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• SECTION I. Clinical manifestations and disease detection
1. Primary prevention of colorectal cancer
2. Population-based universal screening for CRC. Secondary prevention
3. The role of primary care in early referral of CRC patients
4. Fast patient referral with suspected CRC
• SECTION II. Diagnosis and staging
5. Endoscopic diagnosis of colorectal cancer
6. Colon endoscopic capsule
7. Endoscopic ultrasound in colorectal cancer
8. Virtual colonoscopy. Colo-CT
9. Colorectal cancer staging: ultrasound and multislice CT
10. Applications of [18F] FDG PET and PET-CT in colorectal carcinoma
11. MRI of rectal adenocarcinoma
12. Molecular pathology of colorectal carcinoma
13. Anatomopathologic diagnosis of CRC
14. Colonoscopy. Technique and quality factors
15. Endoscopic diagnosis of preneoplastic and neoplastic lesions
• SECTION III. Treatment
16. Multidisciplinary committee for a comprehensive approach to colorectal cancer patients
Endoscopic treatment
17. Endoscopic treatment of preneoplastic or early lesions
18. Endoscopic monitoring
19. Advanced endoscopy in CRC. Colorectal prostheses
Surgical treatment
20.? Surgical Emergency in RCC
21.? Experimental surgery in RCC
22. Colon and rectal cancer surgery
23. Treatment of liver metastases in colorectal cancer
Pharmacological treatment and radiotherapy
24. Chemotherapy in advanced and metastatic disease
25. Adjuvant chemotherapy in colorectal cancer
26. Oral administration of cytostatic drugs for colorectal cancer treatment
27. Complementary and intraoperative neoadjuvant chemotherapy in rectal cancer
28. Immunology and immunotherapy in colorectal cancer
Anesthetic and postoperative management
29. Multimodal rehabilitation: optimizing pre and intraoperative surgery in colorectal cancer
30. Postoperative management: Complications and critical care unit management
31. Pain units: Symptom control
• SECTION IV. Molecular and biological mechanisms of CRC
32. The role of intestinal microbiota in the colorectal cancer
33. Genetic susceptibility to colorectal cancer and chemotherapy response
34. Stem cells and colon cancer
35. Signaling pathways in colon cancer
36. Colorrectal Cancer a Darwinian the Celular Inmune-Selection Model
37. Epithelial-mesenchymal transition and colorectal cáncer
• SECTION V. New diagnostic methods
38 Biomarkers
39. Bioinformatic tools for research in colorectal cancer
40. Omic-based Biomarkers for Colorectal Cancer
• SECTION VI. Biobanks
41. Regulations regarding the use of human biological samples for research
42. The role of biobanks in the study of colorectal carcinoma
• SECTION VII. Epidemiological studies in CRC
43. Incidence and mortality of colorectal cancer : an international and regional vision
44. Prognosis and follow-up of colorectal cancer patients. Role of diagnostic and therapeutic delay
• SECTION VIII. Hereditary colorectal cancer
45. Hereditary nonpolyposis colorectal cancer
46. Hereditary polyposis colorectal cáncer
• SECTION IX. Addressing the consequences of CRC
47. Addressing and psychologically controlling the disease
48. Ostomy care
49. Fecal incontinence and colorectal cancer
50. Ethical issues in CRC diagnosis and treatment
51. Sexuality in Ostomized Digestive Patients (Sexual Dysfunction in the Ostomized Patient)

• Provides a multidisciplinary approach with a holistic view of colorectal cancer, ranging from basic science to population studies, with its social and environmental influences and impacts, interpreting the disease as a medical, chemical, physical, microbial, psychological, and social condition
• Written by a diverse group of specialists with complementary expertise, including oncologists, radiologists, biochemists, surgeons, psychologists, social workers and clinicians, all members of the Galician Research Network of Colorectal Cancer (REGICC) with vast collaboration experience to bring comprehensive knowledge on the subject
• Encompasses reliable information suitable for different workers within the healthcare sector and research community dedicated to colorectal cancer, from clinicians and healthcare providers, researchers on several aspects of cancer, to bioinformaticians who deal with health data
• Includes many case studies throughout the chapters discussed by specialists with high scientific accuracy and didactic value, in order to clearly and precisely share their professional experience on the subject with readers

Alejandro Pazos Sierra , Full Professor, Faculty of Computer Science, University of A Coruna; Coordinator, Galician Research Network of Colorectal Cancer (REGICC), A Coruna, Galicia, Spain