EVIDENCE-BASED PRACTICE OF CRITICAL CARE, 2ND EDITION

•Critical Care & Critical Illness
1 Introduction: Critical Care Versus Critical Illness
2 What lessons have Intensivists learned during the Evidence Based Medicine Era?
3 Have outcomes in the critically ill improved? What factors are involved?
4 What are the long-term sequelae of critical illness?
5 Do early warning scores and rapid response teams improve outcomes?
•Basic Respiratory Management
6 What Are the Indications for Intubating the Critically Ill Patient?
7 Is the Role of Noninvasive Ventilation in the Intensive Care Unit?
8 How Does One Evaluate and Monitor Respiratory Function in the Intensive Care Unit?
9 "What Is the Optimal Approach to Weaning and Liberation from Mechanical Ventilation?"
10 Do ventilators damage lungs? How? What can be done to minimize it?
11 Is Extracorporeal Life Support for Adults with Acute Respiratory Distress Syndrome Useful?
12 What factors pre-dispose patients to lung injury ?
•Hemodynamic Management
13 What is the role of invasive hemodynamic monitoring in critical care?
14 Does the use of echocardiography aid in the management of the critically ill
15 How do I manage hemodynamic decompensation in a critically ill patient?
16 What tools or techniques are most useful to optimize fluid resuscitation?
•General Critical Care Management
17 What strategies can be used to optimize antibiotic use in the critically ill?
18 Is Prophylaxis for Stress Ulceration necessary?
19 Should fever be treated?
20 What fluids should I give to the critically ill patient? What fluids should I avoid?
21 How tightly should Blood Glucose Be Controlled in the Intensive Care Unit?
22 What are the potential applications of Hypothermia in Critically Ill Patients? Do they work?
23 What Are the Special Considerations in the Management of Morbidly Obese Patients in the Intensive Care Unit?
24 How Do I Transport the Critically Ill Patient?
25 Are computerized algorithms useful in managing the critically ill patient?
•Non ARDS, Non-Infectious Respir Disorders
26 How Should Pulmonary Embolism Be Diagnosed and Treated?
27 Should Exacerbations of COPD Be Managed in the Intensive Care Unit?
•ARDS
28 What is the Clinical Definition of ARDS?
29 What Are the Pathologic and Pathophysiologic Changes That Accompany Acute Lung Injury and ARDS?
30 What Is the Best Mechanical Ventilation Strategy in ARDS?
31 Is Permissive Hypercapnia Useful in ARDS?
32 "Do Patient Positioning in General and Prone Positioning in Particular Make a Difference in ARDS?"
33 Is Pulmonary Hypertension Important in ARDS ? Should We Treat It?
34 Do Inhaled Vasodilators Make a Difference in ARDS ?
35 Do Nonventilatory Strategies for Acute Lung Injury and ARDS Work?
36 Are Anti-Inflammatory Therapies in ARDS Effective?
•SEPSIS
37 What are Sepsis, MODS and Persistent Critical Illness (new definitions)?
38 Is there Immune Suppression in Sepsis?
39 What Is the Role of Empirical Antibiotic Therapy in Sepsis?
40 What is the appropriate blood pressure for a septic patient?
41 What Vasopressor Agent Should Be Used in the Septic Patient?
42 What Is the Role of Source Control in Sepsis?
43 How can we monitor the microcirculation in sepsis? Does it improve outcome?
44 Do the Surviving Sepsis Campaign Guidelines work?
45 Has outcome in sepsis improved? What has worked? What has not worked?
46 How do I Diagnose and Manage Catheter-Related Blood Stream Infections?
47 Is Selective Decontamination of the Digestive Tract Useful?
•Persistent Critical Illness
48 Is Persistent Critical Illness an Iatrogenic Disorder?
49 What is the Role of Autonomic Dysfunction in Critical Illness?
50 Does Persistent Critical Illness a result of mitochondrial dysfunction?
•Cardiovascular Critical Care
51 How do I manage acute heart failure?
52 How is Cardiogenic Shock Diagnosed and Managed in the Intensive Care Unit?
53 Is Hypertension a True Crisis and How Should It Be Managed in the Intensive Care Unit?
54 How Does One Manage and Treat Atrial Fibrillation in Postoperative Critically Ill Patients?
55 Is Right Ventricular Failure Common in the Intensive Care Unit? How Should It Be Managed?
•Kidney Injury & Critical Illness
56 How does one rapidly and correctly identify acute kidney injury?
57 What is the value of non-dialytic therapy in acute kidney injury?
58 How Does One Optimize Care in Patients at Risk for or Presenting with Acute Kidney Injury?
59 What Is the Role of Renal Replacement Therapy in the Intensive Care Unit?
•Metabolic Abnormalities in Critical Illness
60 How Should Acid-Base Disorders Be Diagnosed and Managed?
61 What is the Meaning of a High Lactate? What are the Implications of Lactic Acidosis?
62 How does critical illness alter metabolism?
•Neurological Critical Care
63 Is it really necessary to measure intracranial pressure in brain injured patients?
64 How Should Traumatic Brain Injury Be Managed?
65 How Should Aneurysmal Subarachnoid Hemorrhage Be Managed?
66 How should Acute Ischemic Stroke be managed in the Intensive Care Unit?
67 How should status epilepticus be managed in the ICU?
68 How should Guillain Barre Syndrome be Managed in the ICU?
•Nutrition, Gastrointestinal & Hepatic Critical Care
69 Is It Appropriate to Underfeed the Critically Ill Patient?
70 How does critical illness alter the liver?
71 How Is Acute Liver Failure Managed (Including Hepatic Encephalopathy)?
72 How does critical illness alter the gut? What can be done?
•Endocrine Critical Care
73 Is there a place for anabolic hormones in critical care?
74 How do I Diagnose and Manage Acute Endocrine Emergencies in the ICU?
•Preventing Suffering In the ICU
75 How Does One Diagnose, Treat, and Reduce Delirium in the Intensive Care Unit?
•Trauma, Obstetrics & Environmental Injuries
76 How Should Trauma Patients Be Managed in the Intensive Care Unit?
77 What Is Abdominal Compartment Syndrome and How Should It Be Managed?
78 How Should Patients with Burns Be Managed in the Intensive Care Unit?
79 What Is the Best Approach to Fluid Management, Transfusion Therapy, and the End Points of Resuscitation in Trauma?
80 How Should the Critically Ill Pregnant Patient Be Managed?
81 How Are Patients Who Are Admitted to the Intensive Care Unit after Common Poisonings Diagnosed and Managed?,
82 How should acute spinal cord injury be managed in the ICU?
•Hematology Critical Care
83 When Is Transfusion Therapy Indicated in Critically Ill Surgical Patients ?
84 What anticoagulants should be used in the critically ill? How do I choose?
•Critical Care Resource Use and Management
85 Are ICU resources under-used? Over-used? What is needed? What should be eliminated?
86 Does ICU admission improve the quality of care ?
87 Do guidelines or bundles improve outcomes in the critically ill? Pro & Con
88 How should care within an ICU or an institution be organized?
89 What is the role of Advance Practice Nurses and Physicians Assistants in the ICU?
•Critical Care Ethics
90 When is ICU Care Innovative Therapy and When Is It Clinical Research?
91 What factor's influence a family to support a decision to withdraw life support?

Evidence-Based Practice of Critical Care, 2nd Edition, presents objective data and expert guidance on managing critically ill patients in unique question-based chapters that focus on best practices. Now thoroughly updated by Drs. Clifford S. Deutschman, Patrick J. Neligan, and nearly 200 critical-care experts, this highly regarded title remains the only book of its kind that provides a comprehensive framework for translating evidence into practice, making it a valuable resource for both residents and practitioners.

Features:
•Tap into the expertise of nearly 200 critical-care experts who discuss the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence.
•Think through each question in a logical, efficient manner, using a practical, consistent approach to available management options and guidelines.
•Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches.
•Navigate a full range of challenges from routine care to complicated and special situations.

New To This Edition:
•Stay up to date with new issues and controversies such as the redefinition of sepsis • changing approaches to fluid administration • immune suppression in sepsis • monitoring the microcirculation • the long-term sequelae of critical illness • minimizing ventilator associated lung injury • the benefits of evidence-based medicine management guidelines • rapid response teams • and more.
•Benefit from all-new sections covering persistent critical illness and the role of advanced practice nurses and physician assistants in the ICU.

Authors
•Clifford S. Deutschman, MS, MD, FCCM, Vice Chair, Research, Pediatrics, Professor of Pediatrics and Molecular Medicine Hofstra-North Shore-LIJ School of Medicine, Cohen Children¹s Medical Center, New Hyde Park, NY.
•Patrick J. Neligan, MA, MB, FRCARCSI, Department of Anaesthesia & Intensive Care, University College Galway, Galway, Ireland