GENETICS OF MALE INFERTILITY. A CASE-BASED GUIDE FOR CLINICIANS

1. The Molecular Genetics of Testis Determination
2. Molecular Regulation of Sperm Production Cascade
3. Spermatozoal Chromatin Structure: Role in Sperm Functions and Fertilization
4. Genetic Basis of Endocrine Regulation of Spermatogenesis
5. Epidemiology of Genetic Disorders in Male Infertility
6. Genetic Evaluation of Male Infertility
7. Genetic Basis of Sperm Morphologic Defects: Head Defects and Body and Tail Defects
8. Mitochondrial Function and Male Infertility
9. Sperm DNA Fragmentation and Male Infertility
10. The Sperm Epigenome and Potential Implications for the Developing Embryo
11. Klinefelter Syndrome
12. Chromosomal Translocations and Inversion in Male Infertility
13. Genetics of Vas Aplasia
14. Anomalies of the Y Chromosome
15. Infertility and Cryptorchidism
16. Kartagener and Immotile Cilia Syndrome
17. Persistent Müllerian Duct Syndrome
18. Disorders of Sex Determination
19. Endocrine Genetic Defects
20. Sperm Aneuploidy
21. Sperm DNA Fragmentation: Treatment Options and Evidence-Based Medicine
22. The Potential of CRISPR/Cas Gene Editing to Correct Male Infertility

This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic.
The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing.
Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.

Features
• A comprehensive and case-based overview of the genetic basis of male infertility, discussing molecular bases and consequences of genetic abnormalities
• Presents current clinical tools for diagnosis and management of male genetic abnormalities affecting fertility, including algorithms for patient counseling
• An essential guide for reproductive medicine specialists, andrologists, urologists and all clinicians treating infertile patients