FETAL AND NEONATAL PHYSIOLOGY. 2-VOLUME SET. 6TH EDITION

Volume 1
• Section I Genetics and Embryology
1 Basic Genetic Principles, 1
2 Epigenetics, 11
3 Basic Embryology, 23
4 Regulation of Embryogenesis, 38
5 The Extracellular Matrix in Development, 47
6 Angiogenesis, 54
7 Prenatal Diagnosis, 58
• Section II Placenta and Intrauterine Environment
8 Placental Development, 67
9 Regulation of the Placental Circulation, 80
10 Mechanisms of Transfer Across the Human Placenta, 89
11 Endocrine and Paracrine Function of the Human Placenta, 101
12 Intra-Amniotic Infection/Inflammation and the Fetal Inflammatory Response Syndrome, 111
13 Fetal Origins of Adult Disease: A Classic Hypothesis With New Relevance, 129
14 Placental Function in Intrauterine Growth Restriction, 137
• Section III Developmental Pharmacology
15 Basic Pharmacologic Principles, 150
16 Principles of Pharmacokinetics, 166
17 The Physiology of Placental Drug Disposition, 173
18 Pharmacogenomics, 187
19 Drug Distribution in Fetal Life, 194
20 Drug Transfer During Breastfeeding, 203
• Section IV Intrauterine and Postnatal Growth
21 Placental and Fetal Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction, 214
22 Endocrine Factors Affecting Neonatal Growth, 224
23 Human Milk Composition and Function in the Infant, 241
24 Physiology of Lactation, 249
• Section V Perinatal Iron, Mineral, and Vitamin Metabolism
25 Fetal and Neonatal Iron Metabolism, 257
26 Fetal and Neonatal Calcium, Phosphorus, and Magnesium Homeostasis, 265
27 Zinc in the Fetus and Neonate, 282
28 Vitamin A Metabolism in the Fetus and Neonate, 287
29 Vitamin E Nutrition in Pregnancy and the Newborn Infant, 295
30 Vitamin K Metabolism in the Fetus and Neonate, 303
• Section VI Lipid Metabolism
31 Maternal-Fetal Transfer of Lipid Metabolites, 311
32 Brown Adipose Tissue: Development and Function, 323
33 Lipids as an Energy Source for the Premature and Term Neonate, 332
34 Ketone Body Metabolism in the Neonate, 339
35 Long-Chain Polyunsaturated Fatty Acids in Neurodevelopment, 348
• Section VII Carbohydrate Metabolism
36 Glucose Metabolism in the Fetus and Newborn, and Methods for Its Investigation, 358
37 Oxygen Consumption and General Carbohydrate Metabolism of the Fetus, 368
38 Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period, 382
39 Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development, 392
• Section VIII Protein Metabolism
40 General Concepts of Protein Metabolism, 400
41 Placental Transfer and Fetal Requirements of Amino Acids, 408
• Section IX Thermoregulation
42 Temperature Control in Newborn Infants, 423
• Section X Skin
43 Structure and Development of the Skin and Cutaneous Appendages, 446
44 Physiologic Development of the Skin, 454
• Section XI Fetal and Neonatal Cardiovascular Physiology
45 Cardiovascular Development, 473
46 Developmental Electrophysiology in the Fetus and Neonate, 482
47 Developmental Biology of the Pulmonary Vasculature, 501
48 Development of the Gastrointestinal Circulation in the Fetus and Newborn, 517
49 Physiology of Congenital Heart Disease in the Neonate, 521
50 Regulation of Cardiovascular Function During Fetal and Newborn Life, 534
51 Nutritional and Environmental Effects on the Fetal Circulation, 545
52 Mechanisms Regulating Closure of the Ductus Arteriosus, 553
53 Umbilical Circulation, 564
54 Fetal and Placental Circulation During Labor, 576
• Section XII The Lung
55 Normal and Abnormal Structural Development of the Lung, 585
56 Regulation of Alveolarization, 600
57 Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth, 605
58 Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis, 617
59 Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung, 626
60 Upper Airway Structure: Function, Regulation, and Development, 635
61 Regulation of Lower Airway Function, 645
62 Functional Development of Respiratory Muscles, 652
63 Mechanics of Breathing, 665
