ETIOLOGY AND MORPHOGENESIS OF CONGENITAL HEART DISEASE

Part I. Reprogramming Approaches
• Reprogramming Approaches to Cardiovascular Disease
• Cell Sheet Tissue Engineering for Heart Failure
• The epicardium in development, disease and repair
• Congenital heart defects: in search of remediable etiologies
Part II. Early heart development I: Left-right axis and heterotaxy
• Human Heterotaxy Syndrome
• from Molecular Genetics to Clinical Features, Managements, and Prognosis
• Generating and sensing fluid flow by cilia during left-right patterning
• Role of the cilia in left-right patterning and congenital heart disease
• The heterotaxy gene, GALNT11, glycosylates Notch to orchestrate cilia type and laterality
Part III. Myocardial development
• Intercellular signaling in cardiac development and disease
• The Epicardium in Ventricular Septation during Evolution and Development
Part IV. Vessels: Coronary artery and Ductus
• Vascular development and disease. Multiple roles of extracellular matrix
• The preotic neural crest: A novel origin of coronary artery smooth muscle
• Progerin expression during normal closure of the human ductus arteriosus: A case of premature ageing?
• The multiple roles of prostagrandin E and oxygen in the regulation of the ductus arteriosus
Part V. Development of cardiac valves and valvular diseases
• Atrioventricular valve abnormalities
• From molecular mechanisms of morphogenesis to clinical perspective
• Molecular mechanisms of heart valve development and disease
• A novel role for endocardium in perinatal valve development: Lessons learned from tissue specific gene deletion of the Tie1 receptor tyrosine kinase
• The role of the epicardium in the formation of the cardiac valves
Part VI. Conduction system and arrhythmia
• Regulation of vertebrate conduction system development
• Cardiac Pacemaker Cells Originate within a Newly Defined Heart Field via Wnt Signaling
• Mediated Cell Fate Specification
Part VII. Gene regulation and epigenetics in cardiovascular development
• Heart cells survival by defined factors
• Pcgf5 forms a PRC1 (Polycomb repressive complex 1) in cardiac development
• Micro RNAs in heart development and disease
Part VIII. Stem cell development and regeneration
• Single-Cell Expression Analyses of embryonic cardiac progenitor cells
• Meis1 regulates post-natal cardiomyocyte cell cycle arrest
• Human pluripotent stem cells to model childhood heart disease
• Engineered cardiac tissues generated from immature cardiac and stem-cell derived cells: Multiple approaches and outcomes
• Future treatment of the heart failure and pathophysiological analysis of various heart diseases using human iPS cellderived cardiomyocytes
Part IX. Early heart development II: Second heart field
• Properties of the murine second heart field
• MEF2C regulates expression of Nodal signaling components in the outflow tract and is required for proper alignment of the aorta and pulmonary artery (Brian Black)
• Controlling the dynamics of differentiation: regulation of cardiac outflow tract assembly by Cadm4
• Smad4-independent requirement for BMPR1A signaling in cardiac outflow tract and right ventricle development
Part X. Cardiac outflow tract & Takao (22q11.2 deletion) syndrome
• A history and interaction of outflow progenitor cells implicated in TAKAO syndrome
• Tbx1: Mechanisms of action and strategies for phenotypic rescue
• The“ cardiac neural crest” concept revisited
Part XI. Genetics in cardiovascular development and diseases
• Deletion of ETS-1, a gene in the Jacobsen syndrome (11q-) cardiac critical region, causes congenital heart defects through a cardiac neural crest cell migration defect
• Notch signaling in aortic valve development and disease
• Genetic discovery for congenital heart disease In addition, short 30 chapters by Poster presenter shall be included.

• Focuses on the etiology and morphogenesis of congenital heart disease
• Includes contributions by an international group of distinguished scientists and clinicians
• Highlights the latest research topics and techniques and includes chapters dedicated to clinical implications and future directions

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.