FRAILTY IN OLDER ADULTS WITH CANCER

• Introduction to frailty in older adults with cancer
• Global action and policies in older adults with cancer and frailty
• Frailty screening and comprehensive geriatric assessment
• Cognitive impairment in older adults with cancer and frailty
• Psychosocial dimension in older adults with cancer and frailty
• Comorbidity and polypharmacy in older adults with cancer and frailty
• Malnutrition, cachexia and sarcopenia in older adults with cancer and frailty
• Physical performance and functional status in older adults with cancer and frailty
• Prehabilitation and rehabilitation in older adults with cancer and frailty
• Holistic needs assessment and advance care planning in older adults with cancer and frailty
• Multidisciplinary onco-geriatric care models
• Decision-making process in older adults with cancer and frailty
• Perioperative care in older adults with cancer and frailty
• Radiotherapy and systemic anti-cancer treatment in older adults with cancer and frailty
• Palliative care in older adults with cancer and frailty
• Frailty research: the present and the future
• Breast cancer in older adults with frailty
• Non-small cell lung cancer in older adults with frailty
• Colorectal cancer in older adults with frailty
• Prostate cancer in older adults with frailty
• Renal cell carcinoma in older adults with frailty
• Cutaneous melanoma in older adults with frailty
• Gastroesophageal cancer in older adults with frailty
• Hepatopancreaticobiliary cancer in older adults with frailty
• Gynaecological cancer in older adults with frailty
• Head and neck cancer in older adults with frailty
• Hematological cancer in older adults with frailty.

This book summarizes evidence on frailty and ageing, how this may impact patient outcomes and how frailty can be assessed, managed and incorporated in the decision-making process for older patients with cancer. The book aims to: empower clinical teams to assess and support older cancer patients with frailty, ideally within a multidisciplinary setting; and to improve the selection of older cancer patients to the most appropriate management/treatment strategies in order to improve the outcomes of this group of patients often underrepresented in research. The reader will learn the methods available for assessing frailty, such as screening tools, but also how to perform different geriatric assessments covering the different key components (physical, nutritional, social, psychological, etc.). The book also provides information on how to manage and intervene on frailty with the role of pre-habilitation and re-habilitation, how to set-up specialised teams and pathways within one’s hospital and community for these older cancer patients with frailty. Finally, the management of this challenging group of patients according to the cancer type is discussed in detail, alongside with mapping the unmet research needs and future directions in this field.