64 Pulmonary Gas Exchange in the Developing Lung, 673
65 Oxygen Transport and Delivery, 684
66 Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate, 697
67 Basic Mechanisms of Oxygen Sensing and Adaptation to Hypoxia, 707
68 Evaluation of Pulmonary Function in the Neonate, 714
69 Mechanisms of Neonatal Lung Injury, 728
70 Impaired Lung Growth After Injury in Preterm Lung, 734
71 Antenatal Factors That Influence Postnatal Lung Development and Injury, 748
72 Regulation of Pulmonary Circulation, 757
• SECTION XIII Surfactant
73 Historical Perspective, 765
74 Developmental Biology of Lung Stem Cells, 768
75 Surfactant Homeostasis: Composition and Function of Pulmonary Surfactant Lipids and Proteins, 776
76 Structure and Development of Alveolar Epithelial Cells, 787
77 Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion, 792
78 Antenatal Hormonal Therapy for Prevention of Respiratory Distress Syndrome, 804
79 Surfactant Treatment, 813
80 Genetics and Physiology of Surfactant Protein Deficiencies, 825
• SECTION XIV Physiology of Gastrointestinal Tract in the Fetus and Neonate
81 Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development, 838
82 Organogenesis of the Gastrointestinal Tract, 845
83 Development of Gastric Secretory Function, 854
84 Development of the Enteric Nervous System and Gastrointestinal Motility, 859
85 Development of the Endocrine and Exocrine Pancreas, 868
86 Digestive-Absorptive Functions in Fetuses, Infants, and Children, 881
87 The Developing Microbiome of the Fetus and Neonate: A Multiomic Approach, 888
• SECTION XV Liver and Bilirubin Metabolism
88 Organogenesis and Histologic Development of the Liver, 896
89 Bile Acid Metabolism During Development, 901
90 Fetal and Neonatal Bilirubin Metabolism, 915
91 Hereditary Contributions to Neonatal Hyperbilirubinemia, 919
92 Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia, 930

Volume 2
• Section XVI The Kidney
93 Development of the Kidney: Morphology and Mechanisms, 941
94 Functional Development of the Kidney in Utero, 954
95 Development and Regulation of Renal Blood Flow in the Neonate, 965
96 Postnatal Development of Glomerular Filtration Rate in Neonates, 975
97 Renal Transport of Sodium During Development, 984
98 Potassium Homeostasis in the Fetus and Neonate, 992
99 Role of the Kidney in Calcium and Phosphorus Homeostasis, 1006
100 Transport of Amino Acids in the Fetus and Neonate, 1018
101 Organic Anion Transport in the Developing Kidney, 1024
102 Concentration and Dilution of Urine, 1030
103 Urinary Acidification, 1047
104 Response to Nephron Loss in Early Development, 1056
• SECTION XVII Fluid and Electrolyte Metabolism
105 Fluid Distribution in the Fetus and Neonate, 1064
106 Regulation of Acid-Base Balance in the Fetus and Neonate, 1076
• Section XVIII Developmental Hematopoiesis
107 Developmental Biology of Hematopoietic Stem Cells, 1082
108 Neutrophil Granulopoiesis and Homeostasis, 1093
109 Developmental Erythropoiesis, 1104
110 Developmental Megakaryopoiesis, 1125
• Section XIX Hemostasis
111 Developmental Hemostasis, 1145
112 Platelet–Vessel Wall Interactions, 1153
• Section XX Developmental Immunobiology
113 Host Defense Mechanisms Against Bacteria, 1158
114 Host Defense Mechanisms Against Fungi, 1167
115 Host Defense Mechanisms Against Viruses, 1172
116 T-Cell Development, 1195
117 B-Cell Development, 1200
118 Mononuclear Phagocyte System, 1206
119 Normal and Abnormal Neutrophil Physiology in the Newborn, 1215
120 The Complement System of the Fetus and Newborn, 1232
121 Cytokines and Inflammatory Response in the Fetus and Neonate, 1243
122 Immunology of Human Milk, 1257
123 Neonatal Pulmonary Host Defense, 1265
• Section XXI Neurology
124 Development of the Nervous System, 1297
125 Mechanisms of Cell Death in the Developing Brain, 1318
126 Development of the Blood-Brain Barrier, 1327
127 Trophic Factor, Nutritional, and Hormonal Regulation of Brain Development, 1341
