1. Principles of Gene Therapy in Reconstructive and Regenerative Surgery
2. Gene Therapy in Skin and Wound Healing
3. Gene Therapy in Pathologic Scars
4. Gene Therapy in Skeletal Muscle Repair and Regeneration
5. Gene Therapy in Cartilage Repair and Regeneration
6. Gene Therapy in Tendon Repair and Regeneration
7. Gene Therapy and Free Flaps for Therapeutic Reconstructive Surgery
8. Developing a Gene Therapy Clinical Trial: Tips and Tricks
9. Future Directions in Reconstructive and Regenerative Surgery
This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions.
Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided.
Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants.
Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.
• Offers a practical overview of the latest research discoveries and clinical trials in the field of gene therapy
• Written by prominent surgeons
• Also includes a chapter on how to develop gene therapy clinical trials
Dr. Giorgio Giatsidis received his medical degree from the San Raffaele Univerity (Milan, Italy) in 2009. He completed his training in plastic, reconstructive and aesthetic surgery at the Univerity of Padova (Padova, Italy) in 2015, where he also received his Ph.D. in Molecular Biology & Regenerative Medicine in 2018.Since 2013, he has been conducting research on tissue engineering and regeneration in the Division of Plastic Surgery of Brigham and Women’s Hosital and at Harvard Medical School (Boston, USA), joining the faculty of both Institutions later in 2015. He also holds collaborative appointments at the Boston Children`s Hosital (Boston, USA) and the San Raffaele Hospital (Milan, Italy).Dr. Giatsidis has several roles in scientific societies and an ad hoc reviewer for multiple scientific journals in the field. His research has been funded by federal sources (the U.S. Department of Defense) and pivate foundations. Currently, he is a national delegate for Italy in the Research Council of the European Association of Plastic Surgeons (EURAS).