HANDBOOK OF DEVELOPMENTAL NEUROTOXICOLOGY. 2ND EDITION

PART I. CELLULAR AND MOLECULAR MORPHOGENESIS OF THE NERVOUS SYSTEM
An Introductory Overview: Cellular and Molecular Morphogenesis of the Nervous System
Cheng Wang
1. Brain Morphogenesis and Developmental Neurotoxicology
Karl F. Jensen and Jeanene K. Olin
2. Neural Cell Adhesion Molecules in Normal and Abnormal Neural Development
Cheng Wang
3. Neurite Development and Neurotoxicity
Zhen He, Sherry Ferguson, Tucker A. Patterson and Merle G. Paule
4. Myelin: Structure, Function, Pathology and Targeted Therapeutics
Joseph Hanig and Geeta Negi
PART II. DEVELOPMENTAL NEUROBIOLOGY/TOXICOLOGY
An Introductory Overview
William Slikker Jr.
5. Neurotrophic Factors
Jimcy Platholi and Francis S. Lee
6. Serotonin Signaling as a Target for Craniofacial Embryotoxicity
Robert M. Greene and Michele M. Pisano
7. Neurotoxic and neurotrophic effects of GABAergic agents on the developing brain
Julia M. Gohlke
8. Neural stem cell biology and application to developmental neurotoxicity assessment
Fang Liu and Cheng Wang
9. Apoptosis as a Mechanism of Developmental Neurotoxicity
Pamela J. Lein, Suangsuda Supasai and Michelle Guignet
10. Periods of Susceptibility: Interspecies Comparison of Developmental Milestones during Ontogenesis of the Central Nervous System
John M. DeSesso and Amy Lavin Williams
11. Modeling the Neurovascular Unit in vitro and in silico
Katerine S. Saili, Todd J. Zurlinden and Thomas B. Knudsen
12. Zebrafish Models of Developmental Biology and Toxicology
Courtney Roper and Robert L. Tanguay
13. Using Caenorhabditis elegans to Study Neurotoxicity
Margaret M. Sedensky and Philip G. Morgan
PART III. SYNAPTOGENESIS AND NEUROTRANSMISSION
An Introductory Overview: Synaptogenesis and Neurotransmission
Cheng Wang
14. Human 3D in vitro Models for Developmental Neurotoxity
Leah Smirnova and Thomas Hartung
15. Ontogeny of Monoamine Neurotransmitters
Sumit Sarkar, Syed Z. Imam and Jennifer L. Walters
16. Developmental Toxicity within the Central Cholinergic Nervous System
David A. Jett, Michelle Guignet, Suangsuda Supasai and Pamela J. Lein
17. Ontogeny of Second Messenger Systems
Syed Z. Imam, Hector Rosas-Hernandez, Elvis Cuevas, Susan M. Lantz, Sumit Sarkar, Syed F. Ali and Merle G. Paule
18. The NMDA Receptors: Physiology and Neurotoxicology in the Developing Brain
Qiang Gu
PART IV. NUTRIENT AND CHEMICAL DISPOSITION
An Introductory Overview: Nutrient and Chemical Disposition
William Slikker Jr.
19. Physiologically Based Pharmacokinetic (PBPK) Models
Jeffrey W. Fisher, Xiaoxia Yang and Charles Timchalk
20. Blood-Brain Barrier: Physiological and Functional Considerations
Hector Rosas-Hernandez, Elvis Cuevas, Susan M. Lantz, Syed Z. Imam, Merle G. Paule and Syed F. Ali
21. Toxicological Mechanisms of Engineered Nanomaterials: Role of Material Properties in Inducing Different Biological Responses
R. L. Salisbury, R. Agans, M. E. Huddleston, A. Snyder, Alexandra Mendlein and Saber Hussain
22. Food and Nutrient Exposure Throughout the Life Span: How Does What We Eat Translate into Exposure, Deficiencies, and Toxicities?
Keli M. Hawthorne
23. The Microbiome Gut-Brain Axis
Carl E. Cerniglia
24. Drug and Chemical Contaminants in Breast Milk: Effects on Neurodevelopment of the Nursing Infant
Tom Leibson, Prateek Lala and Shinya Ito
PART V. BEHAVIORAL ASSESSMENT
An Introductory Overview: Behavioral Assessment
Merle G. Paule
25. Behavioral Phenotyping in Developmental Neurotoxicology – Simple Approaches using Unconditioned Behaviors in Rodents
