on every aspect of the disease and its treatment.

Features
• Provides the first book devoted specifically to equine laminitis
• Discusses the current state of knowledge on all aspects of the disease, including its history, relevant anatomical considerations, pathophysiology, the diagnostic workup, and clinical treatment
• Presents 50 chapters written by leading international experts, under the editorship of the foremost authority on equine laminitis
• Offers a thorough understanding of this common affliction, grounded in the scientific literature
• Describes effective prevention and treatment plans

Author
James K. Belknap, DVM, PhD, Diplomate ACVS, is Professor of Equine Surgery in the Department of Veterinary Clinical Sciences at Ohio State University in Columbus, Ohio, USA. He runs a research laboratory studying the pathophysiology of equine laminitis, and works closely with the Certified Journeyman Farrier, Todd Adams, on podiatry cases including equine laminitis cases.