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I. Pediatric Critical Care: The Discipline
1. History of Pediatric Critical Care Medicine
2. High-Reliability Pediatric Intensive Care Unit: Role of Intensivist and Team in Obtaining Optimal Outcomes
3. Critical Communications in the Pediatric Intensive Care Unit
4. Professionalism in Pediatric Critical Care
5. Leading and Managing Change in the Pediatric Intensive Care Unit
6. The Evolution of Critical Care Nursing
7. Fostering a Learning Health Care Environment in the Pediatric Intensive Care Unit
8. Challenges for Pediatric Critical Care in Resource-Poor Settings
9. Public Health Emergencies and Emergency Mass Critical Care
10. Lifelong Learning in Pediatric Critical Care
II. Pediatric Critical Care: Tools and Procedures
11. Essential Concepts in Clinical Trial Design and Statistical Analysis
12. Prediction Tools for Short-Term Outcomes Following Critical Illness in Children
13. Pediatric Transport
14. Pediatric Vascular Access and Centeses
15. Ultrasonography in the Pediatric Intensive Care Unit
III. Pediatric Critical Care: Psychosocial and Societal
16. Patient- and Family-Centered Care in the Pediatric Intensive Care Unit
17. Pediatric Critical Care Ethics
18. Ethical Issues Around Death and Dying
19. Palliative Care in the Pediatric Intensive Care Unit
20. Organ Donation Process and Management of the Organ Donor
21. Long-Term Outcomes following Critical Illness in Children
22. Burnout and Resiliency
IV. Pediatric Critical Care: Cardiovascular
23. Structure and Function of the Heart
24. Regional and Peripheral Circulation
25. Endothelium and Endotheliopathy
26. Principles of Invasive Cardiovascular Monitoring
27. Assessment of Cardiovascular Function
28. Cardiac Failure and Ventricular Assist Devices
29. Echocardiographic Imaging
30. Diagnostic and Therapeutic Cardiac Catheterization
31. Pharmacology of the Cardiovascular System
32. Cardiopulmonary Interactions
33. Disorders of Cardiac Rhythm
34. Shock States
35. Pediatric Cardiopulmonary Bypass
36. Critical Care After Surgery For Congenital Heart Disease
37. Pediatric Cardiac Transplantation
38. Physiologic Foundations of Cardiopulmonary Resuscitation
39. Performance of Cardiopulmonary Resuscitation in Infants and Children
V. Pediatric Critical Care: Pulmonary
40. Structure and Development of the Upper Respiratory System
41. Structure and Development of the Lower Respiratory System
42. Physiology of the Respiratory System
43. Noninvasive Respiratory Monitoring and Assessment of Gas Exchange
44. Overview of Breathing Failure
45. Ventilation/Perfusion Inequality
46. Mechanical Dysfunction of the Respiratory System
47. Diseases of the Upper Respiratory Tract
48. Pediatric Acute Respiratory Distress Syndrome and Ventilator-Associated Lung Injury
49. Acute Viral Bronchiolitis
50. Asthma
51. Neonatal Pulmonary Disease
52. Pneumonitis and Interstitial Disease
53. Diseases of the Pulmonary Circulation
54. Mechanical Ventilation and Respiratory Care
55. Noninvasive Ventilation in the Pediatric Intensive Care Unit
56. Extracorporeal Life Support
57. Pediatric Lung Transplantation
VI. Pediatric Critical Care: Neurological
58. Structure, Function, and Development of the Nervous System
59. Critical Care Considerations for Common Neurosurgical Conditions
60. Neurological Assessment and Monitoring
61. Neuroimaging
62. Coma and Depressed Sensorium
63. Intracranial Hypertension and Monitoring
64. Status Epilepticus
65. Anoxic Ischemic Encephalopathy
66. Pediatric Stroke and Intracerebral Hemorrhage
67. Central Nervous System Infections and Related Conditions
68. Acute Neuromuscular Disease and Disorders
69. Acute Rehabilitation and Early Mobility in the Pediatric ICU
VII. Pediatric Critical Care: Renal
70. Renal Structure and Function
71. Fluid and Electrolyte Issues in Pediatric Critical Illness