Devon L. Graham, Jerrold S. Meyer and Gregg D. Stanwood
26. Psychometric Tools to Study Cognition, Sensory Functioning and Social Behavior in Infant and Adolescent Nonhuman Primates
Thomas M. Burbacher and Kimberly S. Grant
27. Automated assessment of cognitive function in nonhuman primates
John C. Talpos and Merle G. Paule
28. Determining the validity of pre-clinical behavioral assessments for extrapolation to a clinical setting
John C. Talpos and John J. Chelonis
29. Behavioral Outcome as a Primary Organizing Principle for Mechanistic Data in Developmental Neurotoxicity
Christina Sobin and Mari Golub
PART VI. CLINICAL ASSESSMENT AND EPIDEMIOLOGY
An Introductory Overview: Clinical Assessment and Epidemiology
Jan M. Friedman
30. Evaluation of the Human Newborn Infant
Lilly Bogicevic, Marjolein Verhoeven and Anneloes van Baar
31. Neuropsychological Assessment of Children in Studies of Developmental Neurotoxicity
David C. Bellinger and Johanna Calderon
32. Neurodevelopmental Assessment of the Older Infant and Child
William J. Barbaresi and Julie Bickel
33. Longitudinal Studies of the Effects of Prenatal Cocaine Exposure on Development and Behavior
Gale A. Richardson and Nancy L. Day
34. Assessment of Case Reports and Clinical Series
Jan M. Friedman
PART VII. SPECIFIC NEUROTOXIC SYNDROMES
An Introductory Overview: Specific Neurotoxic Syndromes
Merle G. Paule
35. Fetal Minamata Disease: A Human Episode of Congenital Methylmercury Poisoning
Alessandra Antunes dos Santos, Louis W. Chang, Grace Liejun Guo and Michael Aschner
36. The Developmental Neurotoxicity of Cadmium
Ashley J. Malin and Robert O. Wright
37. Developmental Neurotoxicology of Lead – Neurobehavioral and Neurological Impacts
Stephen M. Lasley
38. Fetal Alcohol Spectrum Disorder
Irena Nulman, Talya Shulman and Feiyuan Liu
39. Developmental Neurotoxicity of Nicotine and Tobacco
Edward D. Levin and Yael Abreu-Villaça
40. Developmental Neurobehavioral Neurotoxicity of Insecticides
Yael Abreu-Villaça and Edward D. Levin
41. Developmental Exposure to Polychlorinated Biphenyls Induces Deficits in Inhibitory Control and May Enhance Substance Abuse Risk
Mellessa M. Miller and Helen J K Sable
42. Developmental Neurotoxicity of General Anesthetics
Jennifer L. Walters and Merle G. Paule
43. Maternal Drug Abuse and Adverse Effects on Neurobehavior of Offspring
Diana Dow-Edwards
44. Developmental Neurotoxicology of Antiepileptic Drugs
Jocelyn M. Lutes, Jolene E. Borchelt, Patricia A. Janulewicz and Jane Adams
PART VIII. RISK ASSESSMENT
An Introductory Overview: Risk Assessment
William Slikker Jr.
45. Current Approaches to Risk Assessment for Developmental Neurotoxicity
Susan L. Makris and Andrew D. Kraft
46. Animal/Human Concordance
Larry P. Sheets and William Slikker Jr.
47. Physiologically based pharmacokinetic models in the risk assessment of developmental neurotoxicants
Kannan Krishnan
48. Application of Quantitative dose response data in risk assessment and the incorporation of high throughput data
John C. Lipscomb

• Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition
• Contains new chapters that focus on subjects recent to the field
• Includes well-illustrated material, with diagrams, charts, and tables
• Contains compelling case studies and chapters written by world experts

Authors
• William Slikker, Jr., National Center for Toxicological Research, Jefferson, US FDA, AR, USA;
• Merle G. Paule, Division of Neurotoxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, USA
• Cheng Wang, Division of Neurotoxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, USA