128 Developmental Aspects of Pain, 1347
129 Cerebellar Development—The Impact of Preterm Birth and Comorbidities, 1353
130 Electroencephalography in the Preterm and Term Infant, 1367
131 Intraventricular Hemorrhage in the Neonate, 1394
132 Pathophysiology of Neonatal White Matter Injury, 1414
133 Cellular and Molecular Mechanisms of Neonatal Brain Injury and Neuroprotection, 1422
134 Neuroprotective Therapeutic Hypothermia, 1432
• Section XXII Special Sensory Systems in the Fetus and Neonate
135 Early Development of the Human Auditory System, 1440
136 Development of Olfaction and Taste in the Human Fetus and Neonate, 1455
• Section XXIII Musculoskeletal
137 The Growth Plate: Embryologic Origin, Structure, and Function, 1465
138 Ontogenesis of Striated Muscle, 1475
• Section XXIV Endocrine Function
139 Hypothalamus: Neuroendometabolic Center, 1495
140 Growth Factor Regulation of Fetal Growth, 1505
141 Growth Hormone, Prolactin, and Placental Lactogen in the Fetus and Newborn, 1514
142 Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant, 1520
143 Development of the Hypothalamus-Pituitary-Adrenal Axis in the Fetus, 1532
144 Fetal and Neonatal Adrenocortical Physiology, 1538
145 Fetal and Neonatal Thyroid Physiology, 1546
• Section XXV Ovary and Testis
146 Genetics of Sex Determination and Differentiation, 1555
147 Differentiation of the Ovary, 1566
148 Testicular Development and Descent, 1574
• Section XXVI PAT HOPHYSIOLOGY OF NEONATAL DISEASES
149 The Pathophysiology of Twin-Twin Transfusion Syndrome, Twin-Anemia Polycythemia Sequence, and Twin-Reversed Arterial Perfusion, 1582
150 Physiology of Neonatal Resuscitation, 1589
151 Pathophysiology of Neonatal Sepsis, 1606
152 Pathophysiology of Neonatal Hypoglycemia, 1624
153 Pathophysiology of Cardiomyopathies, 1633
154 Pathophysiology of Persistent Pulmonary Hypertension of the Newborn, 1648
155 Pathophysiology of Shock in the Fetus and Neonate, 1662
156 Pathophysiology of Apnea of Prematurity, 1671
157 Pathophysiology of Respiratory Distress Syndrome, 1680
158 Pathophysiology of Meconium Aspiration Syndrome, 1696
159 Pathophysiology of Bronchopulmonary Dysplasia, 1703
160 Pathophysiology of Ventilator-Dependent Infants, 1710
161 Pathophysiology of Gastroesophageal Reflux, 1722
162 Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis, 1732
163 Pathophysiology of Kernicterus, 1738
164 Pathophysiology of Neonatal Acute Kidney Injury, 1750
165 Pathophysiology of Edema, 1760
166 Pathophysiology of Retinopathy of Prematurity, 1765
167 Pathophysiology of Neonatal Hypoxic-Ischemic Brain Injury, 1773
168 Pathophysiology of Neonatal Acute Bacterial Meningitis, 1784
169 Pathophysiology of Neural Tube Defects, 1797
170 Pathophysiology of Preeclampsia, 1811
171 Pathophysiology of Preterm Birth, 1820
172 Pathophysiology of Chorioamnionitis: Host Immunity and Microbial Virulence, 1828
173 Pathophysiology of Genetic Neonatal Disease, 1837
174 Genetic Variants and Neonatal Disease, 1846

Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today’s busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice. It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application.

Authors
• Richard A. Polin, MD, William T. Speck Professor of Pediatrics, College of Physicians and Surgeons, Columbia University; Director, Division of Neonatology, Morgan Stanley Children's Hospital of New York - Presbyterian, Columbia University Medical Center, New York, New York.
• Steven H. Abman, MD, Professor of Pediatrics, University of Colorado School of Medicine; Director, Pediatric Heart Lung Center, Children’s Hospital Colorado, Denver, Colorado.
• David Rowitch, MD, PhD, Professor of Pediatrics and Neurosurgery, Chief, Division of Neonatology, UCSF Benioff Children’s Hospital San Francisco, San Francisco, California.
• William E. Benitz, MD, Professor Emeritus, Stanford University, Division of Neonatal Medicine, Stanford, California