72. Acid-Base Balance in Critical Illness
73. Tests of Kidney Function in Children
74. Glomerular Tubular Dysfunction and AKI
75. Pediatric Renal Replacement Therapy in the Intensive Care Unit
76. Pediatric Renal Transplantation
77. Renal Pharmacology
78. Hypertensive Urgencies and Emergencies
VIII. Pediatric Critical Care: Metabolic and Endocrine
79. Cellular Respiration
80. Biology of the Stress Response
81. Inborn Errors of Metabolism
82. Genetic Variation in Health and Disease
83. Molecular Mechanisms of Cellular Injury
84. Endocrine Emergencies
85. Diabetic Ketoacidosis
IX. Pediatric Critical Care: Hematology and Oncology
86. Structure and Function of the Hematopoietic Organs
87. The Erythron
88. Hemoglobinopathies
89. Coagulation and Coagulopathy
90. Thrombosis in Pediatric Critical Care
91. Transfusion Medicine
92. Hematology and Oncology Problems
93. Critical Illness in Children Undergoing Hematopoietic Progenitor Cell Transplantation
X. Pediatric Critical Care: Gastroenterology and Nutrition
94. Gastrointestinal Structure and Function
95. Disorders of the Gastrointestinal System
96. Acute Liver Failure
97. Hepatic Transplantation
98. Acute Abdomen
99. Nutrition of the Critically Ill Child
XI. Pediatric Critical Care: Immunity and Infection
100. Innate Immunity
101. Adaptive Immunity
102. Critical Illness and the Microbiome
103. Congenital Immunodeficiency
104. Acquired Immune Dysfunction
105. Immune Balance in Critical Illness
106. Pediatric Rheumatic Disease
107. Bacterial and Fungal Infections
108. Life-Threatening Viral Diseases and Their Treatment
109. Healthcare-Associated Infections
110. Pediatric Sepsis
111. Multiple Organ Dysfunction Syndrome
XII. Pediatric Critical Care: Environmental Injury and Trauma
112. Bites and Stings
113. Hyperthermic Injury
114. Hypothermic Injury
115. Drowning
116. Burn and Inhalation Injury
117. Evaluation, Stabilization, and Initial Management after Trauma
118. Traumatic Brain Injury
119. Pediatric Thoracic Trauma
120. Pediatric Abdominal Trauma
121. Child Abuse
XIII. Pediatric Critical Care: Pharmacology and Toxicology
122. Principles of Drug Disposition
123. Molecular Mechanisms of Drug Action
124. Adverse Drug Reactions and Drug-Drug Interactions
125. Principles of Toxin Assessment and Screening
126. Toxidromes and Their Treatment
XIV. Pediatric Critical Care: Anesthesia Principles in the Pediatric Intensive Care Unit
127. Airway Management
128. Anesthesia Effects on Organ Systems
129. Anesthesia Principles and Operating Room Anesthesia Regimens
130. Malignant Hyperthermia
131. Neuromuscular Blocking Agents
132. Sedation and Analgesia
133. Tolerance, Dependency, and Withdrawal
134. Delirium
135. Procedural Sedation for the Pediatric Intensivist
XV. Pediatric Critical Care: Board Review Questions
136. Board Review Questions

In the highly specialized field of caring for children in the PICU, Fuhrman and Zimmerman's Pediatric Critical Care is the definitive reference for all members of the pediatric intensive care team. Drs. Jerry J. Zimmerman and Alexandre T. Rotta, along with an expert team of editors and contributors from around the world, have carefully updated the 6th Edition of this highly regarded text to bring you the most authoritative and useful information on today’s pediatric critical care-everything from basic science to clinical applications

• Jerry J. Zimmerman, MD, PhD, FCCM, Professor of Pediatrics and Anesthesiology, Faculty, Pediatric Critical Care Medicine, Seattle Children's Hospital, Harborview Medical Center, University of Washington School of Medicine,Seattle, Washington, USA .
• Alexandre T. Rotta, MD, FCCM, Linsalata Family Chair in Pediatric Critical Care and Emergency Medicine, Chief, Division of Pediatric Critical Care Medicine, UH Rainbow Babies & Children’s Hospital; Professor, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio