FLUORESCENCE IMAGING FOR SURGEONS

Table of contents (37 chapter)
1.Basic Concepts of Fluorescence and Fluorescent Probes
2.Past, Present, and Future of Fluorescence
3.Translation of Therapeutic Antibodies for Intraoperative Fluorescence Imaging
4.Review of Indocyanine Green Imaging in Surgery
5.D-Light P System (Karl Storz)
6.Robotic Surgery Using Firefly System
7.Fluorescence Imaging Systems (PDE, HyperEye Medical System, and Prototypes in Japan)
8.The Pinpoint System
9.Economic Impact of Fluorescent Cholangiography
10.Real-Time Near-Infrared Fluorescent Cholangiography During Robotic Single-Site Cholecystectomy
11.Fluorescent-Guided Liver Surgery: Paul Brousse Experiences and Perspective
12.Fluorescence Imaging in Laparoscopic Hepatectomy
13.Identification of Hepatic Segment
14.Intraoperative Evaluation of Regional Portal Uptake Function
15.Identification of Hepatocellular Carcinoma
16.Identification of Malignant Tumors in the Liver
17.Prediction for Postoperative Intrahepatic Recurrence of Hepatocellular Carcinoma
18.Detection of Bile Leakage After Hepatic Resection by Intraoperative Indocyanine Green Fluorescent Imaging
19.Near-Infrared Laser Photodynamic Therapy for Human Hepatocellular Carcinoma Cell Line Tumor with Indocyanine Green Fluorescence
20.Photodynamic Diagnosis of Gastric Cancer Using 5-Aminolevulinic Acid
21.Applications of ICG Fluorescence Imaging for Surgery in Colorectal Cancers
22.Fluorophore-Conjugated Chimeric Anti-CEA Antibodies for Fluorescence-Guided Surgery of Gastrointestinal (GI) Tumors
23.Development of a Non-blurring, Dual-Imaging (X-Ray/Fluorescence) Tissue Marker for Localization of Gastrointestinal Tumors
24.Sentinel Node Navigation Surgery by Infrared Imaging in Gastric Cancer
25.A Dual Infrared Ray Imaging System for Sentinel Node Mapping Against Early Gastric Cancer: Absorption and Florescence Methods by Infrared Ray Laparoscopy System Combined with Indocyanine Green
26.Indocyanine Green Fluorescence-Navigated Sentinel Node Biopsy Showed Higher Sensitivity than the Conventional Radioisotope or Blue Dye Methods: It May Help to Reduce False-Negative Sentinel Lymph Node Biopsies in Skin Cancer
27.The Indocyanine Green Method Is Equivalent to the (99m) Tc-Labeled Radiotracer Method for Identifying the Sentinel Node in Breast Cancer: A Concordance and Validation Study
28.Photodynamic Detection of Lymph Node Metastases in Gastrointestinal Cancer by Using 5-Aminolevulinic Acid
29.Application of Photodynamic Treatment
30.Photodynamic Diagnosis Mediated by 5-Aminolevulinic Acid for Urinary Bladder Cancer
31.Real-Time Assessment of Intestinal Perfusion by Fluorescence-Based Enhanced Reality
32.Fluorescent Angiography for Flap Planning and Monitoring in Reconstructive Surgery
33.Fluorescein Detection of Myocardial Ischemia in an Experimental Model of Acute Coronary Occlusion
34.Spatial and Temporal Monitoring of Perfusion with Indocyanine Green Videoangiography in the Rat Heart
35.Ureter Identification Using Methylene Blue and Fluorescein
36.Chymotrypsin Probe for Real-Time Visualization of Pancreatic Leak
37.Miniaturized Clinical Imaging Device for Optical Surgery

This text presents the experiences of leading researchers and surgeons with different fluorescence methods. Chapters range from basic science of fluorescence to current clinical applications and new horizons. The first few chapters describe the historical evolution and physical principles of fluorescence and provide the foundation for the reader to understand the current scope and limits of its use in surgery. The second section focuses on the clinical applications of intraoperative fluorescence imaging including subsections on fluorescence cholangiography, applications to hepatectomy, lymph node navigation, applications to GI tract and pelvic surgery and identification of cancer tissues. The third section focuses on new frontiers including fluorescence probes, imaging systems and applications to photodynamic therapy.
Authored by leaders in the development of fluorescent methods worldwide, Fluorescence Imaging for Surgeons: Concepts and Applications will have an impact on numerous medical specialists including general surgeons, colorectal and minimally-invasive surgeons and surgical oncologists. Researchers will find the book to be an invaluable resource on the latest advances in the utilization of nanoparticles and fluorescent probes.

Authors
Fernando Dip, MD, MAAC
The Bariatric and Metabolic Institute
Section of Minimally Invasive Surgery
Department of General and Vascular Surgery
Cleveland Clinic Florida
Weston, FL
USA
And
Oncological Surgical Division, Department of Surgery
Division of Surgical Research
Hospital de Clinicas Buenos Aires
University of Buenos Aires
Buenos Aires, Argentina

Takeaki Ishizawa, MD, PhD, FACS
Department of Gastroenterological Surgery, Cancer Institute Hospital
Japanese Foundation for Cancer Reserach
Koto-ku, Tokyo
Japan
And
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery
Graduate School of Medicine, The University of Tokyo
Bunkyo-ky, Tokya
Japan

Norihiro Kokudo, MD, PhD, FACS
Professor and Chairman
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery
Graduate School of Medicine, The University of Tokyo
Bunkyo-ky, Tokya
Japan

Raul J. Rosenthal, MD, FACS
Chief of Staff
The Bariatric & Metabolic Institute
Section of Minimally Invasive Surgery
Department of General & Vascular Surgery
Cleveland Clinic Florida
Weston, FL USA