FENNER AND WHITE'S MEDICAL VIROLOGY. 5TH EDITION

• Part I: Principles of Virology
o Chapter 1. History and Impact of Virology
? Abstract
? Why Study Virology?
? A Brief History of Virology
? The Virosphere
? The Nature of Viruses
? Scope of This Book
? Further Reading
o Chapter 2. Classification of Viruses and Phylogenetic Relationships
? Abstract
? Viral Taxonomy
? Viral Nomenclature
? Groupings of Viruses on the Basis of Epidemiological Criteria
? Taxonomy and the Causal Relationship between Virus and Disease
? Genome Sequencing and Virus Evolution
? Further Reading
o Chapter 3. Virion Structure and Composition
? Abstract
? Physical Methods for Studying Virus Structure
? Chemical Composition of Virions
? Virion Symmetry
? Further Reading
o Chapter 4. Virus Replication
? Abstract
? Growth of Viruses
? The Virus Replication Cycle
? Satellite Viruses and Viroids
? Generation of Genetic Diversity
? Quantitative Virus Assays
? Defective Interfering Viruses
? Further Reading
o Chapter 5. Innate Immunity
? Abstract
? Innate Responses
? Monocytes, Macrophages, and Dendritic Cells
? The Role of Natural Killer (NK) Cells and the Link with Adaptive Immunity
? The Importance of Molecular Recognition
? Interferons
? Cell Death and Apoptosis
? Evasion Strategies
? Further Reading
o Chapter 6. Adaptive Immune Responses to Infection
? Abstract
? Overview of the Adaptive Immune Responses to Viral Infection
? The Major Histocompatibility Complex (MHC) and Antigen Presentation
? Antibodies
? Cytokines
? Recovery from Viral Infection
? Neutralization of Viral Infectivity by Antibodies
? Immunity to Reinfection
? Immunological Memory
? Further Reading
o Chapter 7. Pathogenesis of Virus Infections
? Abstract
? The Incoming Virus Inoculum
? Routes of Entry—A Major Factor Governing the Specific Pattern of Infection
? Mechanisms of Virus Spread Within the Body
? Virus Infection of Target Organs
? Persistent Virus Infections—Mechanisms Influencing Persistence
? Mechanisms of Disease Production
? Viruses and Immunosuppression
? Viral Virulence and Host Resistance to Infection
? Co-infections
? Further Reading
o Chapter 8. Patterns of Infection
? Abstract
? Transient Localized Infections
? Transient Systemic Infections
? Persistent Infections
? Persistent Localized Infections
? Persistent Systemic Infections
? Further Reading
o Chapter 9. Mechanisms of Viral Oncogenesis
? Abstract
? Definitions and Overview of Virus Transformation
? Oncogenes and Tumor Suppressor Genes
? Oncogenesis by Retroviruses
? Oncogenesis by Small DNA Viruses
? Oncogenesis by Large DNA Viruses
? Other Important Viruses Associated with Cancers
? The Prevention and Management of Virally Induced Tumors
? Further Reading
o Chapter 10. Laboratory Diagnosis of Virus Diseases
? Abstract
? Rationale for Performing Laboratory Virus Diagnosis
? Collection, Packaging, and Transport of Samples
? Direct Identification of Virus, Viral Antigen, or Viral Genome
? Virus Isolation
? Measurement of Serum Antibodies
? Interpretation of Laboratory Results
? Laboratory Safety
? Further Reading
o Chapter 11. Vaccines and Vaccination
? Abstract
? Vaccine Design and Production
? Vaccine Safety, Efficacy, and Practical Usage
? Factors Affecting Vaccine Safety
? Passive Protection
? Vaccination Policy and Programs
? Further Reading
o Chapter 12. Antiviral Chemotherapy
? Abstract
? Strategies for the Development of AntiViral Agents
? Clinical Application
? Clinical Strategies
? Mechanisms of Action and Role of Individual AntiViral Drugs
? Newer Approaches Under Development
? Further Reading
o Chapter 13. Epidemiology of Viral Infections
? Abstract
? Mechanisms of Virus Survival
