FRAILTY AND SARCOPENIA IN CIRRHOSIS. THE BASICS, THE CHALLENGES, AND THE FUTURE

• Definition & Diagnosis of Sarcopenia in the Research and Clinical Settings
• The Definition and Diagnosis of Frailty in the Research and Clinical Settings
• Deciphering the Cirrhotic Patient’s Present Status: The Overlap between Physical Frailty, Disability and Sarcopenia
• The Pathogenesis of Physical Frailty and Sarcopenia
• Prognostic Implications of Physical Frailty and Sarcopenia Pre and Post Transplantation
• Nutritional Therapy in the Management of Physical Frailty and Sarcopenia
• Exercise Training in Patients with Cirrhosis
• Sex, Age and Ethnicity Dependent Variation in Body Composition: Can There Be a Single Cut-off?
• Muscle Mass versus Muscle Strength and Performance: Is Muscle Mass Measurement Alone Enough?
• The Role of Changes in Subcutaneous and Visceral Adiposity, Sarcopenic Obesity and Myosteatosis/Muscle Quality in Cirrhosis:How to Diagnose It and Its Contribution to Prognosis
• Evidence for the Assessment of Physical Frailty and Sarcopenia in Hospitalized Patients and the Role of Assessing Changes Over Time
• Frailty and Sarcopenia in the Selection of Candidates for Liver Transplantation
• Physical Frailty and Sarcopenia in End Stage Liver Disease: Do They Improve after Liver Transplantation?
• Measures of Sarcopenia: The Utility of Ultrasound, Bioelectrical Impedance Analysis, and Single-Slice Cross-Sectional Imaging
• Upcoming Pharmacological and Interventional Therapies for the Treatment of Physical Frailty and Sarcopenia
• Should Frailty Include Multidimensional and Dynamic Factors?
• Hepatic Encephalopathy, Sarcopenia and Frailty
• A Research Wish List to Understand, Diagnose and Manage Frailty and Sarcopenia.

This book provides a concise yet comprehensive overview of frailty and sarcopenia in the cirrhotic patient. The text presents a personalized approach to identifying cirrhotic patients at risk of higher morbidity and mortality due to frailty and sarcopenia. It reviews current and novel diagnostic methods, while spotlighting treatment and management strategies for frailty and sarcopenia. The book also focuses on special issues associated with these syndromes, such as the effect of gender, age, and ethnicity on frailty and sarcopenia, sarcopenic obesity, and frailty and sarcopenia after liver transplantation. Future considerations are outlined in the closing chapters, including emerging pharmacological and interventional therapies for these syndromes.

Written by experts in the field, Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future is a valuable resource for clinicians and practitioners who treat patients with cirrhosis.
Features
• One of the first dedicated texts on this emerging area of study in cirrhosis
• Features explanatory figures, algorithms, and summary tables for each chapter
• Written by experts in the field

Authors
• Puneeta Tandon, MDUniversity of AlbertaDepartment of MedicineDivision of Gastroenterology and Liver UnitEdmonton, Alberta Canada
• Aldo J. Montano-Loza, MDUniversity of AlbertaDepartment of MedicineDivision of Gastroenterology and Liver UnitEdmonton, AlbertaCanada