? Viral Shedding and Routes of Transmission
? Factors Affecting the Dynamics of Viral Infections
? Epidemiological Investigations
? Mathematical Modeling
? Further Reading
o Chapter 14. Control, Prevention, and Eradication
? Abstract
? Surveillance and Modeling of Virus Diseases
? Measures to Minimize Transmission
? Immunization
? Eradication
? Bioterrorism
? Further Reading
o Chapter 15. Emerging Virus Diseases
? Abstract
? Increased Recognition and Changes in Disease Patterns
? Factors Affecting Emergence
? Climate Change
? Ease of Travel
? Animals as a Source of Human Diseases
? Prevention and Control
? Further Reading
• Part II: Specific Virus Diseases of Humans
o Chapter 16. Poxviruses
? Abstract
? Properties of Poxviruses
? Diseases Caused by Members of the Genus Orthopoxvirus
? Diseases Caused by Members of the Genus Molluscipoxvirus
? Diseases Caused by Members of the Genus Yatapoxvirus
? Diseases Caused by Members of the Genus Parapoxvirus
? Further Reading
o Chapter 17. Herpesviruses
? Abstract
? Properties of the Viruses
? Herpes Simplex Virus Infection
? Varicella-Zoster Virus Infection
? Cytomegalovirus Infection
? Human Herpesviruses 6 and 7 (HHV-6 and HHV-7) Infection
? Epstein-Barr Virus Infection
? Human Herpesvirus 8 (HHV-8: Kaposi’s Sarcoma-Associated Herpesvirus) Infection
? B Virus (Macacine Herpesvirus 1) Infection
? Further Reading
o Chapter 18. Adenoviruses
? Abstract
? Classification
? Properties of Adenoviruses
? Virus Replication
? Adenovirus Diseases
? Pathogenesis, Pathology, and Immunity
? Laboratory Diagnosis
? Epidemiology, Prevention, Control, Treatment
? Adenoviruses as Vectors for the Delivery of Heterologous DNA
? Further Reading
o Chapter 19. Papillomaviruses
? Abstract
? Classification
? Properties of Papillomaviruses
? Viral Replication
? Clinical Features
? Pathogenesis and Immunity
? Natural History of Genital HPV Infection
? Laboratory Diagnosis
? Epidemiology
? Treatment and Prevention
? Further Reading
o Chapter 20. Polyomaviruses
? Abstract
? Classification, Properties, and Replication
? Pathogenesis
? BK Polyomavirus
? JC Polyomavirus
? Other Recently Described Human Polyomaviruses
? Further Reading
o Chapter 21. Parvoviruses
? Abstract
? Classification
? Properties of Parvoviridae
? Viral Replication
? Parvovirus B19
? Pathogenesis and Immunity
? Clinical Features
? Transient Aplastic Crisis
? Other Complications of Parvovirus B19 Infection
? Laboratory Diagnosis
? Epidemiology
? Treatment and Control
? Dependoviruses
? Human Bocaviruses
? Further Reading
o Chapter 22. Hepatitis B and Hepatitis Delta Viruses
? Abstract
? Hepatitis B Virus
? Hepatitis Delta Virus
? Classification
? Virion Properties
? Viral Replication
? Clinical Features
? Pathogenesis
? Laboratory Diagnosis
? Epidemiology
? Treatment and Prevention
? Further Reading
o Chapter 23. Retroviruses
? Abstract
? Properties of Retroviridae
? Viral Replication
? Human T cell Lymphotropic Viruses
? Human Immunodeficiency Viruses
? Subfamily Spumavirinae
? Further Reading
o Chapter 24. Reoviruses
? Abstract
? Properties of Reoviruses
? Viral Replication
? Rotavirus Gastroenteritis
? Orbiviruses
? Coltiviruses
? Orthoreoviruses
? Further Reading
o Chapter 25. Orthomyxoviruses
? Abstract
? Properties of Orthomyxoviruses
? Influenza
? Further Reading
o Chapter 26. Paramyxoviruses
? Abstract
? Properties of Paramyxoviruses
? Respiratory Syncytial Virus Infection
? Parainfluenza Virus Infections
? Human Metapneumovirus Infection
? Measles
? Mumps
? Henipavirus Infections
? Further Reading
o Chapter 27. Rhabdoviruses
? Abstract
? Properties of Rhabdoviruses
? Rabies
? Vesicular Stomatitis and Other Rhabdoviruses
? Further Reading
o Chapter 28. Filoviruses
? Abstract
? Properties of Bunyaviruses
? Ebola and Marburg Virus Disease (Ebola and Marburg Hemorrhagic Fever)
? Further Reading
o Chapter 29. Bunyaviruses
? Abstract
? Properties of Bunyaviruses
? Diseases Caused by Members of the Genus Orthobunyavirus
? Diseases Caused by Members of the Genus Phlebovirus
? Diseases Caused by Members of the Genus Nairovirus
? Diseases Caused by Members of the Genus Hantavirus
? Further Reading
o Chapter 30. Arenaviruses
? Abstract
? Properties of Arenaviruses
? Lymphocytic Choriomeningitis Virus Infection
? Lassa Fever
? Lujo Virus Infection
? South American Hemorrhagic Fevers
? Further Reading
o Chapter 31. Coronaviruses
? Abstract
? Properties of Coronaviruses
? Human Coronavirus Infections
? Severe Acute Respiratory Virus (SARS-CoV)
? Middle East Respiratory Virus (MERS-CoV)
? Further Reading
o Chapter 32. Picornaviruses
? Abstract
? Properties of Picornaviruses
? Poliomyelitis
? Enteroviruses A, B, C, D, and Parechoviruses
? Human Rhinoviruses A, B, and C
? Hepatitis A (HAV)
? Further Reading
o Chapter 33. Caliciviruses
? Abstract
? Classification
? Virion Properties
? Calicivirus (Norovirus and Sapovirus) Gastroenteritis
? Further Reading
o Chapter 34. Astroviruses
? Abstract
? Properties of Astroviruses
? Clinical Features
? Laboratory Diagnosis
? Epidemiology
? Prevention
? Further Reading
o Chapter 35. Togaviruses
? Abstract
? Properties of Togaviruses
? Diseases Caused by Members of the Genus Alphavirus
? Alphaviruses Causing Encephalitis—Eastern, Western, and Venezuelan Encephalitis
? Alphavirus Infections Marked by Fever, Rash, Myalgia, Arthralgia, and Arthritis
? Chikungunya
? Other Alphavirus Infections
? Disease Caused by the Rubivirus Rubella Virus
? Further Reading
o Chapter 36. Flaviviruses
? Abstract
? Properties of Flaviviruses
? Diseases Caused by Mosquito-Borne Member Viruses of the Genus Flavivirus
? Yellow Fever
? Dengue
? Zika Virus
? Japanese Encephalitis
? West Nile Virus Infection
? St. Louis Encephalitis
? Usutu Virus Infection
? Murray Valley (Australian) Encephalitis
? Rocio Virus Encephalitis
? Diseases Caused by Tick-Borne Members of the Genus Flavivirus
? Diseases Caused by Members of the Genus Hepacivirus
? Other Hepaciviruses
? Further Reading
o Chapter 37. Hepeviruses
? Abstract
? Classification and Properties of Hepatitis E Virus
? Viral Replication
? Clinical Features
? Pathology, Pathogenesis, and Immunity
? Laboratory Diagnosis
? Epidemiology, Prevention, Control, and Therapeutics
? Further Reading
o Chapter 38. Prions
? Abstract
? Properties of Prions
? Human Prion Diseases
? Diagnosis
? Treatment and Prevention
? Other Chronic Neurodegenerative Diseases
? Further Reading
o Chapter 39. Viral Syndromes
? Abstract
? The Human Virome
? Viral Diseases of the Respiratory Tract
? Viral Gastroenteritis
? Viral Diseases of the Central Nervous System
? Viral Skin Rashes
? Viral Hemorrhagic Fevers
? Viral Genitourinary Infections
? Viral Diseases of the Eye
? Viral Arthritis
? Viral Carditis
? Viral Hepatitis
? Viral Pancreatitis and Diabetes
? Chronic Fatigue Syndrome
? Congenital and Perinatal Viral Infections
? Viral Infections in Immunocompromised Patients
? Diseases of Unknown Etiology
? Further Reading
• Index

Features:
• Features updated and expanded coverage of pathogenesis and immunity
• Contains the latest laboratory diagnostic methods
• Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control

Authors
• Christopher J. Burrell, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia.
• Colin R. Howard, University of Birmingham, UK.
• Frederick A. Murphy, University of Texas Medical Branch, Galveston, TX, USA